Back from the Tip of the Nose
About 130 years ago, Giulio Bizozzero, then in Pavia, made a seminal observation [1]. He divided the tissues of the vertebrate body into three categories: those that divide constantly (labile), such as blood and skin, those that never divide, such as striated muscle and brain (perennial), and those...
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| Format: | Article |
| Language: | English |
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Wiley
2001-01-01
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| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1100/tsw.2001.26 |
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| _version_ | 1849692289482358784 |
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| author | Giulio Cossu |
| author_facet | Giulio Cossu |
| author_sort | Giulio Cossu |
| collection | DOAJ |
| description | About 130 years ago, Giulio Bizozzero, then in Pavia, made a seminal observation [1]. He divided the tissues of the vertebrate body into three categories: those that divide constantly (labile), such as blood and skin, those that never divide, such as striated muscle and brain (perennial), and those that normally do not divide but can do so if injured (stable). As a consequence, diseases that perturb cell division, such as cancer, affect labile tissues, while degenerative diseases affect perennial tissues where repair is inefficient. Epithelia and blood possess a reservoir of cells that divide and maintain a progenitor pool throughout life (the stem cells) whereas striated muscle and brain were supposed not to contain stem cells. Furthermore, stem cells were supposed to generate only the cells of the tissue where they belong. |
| format | Article |
| id | doaj-art-ee3c1ef6a1514316ad2e16fc46bf9366 |
| institution | DOAJ |
| issn | 1537-744X |
| language | English |
| publishDate | 2001-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-ee3c1ef6a1514316ad2e16fc46bf93662025-08-20T03:20:44ZengWileyThe Scientific World Journal1537-744X2001-01-01122522610.1100/tsw.2001.26Back from the Tip of the NoseGiulio Cossu0Stem Cell Research Institute, H.S. Raffaele Milan and Dept. of Histology and Medical Embryology, II Medical School, University of Rome, La Sapienza, ItalyAbout 130 years ago, Giulio Bizozzero, then in Pavia, made a seminal observation [1]. He divided the tissues of the vertebrate body into three categories: those that divide constantly (labile), such as blood and skin, those that never divide, such as striated muscle and brain (perennial), and those that normally do not divide but can do so if injured (stable). As a consequence, diseases that perturb cell division, such as cancer, affect labile tissues, while degenerative diseases affect perennial tissues where repair is inefficient. Epithelia and blood possess a reservoir of cells that divide and maintain a progenitor pool throughout life (the stem cells) whereas striated muscle and brain were supposed not to contain stem cells. Furthermore, stem cells were supposed to generate only the cells of the tissue where they belong.http://dx.doi.org/10.1100/tsw.2001.26 |
| spellingShingle | Giulio Cossu Back from the Tip of the Nose The Scientific World Journal |
| title | Back from the Tip of the Nose |
| title_full | Back from the Tip of the Nose |
| title_fullStr | Back from the Tip of the Nose |
| title_full_unstemmed | Back from the Tip of the Nose |
| title_short | Back from the Tip of the Nose |
| title_sort | back from the tip of the nose |
| url | http://dx.doi.org/10.1100/tsw.2001.26 |
| work_keys_str_mv | AT giuliocossu backfromthetipofthenose |