Immunobiology roles of the human CD161 receptor in T cells
Human C-type lectin-like molecule CD161 is a type II transmembrane protein expressed on the surface of various lymphocytes within both the innate and adaptive immune systems. CD161 serves as a marker for innate-like T cells and IL-17-producing cells. However, the meaning of these T cells expressing...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-08-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2025.1648305/full |
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| author | Bainan Tong Mingxuan Wang Lu Liu Xinyue Yang |
| author_facet | Bainan Tong Mingxuan Wang Lu Liu Xinyue Yang |
| author_sort | Bainan Tong |
| collection | DOAJ |
| description | Human C-type lectin-like molecule CD161 is a type II transmembrane protein expressed on the surface of various lymphocytes within both the innate and adaptive immune systems. CD161 serves as a marker for innate-like T cells and IL-17-producing cells. However, the meaning of these T cells expressing CD161 has not yet been fully determined. Is CD161 merely a phenotypic marker used to identify T cells that are in a common state of activation and/or lineage? Or does this C-type lectin itself have important effector functions? This article aims to explore the latest research progress on CD161-expressing T cells, particularly human αβTCR+T and γδTCR +T cells, and evaluate the importance of CD161 expression on immune function and human diseases through this research. |
| format | Article |
| id | doaj-art-ee2bafab2e814fbba9374ab651b685ff |
| institution | Kabale University |
| issn | 1664-3224 |
| language | English |
| publishDate | 2025-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj-art-ee2bafab2e814fbba9374ab651b685ff2025-08-20T03:36:41ZengFrontiers Media S.A.Frontiers in Immunology1664-32242025-08-011610.3389/fimmu.2025.16483051648305Immunobiology roles of the human CD161 receptor in T cellsBainan TongMingxuan WangLu LiuXinyue YangHuman C-type lectin-like molecule CD161 is a type II transmembrane protein expressed on the surface of various lymphocytes within both the innate and adaptive immune systems. CD161 serves as a marker for innate-like T cells and IL-17-producing cells. However, the meaning of these T cells expressing CD161 has not yet been fully determined. Is CD161 merely a phenotypic marker used to identify T cells that are in a common state of activation and/or lineage? Or does this C-type lectin itself have important effector functions? This article aims to explore the latest research progress on CD161-expressing T cells, particularly human αβTCR+T and γδTCR +T cells, and evaluate the importance of CD161 expression on immune function and human diseases through this research.https://www.frontiersin.org/articles/10.3389/fimmu.2025.1648305/fullCD161LLT1T cellsTh17 cellsMAIT cells |
| spellingShingle | Bainan Tong Mingxuan Wang Lu Liu Xinyue Yang Immunobiology roles of the human CD161 receptor in T cells Frontiers in Immunology CD161 LLT1 T cells Th17 cells MAIT cells |
| title | Immunobiology roles of the human CD161 receptor in T cells |
| title_full | Immunobiology roles of the human CD161 receptor in T cells |
| title_fullStr | Immunobiology roles of the human CD161 receptor in T cells |
| title_full_unstemmed | Immunobiology roles of the human CD161 receptor in T cells |
| title_short | Immunobiology roles of the human CD161 receptor in T cells |
| title_sort | immunobiology roles of the human cd161 receptor in t cells |
| topic | CD161 LLT1 T cells Th17 cells MAIT cells |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2025.1648305/full |
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