Comparative Antioxidant and Anti-Inflammatory Activity of Ellagic Acid and <i>Juglans regia</i> L. in Collagenase-Induced Osteoarthritis in Rats
Osteoarthritis (OA), the most common degenerative pathology of the joints, affects mainly elderly people, and it is one of the most important factors causing disability. This study aimed to assess the effect of <i>Juglans regia</i> L. on rats with collagenase-induced knee osteoarthritis...
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| author | Alina Hanga-Farcas Luminita Fritea Gabriela Adriana Filip Simona Clichici Laura Gratiela Vicas Adina Frum Mariana Eugenia Muresan |
| author_facet | Alina Hanga-Farcas Luminita Fritea Gabriela Adriana Filip Simona Clichici Laura Gratiela Vicas Adina Frum Mariana Eugenia Muresan |
| author_sort | Alina Hanga-Farcas |
| collection | DOAJ |
| description | Osteoarthritis (OA), the most common degenerative pathology of the joints, affects mainly elderly people, and it is one of the most important factors causing disability. This study aimed to assess the effect of <i>Juglans regia</i> L. on rats with collagenase-induced knee osteoarthritis comparative with groups with the same disease treated with ellagic acid (EA), indomethacin as positive control and vehicle as negative control. After 2 and 4 weeks of treatment, blood samples were collected in order to evaluate the oxidative stress and inflammation, as well as RANKL and hydroxyproline levels. The results showed that EA improved the systemic antioxidant defense (<i>p</i> < 0.05), decreased the interleukin-6 (IL-6) secretion (<i>p</i> < 0 < 0.05) and RANKL levels (<i>p</i> < 0.01 and <i>p</i> < 0.001) at the same time enhancing hydroxyproline values, particularly after 2 weeks of treatment (<i>p</i> < 0.01). JR extract especially maintained low values of RANKL (<i>p</i> < 0.05) and hydroxyproline levels (<i>p</i> < 0.05), indicating a partial chondroprotective effect compared to EA. In conclusion, the use of EA and JR extract can improve some parameters of bone regeneration in experimental osteoarthritis, suggesting beneficial effects in articular inflammatory diseases. However, further studies are necessary to establish the optimum dose and time of treatment with both compounds in order to obtain optimal therapeutic results. |
| format | Article |
| id | doaj-art-ee414b09faac4cdf8772566b18bf1a7c |
| institution | DOAJ |
| issn | 2076-3417 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | MDPI AG |
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| series | Applied Sciences |
| spelling | doaj-art-ee414b09faac4cdf8772566b18bf1a7c2025-08-20T03:11:30ZengMDPI AGApplied Sciences2076-34172025-05-011511581410.3390/app15115814Comparative Antioxidant and Anti-Inflammatory Activity of Ellagic Acid and <i>Juglans regia</i> L. in Collagenase-Induced Osteoarthritis in RatsAlina Hanga-Farcas0Luminita Fritea1Gabriela Adriana Filip2Simona Clichici3Laura Gratiela Vicas4Adina Frum5Mariana Eugenia Muresan6Doctoral School of Biomedical Sciences, University of Oradea, 1 University Street, 410087 Oradea, RomaniaDepartment of Preclinical Discipline, Faculty of Medicine and Pharmacy, University of Oradea, 10, 1 December Square, 410073 Oradea, RomaniaDepartment of Physiology, Iuliu Hatieganu University of Medicine and Pharmacy, 8 Victor Babes Street, 400347 Cluj-Napoca, RomaniaDepartment of Physiology, Iuliu Hatieganu University of Medicine and Pharmacy, 8 Victor Babes Street, 400347 Cluj-Napoca, RomaniaDepartment of Pharmacy, Faculty of Medicine and Pharmacy, University of Oradea, 10, 1 December Square, 410073 Oradea, RomaniaPreclinical Department, Faculty of Medicine, Lucian Blaga University of Sibiu, 550012 Sibiu, RomaniaDepartment of Preclinical Discipline, Faculty of Medicine and Pharmacy, University of Oradea, 10, 1 December Square, 410073 Oradea, RomaniaOsteoarthritis (OA), the most common degenerative pathology of the joints, affects mainly elderly people, and it is one of the most important factors causing disability. This study aimed to assess the effect of <i>Juglans regia</i> L. on rats with collagenase-induced knee osteoarthritis comparative with groups with the same disease treated with ellagic acid (EA), indomethacin as positive control and vehicle as negative control. After 2 and 4 weeks of treatment, blood samples were collected in order to evaluate the oxidative stress and inflammation, as well as RANKL and hydroxyproline levels. The results showed that EA improved the systemic antioxidant defense (<i>p</i> < 0.05), decreased the interleukin-6 (IL-6) secretion (<i>p</i> < 0 < 0.05) and RANKL levels (<i>p</i> < 0.01 and <i>p</i> < 0.001) at the same time enhancing hydroxyproline values, particularly after 2 weeks of treatment (<i>p</i> < 0.01). JR extract especially maintained low values of RANKL (<i>p</i> < 0.05) and hydroxyproline levels (<i>p</i> < 0.05), indicating a partial chondroprotective effect compared to EA. In conclusion, the use of EA and JR extract can improve some parameters of bone regeneration in experimental osteoarthritis, suggesting beneficial effects in articular inflammatory diseases. However, further studies are necessary to establish the optimum dose and time of treatment with both compounds in order to obtain optimal therapeutic results.https://www.mdpi.com/2076-3417/15/11/5814osteoarthritis<i>Juglans regia</i> L. extractellagic acidmalondialdehydesuperoxide dismutasecatalase |
| spellingShingle | Alina Hanga-Farcas Luminita Fritea Gabriela Adriana Filip Simona Clichici Laura Gratiela Vicas Adina Frum Mariana Eugenia Muresan Comparative Antioxidant and Anti-Inflammatory Activity of Ellagic Acid and <i>Juglans regia</i> L. in Collagenase-Induced Osteoarthritis in Rats Applied Sciences osteoarthritis <i>Juglans regia</i> L. extract ellagic acid malondialdehyde superoxide dismutase catalase |
| title | Comparative Antioxidant and Anti-Inflammatory Activity of Ellagic Acid and <i>Juglans regia</i> L. in Collagenase-Induced Osteoarthritis in Rats |
| title_full | Comparative Antioxidant and Anti-Inflammatory Activity of Ellagic Acid and <i>Juglans regia</i> L. in Collagenase-Induced Osteoarthritis in Rats |
| title_fullStr | Comparative Antioxidant and Anti-Inflammatory Activity of Ellagic Acid and <i>Juglans regia</i> L. in Collagenase-Induced Osteoarthritis in Rats |
| title_full_unstemmed | Comparative Antioxidant and Anti-Inflammatory Activity of Ellagic Acid and <i>Juglans regia</i> L. in Collagenase-Induced Osteoarthritis in Rats |
| title_short | Comparative Antioxidant and Anti-Inflammatory Activity of Ellagic Acid and <i>Juglans regia</i> L. in Collagenase-Induced Osteoarthritis in Rats |
| title_sort | comparative antioxidant and anti inflammatory activity of ellagic acid and i juglans regia i l in collagenase induced osteoarthritis in rats |
| topic | osteoarthritis <i>Juglans regia</i> L. extract ellagic acid malondialdehyde superoxide dismutase catalase |
| url | https://www.mdpi.com/2076-3417/15/11/5814 |
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