CYTOKINE REGULATION OF REGENERATIVE PROCESSES IN PANCREATIC GLAND IN ALLOXAN-INDUCED DIABETIC RATS, AND IT CORRECTION BY 1,3,4-THIADIAZINE COMPOSITION AND LIPOIC ACID
A comprehensive comparative evaluation of the ability of L-17 compound (2-morpholino-5- phenyl-1,3,4-thiadiazine) and antioxidant lipoic acid (LA) to correct blood cytokine levels, metabolic disorders and morphological alterations in pancreas in alloxan-induced diabetes was performed for the first t...
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| Format: | Article |
| Language: | Russian |
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St. Petersburg branch of the Russian Association of Allergologists and Clinical Immunologists
2018-01-01
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| Series: | Медицинская иммунология |
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| Online Access: | https://www.mimmun.ru/mimmun/article/view/1430 |
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| author | I. G. Danilova V. V. Emelianov I. F. Gette S. Yu. Medvedeva T. S. Bulavintseva M. V. Chereshneva L. P. Sidorova V. A. Chereshnev K. V. Sokolova |
| author_facet | I. G. Danilova V. V. Emelianov I. F. Gette S. Yu. Medvedeva T. S. Bulavintseva M. V. Chereshneva L. P. Sidorova V. A. Chereshnev K. V. Sokolova |
| author_sort | I. G. Danilova |
| collection | DOAJ |
| description | A comprehensive comparative evaluation of the ability of L-17 compound (2-morpholino-5- phenyl-1,3,4-thiadiazine) and antioxidant lipoic acid (LA) to correct blood cytokine levels, metabolic disorders and morphological alterations in pancreas in alloxan-induced diabetes was performed for the first time, using an experimental in vivo model. All the tested compounds have been found to correct hyperglycemia and decreased accumulation of glycated blood proteins. The tested L-17 compound belongs to the 1,3,4-thiadiazine series and is able to correct metabolic disorders occurring in alloxan-induced diabetes comparable to activity of LA antioxidant. However, L-17 reduces the cytokine levels to the values of intact animals, that preventing development of systemic inflammatory response which causes damage of target organs in diabetes mellitus. |
| format | Article |
| id | doaj-art-ee2997bbc10a4087862cc5ca84151671 |
| institution | Kabale University |
| issn | 1563-0625 2313-741X |
| language | Russian |
| publishDate | 2018-01-01 |
| publisher | St. Petersburg branch of the Russian Association of Allergologists and Clinical Immunologists |
| record_format | Article |
| series | Медицинская иммунология |
| spelling | doaj-art-ee2997bbc10a4087862cc5ca841516712025-08-20T04:00:09ZrusSt. Petersburg branch of the Russian Association of Allergologists and Clinical ImmunologistsМедицинская иммунология1563-06252313-741X2018-01-01201354410.15789/1563-0625-2018-1-35-44982CYTOKINE REGULATION OF REGENERATIVE PROCESSES IN PANCREATIC GLAND IN ALLOXAN-INDUCED DIABETIC RATS, AND IT CORRECTION BY 1,3,4-THIADIAZINE COMPOSITION AND LIPOIC ACIDI. G. Danilova0V. V. Emelianov1I. F. Gette2S. Yu. Medvedeva3T. S. Bulavintseva4M. V. Chereshneva5L. P. Sidorova6V. A. Chereshnev7K. V. Sokolova8B.N. Yeltsin Ural Federal University, Ekaterinburg; Institute of Immunology and Physiology, Ural Branch, Russian Academy of Sciences, EkaterinburgB.N. Yeltsin Ural Federal University, EkaterinburgB.N. Yeltsin Ural Federal University, Ekaterinburg; Institute