Multi-omics analysis elucidates phased defense and resource allocation trade-offs in fusarium resistance of maize
Fusarium graminearum-induced ear rot may lead to severe yield losses and mycotoxin contamination, which threaten global maize production. To dissect resistance mechanisms, we integrated a genome-wide association study (GWAS) of 420 maize inbred lines across five environments with a time-resolved tra...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-09-01
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| Series: | Plant Stress |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2667064X25002453 |
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| author | Aiguo Su Senlin Xiao Zhiyong Li Sairu Duan Shuaishuai Wang Haixia Zhang Ruyang Zhang Jinfeng Xing Chunhui Li Xiaqing Wang Yanxin Zhao Shuai Wang Xuan Sun Fengge Wang Yang Yang Yuandong Wang Tianjun Xu Xueyuan Zhang Ronghuan Wang Wei Song Jiuran Zhao |
| author_facet | Aiguo Su Senlin Xiao Zhiyong Li Sairu Duan Shuaishuai Wang Haixia Zhang Ruyang Zhang Jinfeng Xing Chunhui Li Xiaqing Wang Yanxin Zhao Shuai Wang Xuan Sun Fengge Wang Yang Yang Yuandong Wang Tianjun Xu Xueyuan Zhang Ronghuan Wang Wei Song Jiuran Zhao |
| author_sort | Aiguo Su |
| collection | DOAJ |
| description | Fusarium graminearum-induced ear rot may lead to severe yield losses and mycotoxin contamination, which threaten global maize production. To dissect resistance mechanisms, we integrated a genome-wide association study (GWAS) of 420 maize inbred lines across five environments with a time-resolved transcriptomics analysis of resistant and susceptible genotypes. On the basis of GWAS, 151 significant single nucleotide polymorphisms (SNP) were identified, including novel loci in bin 7.04 and known resistance hotspots in bin 3.04. By comparing the transcriptomes of resistant (X178) and susceptible (B73) lines during early infection phases, we detected 1537 differentially expressed genes associated with pathways related to plant immune responses (e.g., defense signaling, secondary metabolism, redox homeostasis, and cytoskeletal reorganization). Additionally, 32 potential resistance genes were differentially expressed according to our transcriptome analysis, which enabled the prioritization of candidate genes, including ZmTRX (thioredoxin), ZmGuLO (ascorbate biosynthesis), and ZmVOZ1 (transcription factor). We propose that resistant maize lines have phased defense responses that transiently suppress the synthesis of storage-related proteins (e.g., α-zein), reallocate resources for immunity-related activities, and balance stress response-associated trade-offs via dynamic regulation. |
| format | Article |
| id | doaj-art-ee2aed6f6e514e5588e798d6ed3b641a |
| institution | Kabale University |
| issn | 2667-064X |
| language | English |
| publishDate | 2025-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Plant Stress |
| spelling | doaj-art-ee2aed6f6e514e5588e798d6ed3b641a2025-08-23T04:49:44ZengElsevierPlant Stress2667-064X2025-09-011710097710.1016/j.stress.2025.100977Multi-omics analysis elucidates phased defense and resource allocation trade-offs in fusarium resistance of maizeAiguo Su0Senlin Xiao1Zhiyong Li2Sairu Duan3Shuaishuai Wang4Haixia Zhang5Ruyang Zhang6Jinfeng Xing7Chunhui Li8Xiaqing Wang9Yanxin Zhao10Shuai Wang11Xuan Sun12Fengge Wang13Yang Yang14Yuandong Wang15Tianjun Xu16Xueyuan Zhang17Ronghuan Wang18Wei Song19Jiuran Zhao20Beijing Key Laboratory of Maize DNA Fingerprinting and Molecular Breeding, Beijing Academy of Agriculture and Forestry Sciences, Maize Research Institute, No. 11, Middle Shuguang Garden Road, Haidian District, Beijing, 100097, ChinaBeijing Key Laboratory of Maize DNA Fingerprinting and Molecular Breeding, Beijing Academy of Agriculture and Forestry