Extramedullary myeloma is genomically complex and characterized by near-universal MAPK pathway alterations

Extramedullary myeloma is genomically complex and characterized by near-universal MAPK pathway alterations

Abstract: Extramedullary disease (EMD) is associated with an inferior prognosis and lower response rates to conventional multiple myeloma (MM)–directed therapies compared to MM without EMD. A deeper understanding of the molecular landscape and underlying drivers of EMD is essential to identify poten...

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Main Authors: Saurabh Zanwar, Joseph Novak, Wilson Gonsalves, Michael Howe, Esteban Braggio, S. Vincent Rajkumar, Moritz Binder, Dragan Jevremovic, Surendra Dasari, Shaji Kumar
Format: Article
Language:English
Published: Elsevier 2025-08-01
Series:Blood Advances
Online Access:http://www.sciencedirect.com/science/article/pii/S2473952925002897
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