The Effectiveness of Pre- and Postoperative Infliximab in Controlling Behçet’s Disease Posterior Uveitis in Patients Undergoing Vitrectomy: A Preliminary Study
Purpose. To evaluate the short-term effectiveness of infliximab in controlling ocular manifestations in Behçet’s Disease (BD) patients candidate for pars plana vitrectomy, if given in a regimen before and after the planned procedure. Patients and Methods. 30 eyes of 27 adult male BD patients with a...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2017-01-01
|
| Series: | Journal of Ophthalmology |
| Online Access: | http://dx.doi.org/10.1155/2017/8168369 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832568043808489472 |
|---|---|
| author | Hossam El Din Mohamed Khalil Heba A. El Gendy Hala Ahmed Raafat Hazem Effat Haroun Tamer Atef Gheita Hossam Mahmoud Bakir |
| author_facet | Hossam El Din Mohamed Khalil Heba A. El Gendy Hala Ahmed Raafat Hazem Effat Haroun Tamer Atef Gheita Hossam Mahmoud Bakir |
| author_sort | Hossam El Din Mohamed Khalil |
| collection | DOAJ |
| description | Purpose. To evaluate the short-term effectiveness of infliximab in controlling ocular manifestations in Behçet’s Disease (BD) patients candidate for pars plana vitrectomy, if given in a regimen before and after the planned procedure. Patients and Methods. 30 eyes of 27 adult male BD patients with a mean age of 35.56 yrs presented with refractory posterior uveitis not responding to immunosuppressive drugs and candidate for vitrectomy were included. Infliximab was given in a dose of 5 mg/kg intravenous infusion once every two weeks for 3 treatment sessions before the intended vitrectomy followed by 3 treatment sessions at two-week intervals, after vitrectomy. Results. Improvement of ocular manifestations was noted in all eyes, with complete resolution in 26 eyes (87%). Visual acuity improved from 0.23 ± 0.11 to 0.38 ± 0.17 (p≤0.2), ESR decreased from 65.92 mm/hr ± 17.32 SD to 24.93 mm/hr ± 5.28 SD at the last treatment cycle (p≤0.1). The mean daily dose of systemic corticosteroids was tapered from 44.54 mg/d ± 2.89 to 8.48 mg/d ± 6.38 (p≤0.2), and no relapses were noted during the follow-up period. Conclusion. Infliximab may be safe and effective in controlling posterior uveitis and inducing remissions if given in a regimen before and after vitrecomy in BD patients. |
| format | Article |
| id | doaj-art-ee376ed454404d2998ffbe0cfb3da024 |
| institution | Kabale University |
| issn | 2090-004X 2090-0058 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Ophthalmology |
| spelling | doaj-art-ee376ed454404d2998ffbe0cfb3da0242025-02-03T00:59:59ZengWileyJournal of Ophthalmology2090-004X2090-00582017-01-01201710.1155/2017/81683698168369The Effectiveness of Pre- and Postoperative Infliximab in Controlling Behçet’s Disease Posterior Uveitis in Patients Undergoing Vitrectomy: A Preliminary StudyHossam El Din Mohamed Khalil0Heba A. El Gendy1Hala Ahmed Raafat2Hazem Effat Haroun3Tamer Atef Gheita4Hossam Mahmoud Bakir5Department of Ophthalmology, Faculty of Medicine, Beni Sweif University, Beni Sweif, EgyptDepartment of Ophthalmology, Faculty of Medicine, Cairo University, Giza, EgyptDepartment of Rheumatology and Rehabilitation, Faculty of Medicine, Cairo University, Giza, EgyptDepartment of Ophthalmology, Faculty of Medicine, Beni Sweif University, Beni Sweif, EgyptDepartment of Rheumatology and Rehabilitation, Faculty of Medicine, Cairo University, Giza, EgyptDepartment of Ophthalmology, Faculty of Medicine, Beni Sweif University, Beni Sweif, EgyptPurpose. To evaluate the short-term effectiveness of infliximab in controlling ocular manifestations in Behçet’s Disease (BD) patients candidate for pars plana vitrectomy, if given in a regimen before and after the planned procedure. Patients and Methods. 