Sciences, Maize Research Institute, No. 11, Middle Shuguang Garden Road, Haidian District, Beijing, 100097, ChinaBeijing Key Laboratory of Maize DNA Fingerprinting and Molecular Breeding, Beijing Academy of Agriculture and Forestry Sciences, Maize Research Institute, No. 11, Middle Shuguang Garden Road, Haidian District, Beijing, 100097, ChinaBeijing Key Laboratory of Maize DNA Fingerprinting and Molecular Breeding, Beijing Academy of Agriculture and Forestry Sciences, Maize Research Institute, No. 11, Middle Shuguang Garden Road, Haidian District, Beijing, 100097, ChinaBeijing Key Laboratory of Maize DNA Fingerprinting and Molecular Breeding, Beijing Academy of Agriculture and Forestry Sciences, Maize Research Institute, No. 11, Middle Shuguang Garden Road, Haidian District, Beijing, 100097, ChinaBeijing Key Laboratory of Maize DNA Fingerprinting and Molecular Breeding, Beijing Academy of Agriculture and Forestry Sciences, Maize Research Institute, No. 11, Middle Shuguang Garden Road, Haidian District, Beijing, 100097, ChinaBeijing Key Laboratory of Maize DNA Fingerprinting and Molecular Breeding, Beijing Academy of Agriculture and Forestry Sciences, Maize Research Institute, No. 11, Middle Shuguang Garden Road, Haidian District, Beijing, 100097, ChinaBeijing Key Laboratory of Maize DNA Fingerprinting and Molecular Breeding, Beijing Academy of Agriculture and Forestry Sciences, Maize Research Institute, No. 11, Middle Shuguang Garden Road, Haidian District, Beijing, 100097, ChinaBeijing Key Laboratory of Maize DNA Fingerprinting and Molecular Breeding, Beijing Academy of Agriculture and Forestry Sciences, Maize Research Institute, No. 11, Middle Shuguang Garden Road, Haidian District, Beijing, 100097, ChinaBeijing Key Laboratory of Maize DNA Fingerprinting and Molecular Breeding, Beijing Academy of Agriculture and Forestry Sciences, Maize Research Institute, No. 11, Middle Shuguang Garden Road, Haidian District, Beijing, 100097, ChinaBeijing Key Laboratory of Maize DNA Fingerprinting and Molecular Breeding, Beijing Academy of Agriculture and Forestry Sciences, Maize Research Institute, No. 11, Middle Shuguang Garden Road, Haidian District, Beijing, 100097, ChinaBeijing Key Laboratory of Maize DNA Fingerprinting and Molecular Breeding, Beijing Academy of Agriculture and Forestry Sciences, Maize Research Institute, No. 11, Middle Shuguang Garden Road, Haidian District, Beijing, 100097, ChinaBeijing Key Laboratory of Maize DNA Fingerprinting and Molecular Breeding, Beijing Academy of Agriculture and Forestry Sciences, Maize Research Institute, No. 11, Middle Shuguang Garden Road, Haidian District, Beijing, 100097, ChinaBeijing Key Laboratory of Maize DNA Fingerprinting and Molecular Breeding, Beijing Academy of Agriculture and Forestry Sciences, Maize Research Institute, No. 11, Middle Shuguang Garden Road, Haidian District, Beijing, 100097, ChinaBeijing Key Laboratory of Maize DNA Fingerprinting and Molecular Breeding, Beijing Academy of Agriculture and Forestry Sciences, Maize Research Institute, No. 11, Middle Shuguang Garden Road, Haidian District, Beijing, 100097, ChinaBeijing Key Laboratory of Maize DNA Fingerprinting and Molecular Breeding, Beijing Academy of Agriculture and Forestry Sciences, Maize Research Institute, No. 11, Middle Shuguang Garden Road, Haidian District, Beijing, 100097, ChinaBeijing Key Laboratory of Maize DNA Fingerprinting and Molecular Breeding, Beijing Academy of Agriculture and Forestry Sciences, Maize Research Institute, No. 11, Middle Shuguang Garden Road, Haidian District, Beijing, 100097, ChinaBeijing Key Laboratory of Maize DNA Fingerprinting and Molecular Breeding, Beijing Academy of Agriculture and Forestry Sciences, Maize Research Institute, No. 11, Middle Shuguang Garden Road, Haidian