The enhancing role of pharmacovigilance to conventional antibiotic resistance surveillance: cross-sectional identification and analysis of reports of antibiotic resistance in VigiBase
Objectives: This study aimed to identify and analyze potential cases of antibiotic resistance in a global pharmacovigilance database. Methods: A search of VigiBase, the World Health Organization global database of adverse event reports, was done on data up to October 3, 2022 to identify suspected ca...
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Elsevier
2025-09-01
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| Series: | International Journal of Infectious Diseases |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1201971225001717 |
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| author | Joseph Mitchell Camilla Westerberg Manju Purohit Pinelopi Lundquist Cecilia Stålsby Lundborg |
| author_facet | Joseph Mitchell Camilla Westerberg Manju Purohit Pinelopi Lundquist Cecilia Stålsby Lundborg |
| author_sort | Joseph Mitchell |
| collection | DOAJ |
| description | Objectives: This study aimed to identify and analyze potential cases of antibiotic resistance in a global pharmacovigilance database. Methods: A search of VigiBase, the World Health Organization global database of adverse event reports, was done on data up to October 3, 2022 to identify suspected cases of antibiotic resistance. Reports were classified as being “probable” or “possible” to represent cases of antibiotic resistance. Results: In total, 24,312 reports of potential antibiotic resistance cases were identified during the search, with 3497 classified as probable reports and 20,815 as possible reports based on their preferred terms. For the probable reports, 91.5% were found to be “very likely” or “likely” related to antibiotic resistance, although the reporting of antimicrobial susceptibility testing (38.3% of reviewed “probable” reports and 7.2% of reviewed “possible” reports) and previous antibiotic use (12.8% of reviewed “probable” reports and 9.0% of reviewed “possible” reports) was limited. The “possible” reports identified cases of antibiotic resistance with less accuracy but highlighted important information around unexpected antibiotic failure. Conclusions: This study provides an in-depth overview of antibiotic resistance reporting in VigiBase. Certain terms identified cases with good accuracy and can contain supplementary information to conventional antibiotic resistance surveillance. These findings can guide future research; however, researchers must be aware of inherent limitations and biases. |
| format | Article |
| id | doaj-art-ee31bb3331914ea69a9db5e1c7671b46 |
| institution | DOAJ |
| issn | 1201-9712 |
| language | English |
| publishDate | 2025-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | International Journal of Infectious Diseases |
| spelling | doaj-art-ee31bb3331914ea69a9db5e1c7671b462025-08-20T03:18:38ZengElsevierInternational Journal of Infectious Diseases1201-97122025-09-0115810794710.1016/j.ijid.2025.107947The enhancing role of pharmacovigilance to conventional antibiotic resistance surveillance: cross-sectional identification and analysis of reports of antibiotic resistance in VigiBaseJoseph Mitchell0Camilla Westerberg1Manju Purohit2Pinelopi Lundquist3Cecilia Stålsby Lundborg4Department of Global Public Health, Health Systems and Policy: Improving use of medicines, Karolinska Institutet, Stockholm, Sweden; Uppsala Monitoring Centre, Uppsala, Sweden; Corresponding author: (J. Mitchell).Uppsala Monitoring Centre, Uppsala, SwedenDepartment of Global Public Health, Health Systems and Policy: Improving use of medicines, Karolinska Institutet, Stockholm, Sweden; Department of Pathology, R.D. Gardi Medical College, Ujjain, IndiaUppsala Monitoring Centre, Uppsala, SwedenDepartment of Global Public Health, Health Systems and Policy: Improving use of medicines, Karolinska Institutet, Stockholm, SwedenObjectives: This study aimed to identify and analyze potential cases of antibiotic resistance in a global pharmacovigilance database. Methods: A search of VigiBase, the World Health Organization global database of adverse event reports, was done on data up to October 3, 2022 to identify suspected cases of antibiotic resistance. Reports were classified as being “probable” or “possible” to represent cases of antibiotic resistance. Results: In total, 24,312 reports of potential antibiotic resistance cases were identified during the search, with 3497 classified as probable reports and 20,815 as possible reports based on their preferred terms. For the probable reports, 91.5% were found to be “very likely” or “likely” related to antibiotic resistance, although the reporting of antimicrobial susceptibility testing (38.3% of reviewed “probable” reports and 7.2% of reviewed “possible” reports) and previous antibiotic use (12.8% of reviewed “probable” reports and 9.0% of reviewed “possible” reports) was limited. The “possible” reports identified cases of antibiotic resistance with less accuracy but highlighted important information around unexpected antibiotic failure. Conclusions: This study provides an in-depth overview of antibiotic resistance reporting in VigiBase. Certain terms identified cases with good accuracy and can contain supplementary information to conventional antibiotic resistance surveillance. These findings can guide future research; however, researchers must be aware of inherent limitations and biases.http://www.sciencedirect.com/science/article/pii/S1201971225001717Antibiotic resistanceSurveillancePharmacovigilanceVigiBaseAntimicrobial resistance |
| spellingShingle | Joseph Mitchell Camilla Westerberg Manju Purohit Pinelopi Lundquist Cecilia Stålsby Lundborg The enhancing role of pharmacovigilance to conventional antibiotic resistance surveillance: cross-sectional identification and analysis of reports of antibiotic resistance in VigiBase International Journal of Infectious Diseases Antibiotic resistance Surveillance Pharmacovigilance VigiBase Antimicrobial resistance |
| title | The enhancing role of pharmacovigilance to conventional antibiotic resistance surveillance: cross-sectional identification and analysis of reports of antibiotic resistance in VigiBase |
| title_full | The enhancing role of pharmacovigilance to conventional antibiotic resistance surveillance: cross-sectional identification and analysis of reports of antibiotic resistance in VigiBase |
| title_fullStr | The enhancing role of pharmacovigilance to conventional antibiotic resistance surveillance: cross-sectional identification and analysis of reports of antibiotic resistance in VigiBase |
| title_full_unstemmed | The enhancing role of pharmacovigilance to conventional antibiotic resistance surveillance: cross-sectional identification and analysis of reports of antibiotic resistance in VigiBase |
| title_short | The enhancing role of pharmacovigilance to conventional antibiotic resistance surveillance: cross-sectional identification and analysis of reports of antibiotic resistance in VigiBase |
| title_sort | enhancing role of pharmacovigilance to conventional antibiotic resistance surveillance cross sectional identification and analysis of reports of antibiotic resistance in vigibase |
| topic | Antibiotic resistance Surveillance Pharmacovigilance VigiBase Antimicrobial resistance |
| url | http://www.sciencedirect.com/science/article/pii/S1201971225001717 |
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