30 eyes of 27 adult male BD patients with a mean age of 35.56 yrs presented with refractory posterior uveitis not responding to immunosuppressive drugs and candidate for vitrectomy were included. Infliximab was given in a dose of 5 mg/kg intravenous infusion once every two weeks for 3 treatment sessions before the intended vitrectomy followed by 3 treatment sessions at two-week intervals, after vitrectomy. Results. Improvement of ocular manifestations was noted in all eyes, with complete resolution in 26 eyes (87%). Visual acuity improved from 0.23 ± 0.11 to 0.38 ± 0.17 (p≤0.2), ESR decreased from 65.92 mm/hr ± 17.32 SD to 24.93 mm/hr ± 5.28 SD at the last treatment cycle (p≤0.1). The mean daily dose of systemic corticosteroids was tapered from 44.54 mg/d ± 2.89 to 8.48 mg/d ± 6.38 (p≤0.2), and no relapses were noted during the follow-up period. Conclusion. Infliximab may be safe and effective in controlling posterior uveitis and inducing remissions if given in a regimen before and after vitrecomy in BD patients.http://dx.doi.org/10.1155/2017/8168369 |
| spellingShingle | Hossam El Din Mohamed Khalil Heba A. El Gendy Hala Ahmed Raafat Hazem Effat Haroun Tamer Atef Gheita Hossam Mahmoud Bakir The Effectiveness of Pre- and Postoperative Infliximab in Controlling Behçet’s Disease Posterior Uveitis in Patients Undergoing Vitrectomy: A Preliminary Study Journal of Ophthalmology |
| title | The Effectiveness of Pre- and Postoperative Infliximab in Controlling Behçet’s Disease Posterior Uveitis in Patients Undergoing Vitrectomy: A Preliminary Study |
| title_full | The Effectiveness of Pre- and Postoperative Infliximab in Controlling Behçet’s Disease Posterior Uveitis in Patients Undergoing Vitrectomy: A Preliminary Study |
| title_fullStr | The Effectiveness of Pre- and Postoperative Infliximab in Controlling Behçet’s Disease Posterior Uveitis in Patients Undergoing Vitrectomy: A Preliminary Study |
| title_full_unstemmed | The Effectiveness of Pre- and Postoperative Infliximab in Controlling Behçet’s Disease Posterior Uveitis in Patients Undergoing Vitrectomy: A Preliminary Study |
| title_short | The Effectiveness of Pre- and Postoperative Infliximab in Controlling Behçet’s Disease Posterior Uveitis in Patients Undergoing Vitrectomy: A Preliminary Study |
| title_sort | effectiveness of pre and postoperative infliximab in controlling behcet s disease posterior uveitis in patients undergoing vitrectomy a preliminary study |
| url | http://dx.doi.org/10.1155/2017/8168369 |
| work_keys_str_mv | AT hossameldinmohamedkhalil theeffectivenessofpreandpostoperativeinfliximabincontrollingbehcetsdiseaseposterioruveitisinpatientsundergoingvitrectomyapreliminarystudy AT hebaaelgendy theeffectivenessofpreandpostoperativeinfliximabincontrollingbehcetsdiseaseposterioruveitisinpatientsundergoingvitrectomyapreliminarystudy AT halaahmedraafat theeffectivenessofpreandpostoperativeinfliximabincontrollingbehcetsdiseaseposterioruveitisinpatientsundergoingvitrectomyapreliminarystudy AT hazemeffatharoun theeffectivenessofpreandpostoperativeinfliximabincontrollingbehcetsdiseaseposterioruveitisinpatientsundergoingvitrectomyapreliminarystudy AT tameratefgheita theeffectivenessofpreandpostoperativeinfliximabincontrollingbehcetsdiseaseposterioruveitisinpatientsundergoingvitrectomyapreliminarystudy AT hossammahmoudbakir theeffectivenessofpreandpostoperativeinfliximabincontrollingbehcetsdiseaseposterioruveitisinpatientsundergoingvitrectomyapreliminarystudy AT hossameldinmohamedkhalil effectivenessofpreandpostoperativeinfliximabincontrollingbehcetsdiseaseposterioruveitisinpatientsundergoingvitrectomyapreliminarystudy AT hebaaelgendy effectivenessofpreandpostoperativeinfliximabincontrollingbehcetsdiseaseposterioruveitisinpatientsundergoingvitrectomyapreliminarystudy AT halaahmedraafat effectivenessofpreandpostoperativeinfliximabincontrollingbehcetsdiseaseposterioruveitisinpatientsundergoingvitrectomyapreliminarystudy AT hazemeffatharoun effectivenessofpreandpostoperativeinfliximabincontrollingbehcetsdiseaseposterioruveitisinpatientsundergoingvitrectomyapreliminarystudy AT tameratefgheita effectivenessofpreandpostoperativeinfliximabincontrollingbehcetsdiseaseposterioruveitisinpatientsundergoingvitrectomyapreliminarystudy AT hossammahmoudbakir effectivenessofpreandpostoperativeinfliximabincontrollingbehcetsdiseaseposterioruveitisinpatientsundergoingvitrectomyapreliminarystudy |