of Immunology and Physiology, Ural Branch, Russian Academy of Sciences, EkaterinburgB.N. Yeltsin Ural Federal University, Ekaterinburg; Institute of Immunology and Physiology, Ural Branch, Russian Academy of Sciences, EkaterinburgB.N. Yeltsin Ural Federal University, Ekaterinburg; Institute of Immunology and Physiology, Ural Branch, Russian Academy of Sciences, EkaterinburgInstitute of Immunology and Physiology, Ural Branch, Russian Academy of Sciences, EkaterinburgB.N. Yeltsin Ural Federal University, EkaterinburgB.N. Yeltsin Ural Federal University, Ekaterinburg; Institute of Immunology and Physiology, Ural Branch, Russian Academy of Sciences, EkaterinburgB.N. Yeltsin Ural Federal University, EkaterinburgA comprehensive comparative evaluation of the ability of L-17 compound (2-morpholino-5- phenyl-1,3,4-thiadiazine) and antioxidant lipoic acid (LA) to correct blood cytokine levels, metabolic disorders and morphological alterations in pancreas in alloxan-induced diabetes was performed for the first time, using an experimental in vivo model. All the tested compounds have been found to correct hyperglycemia and decreased accumulation of glycated blood proteins. The tested L-17 compound belongs to the 1,3,4-thiadiazine series and is able to correct metabolic disorders occurring in alloxan-induced diabetes comparable to activity of LA antioxidant. However, L-17 reduces the cytokine levels to the values of intact animals, that preventing development of systemic inflammatory response which causes damage of target organs in diabetes mellitus.https://www.mimmun.ru/mimmun/article/view/1430diabetes mellitushyperglycemiainflammationinsulincytokineslipoic acid |
| spellingShingle | I. G. Danilova V. V. Emelianov I. F. Gette S. Yu. Medvedeva T. S. Bulavintseva M. V. Chereshneva L. P. Sidorova V. A. Chereshnev K. V. Sokolova CYTOKINE REGULATION OF REGENERATIVE PROCESSES IN PANCREATIC GLAND IN ALLOXAN-INDUCED DIABETIC RATS, AND IT CORRECTION BY 1,3,4-THIADIAZINE COMPOSITION AND LIPOIC ACID Медицинская иммунология diabetes mellitus hyperglycemia inflammation insulin cytokines lipoic acid |
| title | CYTOKINE REGULATION OF REGENERATIVE PROCESSES IN PANCREATIC GLAND IN ALLOXAN-INDUCED DIABETIC RATS, AND IT CORRECTION BY 1,3,4-THIADIAZINE COMPOSITION AND LIPOIC ACID |
| title_full | CYTOKINE REGULATION OF REGENERATIVE PROCESSES IN PANCREATIC GLAND IN ALLOXAN-INDUCED DIABETIC RATS, AND IT CORRECTION BY 1,3,4-THIADIAZINE COMPOSITION AND LIPOIC ACID |
| title_fullStr | CYTOKINE REGULATION OF REGENERATIVE PROCESSES IN PANCREATIC GLAND IN ALLOXAN-INDUCED DIABETIC RATS, AND IT CORRECTION BY 1,3,4-THIADIAZINE COMPOSITION AND LIPOIC ACID |
| title_full_unstemmed | CYTOKINE REGULATION OF REGENERATIVE PROCESSES IN PANCREATIC GLAND IN ALLOXAN-INDUCED DIABETIC RATS, AND IT CORRECTION BY 1,3,4-THIADIAZINE COMPOSITION AND LIPOIC ACID |
| title_short | CYTOKINE REGULATION OF REGENERATIVE PROCESSES IN PANCREATIC GLAND IN ALLOXAN-INDUCED DIABETIC RATS, AND IT CORRECTION BY 1,3,4-THIADIAZINE COMPOSITION AND LIPOIC ACID |
| title_sort | cytokine regulation of regenerative processes in pancreatic gland in alloxan induced diabetic rats and it correction by 1 3 4 thiadiazine composition and lipoic acid |
| topic | diabetes mellitus hyperglycemia inflammation insulin cytokines lipoic acid |
| url | https://www.mimmun.ru/mimmun/article/view/1430 |
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