Serum uric acid level is associated with renal arteriolar hyalinosis and predicts post-donation renal function in living kidney donors.
Major guidelines for living-donor kidney transplantation underscore the need for pre-donation evaluation of renal function, hypertension, obesity, diabetes mellitus, and albuminuria to minimize the risk of donation from marginal donors. However, validity is yet to be established. We retrospectively...
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Public Library of Science (PLoS)
2025-01-01
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| Series: | PLoS ONE |
| Online Access: | https://doi.org/10.1371/journal.pone.0320482 |
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| author | Yuzuki Kano Katsuyuki Tanabe Masashi Kitagawa Hitoshi Sugiyama Tomoaki Yamanoi Kasumi Yoshinaga Kensuke Bekku Shingo Nishimura Motoo Araki Jun Wada |
| author_facet | Yuzuki Kano Katsuyuki Tanabe Masashi Kitagawa Hitoshi Sugiyama Tomoaki Yamanoi Kasumi Yoshinaga Kensuke Bekku Shingo Nishimura Motoo Araki Jun Wada |
| author_sort | Yuzuki Kano |
| collection | DOAJ |
| description | Major guidelines for living-donor kidney transplantation underscore the need for pre-donation evaluation of renal function, hypertension, obesity, diabetes mellitus, and albuminuria to minimize the risk of donation from marginal donors. However, validity is yet to be established. We retrospectively investigated the relationship between clinical characteristics and histological indices in baseline renal biopsies (0-h biopsies) and whether these parameters could predict renal function in living kidney donors one year post-donation. Seventy-six living kidney donors were recruited for this study. In histological analyses, glomerulosclerosis, arteriosclerosis, arteriolosclerosis, arteriolar hyalinosis, and interstitial fibrosis and tubular atrophy scores/indices were evaluated. Post-donation serum creatinine levels in kidney donors with arteriolar hyalinosis were significantly higher than those in individuals without arteriolar hyalinosis. There was a significant correlation between baseline serum uric acid levels and the arteriolar hyalinosis index, with baseline uric acid level identified as an independent factor for hyalinosis in multiple regression analysis. Additionally, the serum uric acid level was a significant prognostic factor for post-donation serum creatinine after adjustment for baseline clinical parameters. These data demonstrate that pre-donation serum uric acid levels are associated with arteriolar hyalinosis in the kidney and could predict a decline in renal function during the first year after donation in living kidney donors. |
| format | Article |
| id | doaj-art-ee336d46f9ff4dd9b09ba1cc9241cfe1 |
| institution | OA Journals |
| issn | 1932-6203 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj-art-ee336d46f9ff4dd9b09ba1cc9241cfe12025-08-20T01:55:23ZengPublic Library of Science (PLoS)PLoS ONE1932-62032025-01-01203e032048210.1371/journal.pone.0320482Serum uric acid level is associated with renal arteriolar hyalinosis and predicts post-donation renal function in living kidney donors.Yuzuki KanoKatsuyuki TanabeMasashi KitagawaHitoshi SugiyamaTomoaki YamanoiKasumi YoshinagaKensuke BekkuShingo NishimuraMotoo ArakiJun WadaMajor guidelines for living-donor kidney transplantation underscore the need for pre-donation evaluation of renal function, hypertension, obesity, diabetes mellitus, and albuminuria to minimize the risk of donation from marginal donors. However, validity is yet to be established. We retrospectively investigated the relationship between clinical characteristics and histological indices in baseline renal biopsies (0-h biopsies) and whether these parameters could predict renal function in living kidney donors one year post-donation. Seventy-six living kidney donors were recruited for this study. In histological analyses, glomerulosclerosis, arteriosclerosis, arteriolosclerosis, arteriolar hyalinosis, and interstitial fibrosis and tubular atrophy scores/indices were evaluated. Post-donation serum creatinine levels in kidney donors with arteriolar hyalinosis were significantly higher than those in individuals without arteriolar hyalinosis. There was a significant correlation between baseline serum uric acid levels and the arteriolar hyalinosis index, with baseline uric acid level identified as an independent factor for hyalinosis in multiple regression analysis. Additionally, the serum uric acid level was a significant prognostic factor for post-donation serum creatinine after adjustment for baseline clinical parameters. These data demonstrate that pre-donation serum uric acid levels are associated with arteriolar hyalinosis in the kidney and could predict a decline in renal function during the first year after donation in living kidney donors.https://doi.org/10.1371/journal.pone.0320482 |
| spellingShingle | Yuzuki Kano Katsuyuki Tanabe Masashi Kitagawa Hitoshi Sugiyama Tomoaki Yamanoi Kasumi Yoshinaga Kensuke Bekku Shingo Nishimura Motoo Araki Jun Wada Serum uric acid level is associated with renal arteriolar hyalinosis and predicts post-donation renal function in living kidney donors. PLoS ONE |
| title | Serum uric acid level is associated with renal arteriolar hyalinosis and predicts post-donation renal function in living kidney donors. |
| title_full | Serum uric acid level is associated with renal arteriolar hyalinosis and predicts post-donation renal function in living kidney donors. |
| title_fullStr | Serum uric acid level is associated with renal arteriolar hyalinosis and predicts post-donation renal function in living kidney donors. |
| title_full_unstemmed | Serum uric acid level is associated with renal arteriolar hyalinosis and predicts post-donation renal function in living kidney donors. |
| title_short | Serum uric acid level is associated with renal arteriolar hyalinosis and predicts post-donation renal function in living kidney donors. |
| title_sort | serum uric acid level is associated with renal arteriolar hyalinosis and predicts post donation renal function in living kidney donors |
| url | https://doi.org/10.1371/journal.pone.0320482 |
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