Sex differences in diagnosis and treatment of heart failure: toward precision medicine
There are sex-related differences in the pathophysiology and phenotype of heart failure (HF) as well as the pharmacokinetics and pharmacodynamics of drugs between women and men due to biological differences, such as heart and vessel size, response to blood volume and pressure, body water and muscle...
Saved in:
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
The Korean Association of Internal Medicine
2025-03-01
|
| Series: | The Korean Journal of Internal Medicine |
| Subjects: | |
| Online Access: | http://kjim.org/upload/kjim-2024-338.pdf |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849770117728043008 |
|---|---|
| author | Soo Yong Lee Seong-Mi Park |
| author_facet | Soo Yong Lee Seong-Mi Park |
| author_sort | Soo Yong Lee |
| collection | DOAJ |
| description | There are sex-related differences in the pathophysiology and phenotype of heart failure (HF) as well as the pharmacokinetics and pharmacodynamics of drugs between women and men due to biological differences, such as heart and vessel size, response to blood volume and pressure, body water and muscle compositions, and dominant sex hormones. Therefore, target drug doses required to achieve the same clinical effect differ between the sexes, while there may also be sex-related differences in side effects of a given drug at the same dose. These biological differences have been reflected in the results of clinical trials. Moreover, women have been underrepresented in pharmacological therapy trials as well as having lower device implantation rates than men. Therefore, the currently recommended target doses of medications based on clinical trials may not be appropriate for women. Although guidelines for HF have been standardized since the last major revision in 2021, most do not differentiate by sex. This review focuses on evidence regarding sex-related differences in multiple aspects of HF, including epidemiology, pathophysiology, clinical features, treatment, and prognosis, highlighting the need for sex-specific treatment guidelines. |
| format | Article |
| id | doaj-art-ee35098f1dde43b0923ca87117098fa8 |
| institution | DOAJ |
| issn | 1226-3303 2005-6648 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | The Korean Association of Internal Medicine |
| record_format | Article |
| series | The Korean Journal of Internal Medicine |
| spelling | doaj-art-ee35098f1dde43b0923ca87117098fa82025-08-20T03:03:08ZengThe Korean Association of Internal MedicineThe Korean Journal of Internal Medicine1226-33032005-66482025-03-0140219620710.3904/kjim.2024.338171003Sex differences in diagnosis and treatment of heart failure: toward precision medicineSoo Yong Lee0Seong-Mi Park1 Division of Cardiology, Department of Internal Medicine and Research Institute for Convergence of Biomedical Science and Technology, Pusan National University Yangsan Hospital, Pusan National University School of Medicine, Yangsan, Korea Division of Cardiology, Anam Hospital, Korea University College of Medicine, Seoul, KoreaThere are sex-related differences in the pathophysiology and phenotype of heart failure (HF) as well as the pharmacokinetics and pharmacodynamics of drugs between women and men due to biological differences, such as heart and vessel size, response to blood volume and pressure, body water and muscle compositions, and dominant sex hormones. Therefore, target drug doses required to achieve the same clinical effect differ between the sexes, while there may also be sex-related differences in side effects of a given drug at the same dose. These biological differences have been reflected in the results of clinical trials. Moreover, women have been underrepresented in pharmacological therapy trials as well as having lower device implantation rates than men. Therefore, the currently recommended target doses of medications based on clinical trials may not be appropriate for women. Although guidelines for HF have been standardized since the last major revision in 2021, most do not differentiate by sex. This review focuses on evidence regarding sex-related differences in multiple aspects of HF, including epidemiology, pathophysiology, clinical features, treatment, and prognosis, highlighting the need for sex-specific treatment guidelines.http://kjim.org/upload/kjim-2024-338.pdfheart failurewomensex differences |
| spellingShingle | Soo Yong Lee Seong-Mi Park Sex differences in diagnosis and treatment of heart failure: toward precision medicine The Korean Journal of Internal Medicine heart failure women sex differences |
| title | Sex differences in diagnosis and treatment of heart failure: toward precision medicine |
| title_full | Sex differences in diagnosis and treatment of heart failure: toward precision medicine |
| title_fullStr | Sex differences in diagnosis and treatment of heart failure: toward precision medicine |
| title_full_unstemmed | Sex differences in diagnosis and treatment of heart failure: toward precision medicine |
| title_short | Sex differences in diagnosis and treatment of heart failure: toward precision medicine |
| title_sort | sex differences in diagnosis and treatment of heart failure toward precision medicine |
| topic | heart failure women sex differences |
| url | http://kjim.org/upload/kjim-2024-338.pdf |
| work_keys_str_mv | AT sooyonglee sexdifferencesindiagnosisandtreatmentofheartfailuretowardprecisionmedicine AT seongmipark sexdifferencesindiagnosisandtreatmentofheartfailuretowardprecisionmedicine |