District, Beijing, 100097, ChinaCorresponding authors.; Beijing Key Laboratory of Maize DNA Fingerprinting and Molecular Breeding, Beijing Academy of Agriculture and Forestry Sciences, Maize Research Institute, No. 11, Middle Shuguang Garden Road, Haidian District, Beijing, 100097, ChinaCorresponding authors.; Beijing Key Laboratory of Maize DNA Fingerprinting and Molecular Breeding, Beijing Academy of Agriculture and Forestry Sciences, Maize Research Institute, No. 11, Middle Shuguang Garden Road, Haidian District, Beijing, 100097, ChinaCorresponding authors.; Beijing Key Laboratory of Maize DNA Fingerprinting and Molecular Breeding, Beijing Academy of Agriculture and Forestry Sciences, Maize Research Institute, No. 11, Middle Shuguang Garden Road, Haidian District, Beijing, 100097, ChinaFusarium graminearum-induced ear rot may lead to severe yield losses and mycotoxin contamination, which threaten global maize production. To dissect resistance mechanisms, we integrated a genome-wide association study (GWAS) of 420 maize inbred lines across five environments with a time-resolved transcriptomics analysis of resistant and susceptible genotypes. On the basis of GWAS, 151 significant single nucleotide polymorphisms (SNP) were identified, including novel loci in bin 7.04 and known resistance hotspots in bin 3.04. By comparing the transcriptomes of resistant (X178) and susceptible (B73) lines during early infection phases, we detected 1537 differentially expressed genes associated with pathways related to plant immune responses (e.g., defense signaling, secondary metabolism, redox homeostasis, and cytoskeletal reorganization). Additionally, 32 potential resistance genes were differentially expressed according to our transcriptome analysis, which enabled the prioritization of candidate genes, including ZmTRX (thioredoxin), ZmGuLO (ascorbate biosynthesis), and ZmVOZ1 (transcription factor). We propose that resistant maize lines have phased defense responses that transiently suppress the synthesis of storage-related proteins (e.g., α-zein), reallocate resources for immunity-related activities, and balance stress response-associated trade-offs via dynamic regulation.http://www.sciencedirect.com/science/article/pii/S2667064X25002453MaizeEar rotFusarium graminearumResistance genesDefense response |
| spellingShingle | Aiguo Su Senlin Xiao Zhiyong Li Sairu Duan Shuaishuai Wang Haixia Zhang Ruyang Zhang Jinfeng Xing Chunhui Li Xiaqing Wang Yanxin Zhao Shuai Wang Xuan Sun Fengge Wang Yang Yang Yuandong Wang Tianjun Xu Xueyuan Zhang Ronghuan Wang Wei Song Jiuran Zhao Multi-omics analysis elucidates phased defense and resource allocation trade-offs in fusarium resistance of maize Plant Stress Maize Ear rot Fusarium graminearum Resistance genes Defense response |
| title | Multi-omics analysis elucidates phased defense and resource allocation trade-offs in fusarium resistance of maize |
| title_full | Multi-omics analysis elucidates phased defense and resource allocation trade-offs in fusarium resistance of maize |
| title_fullStr | Multi-omics analysis elucidates phased defense and resource allocation trade-offs in fusarium resistance of maize |
| title_full_unstemmed | Multi-omics analysis elucidates phased defense and resource allocation trade-offs in fusarium resistance of maize |
| title_short | Multi-omics analysis elucidates phased defense and resource allocation trade-offs in fusarium resistance of maize |
| title_sort | multi omics analysis elucidates phased defense and resource allocation trade offs in fusarium resistance of maize |
| topic | Maize Ear rot Fusarium graminearum Resistance genes Defense response |
| url | http://www.sciencedirect.com/science/article/pii/S2667064X25002453 |
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