Research Progress in the Screening of Antimicrobial Substances Based on Machine Learning

The problem of bacterial resistance poses a significant threat to human and animal health as well as public safety, making the discovery of effective new antimicrobial compounds an urgent priority. Traditional methods for screening antimicrobial activity are often time-consuming and labor-intensive,...

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Main Author: HOU Jiangxia, JIANG Jinhui, WANG Chenxin, WANG Lan, SHI Liu, WU Wenjin, GUO Xiaojia, CHEN Sheng, CHEN Lang, CAO Feng, SUN Li, ZHOU Zhi
Format: Article
Language:English
Published: China Food Publishing Company 2025-07-01
Series:Shipin Kexue
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Online Access:https://www.spkx.net.cn/fileup/1002-6630/PDF/2025-46-14-039.pdf
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author HOU Jiangxia, JIANG Jinhui, WANG Chenxin, WANG Lan, SHI Liu, WU Wenjin, GUO Xiaojia, CHEN Sheng, CHEN Lang, CAO Feng, SUN Li, ZHOU Zhi
author_facet HOU Jiangxia, JIANG Jinhui, WANG Chenxin, WANG Lan, SHI Liu, WU Wenjin, GUO Xiaojia, CHEN Sheng, CHEN Lang, CAO Feng, SUN Li, ZHOU Zhi
author_sort HOU Jiangxia, JIANG Jinhui, WANG Chenxin, WANG Lan, SHI Liu, WU Wenjin, GUO Xiaojia, CHEN Sheng, CHEN Lang, CAO Feng, SUN Li, ZHOU Zhi
collection DOAJ
description The problem of bacterial resistance poses a significant threat to human and animal health as well as public safety, making the discovery of effective new antimicrobial compounds an urgent priority. Traditional methods for screening antimicrobial activity are often time-consuming and labor-intensive, with limited accuracy and objectivity. As a branch of artificial intelligence, machine learning algorithms have demonstrated exceptional capabilities in processing large-scale data, feature extraction, and model optimization, leading to their increasing application in the screening of antimicrobial substances. This paper reviews commonly used machine learning models, such as random forests, support vector machines, and deep learning, in antimicrobial activity screening. It provides an in-depth exploration of machine learning applications in the discovery of antimicrobial peptides, essential oils, and polyphenols, aiming to offer valuable insights into the application of machine learning techniques for identifying antimicrobial compounds.
format Article
id doaj-art-ee268b4fff884eb8b89b4bb5ef5b3364
institution Kabale University
issn 1002-6630
language English
publishDate 2025-07-01
publisher China Food Publishing Company
record_format Article
series Shipin Kexue
spelling doaj-art-ee268b4fff884eb8b89b4bb5ef5b33642025-08-20T03:25:07ZengChina Food Publishing CompanyShipin Kexue1002-66302025-07-01461436635610.7506/spkx1002-6630-20241130-213Research Progress in the Screening of Antimicrobial Substances Based on Machine LearningHOU Jiangxia, JIANG Jinhui, WANG Chenxin, WANG Lan, SHI Liu, WU Wenjin, GUO Xiaojia, CHEN Sheng, CHEN Lang, CAO Feng, SUN Li, ZHOU Zhi0(1. College of Biology and Food Engineering, Hubei Minzu University, Enshi 445000, China; 2. Institute of Agro-product Processing and Nuclear Agricultural Technology, Wuhan 430064, China; 3. Wuhan Liangzi Lake Aquatic Products Processing Co., Ltd., Wuhan 430212, China)The problem of bacterial resistance poses a significant threat to human and animal health as well as public safety, making the discovery of effective new antimicrobial compounds an urgent priority. Traditional methods for screening antimicrobial activity are often time-consuming and labor-intensive, with limited accuracy and objectivity. As a branch of artificial intelligence, machine learning algorithms have demonstrated exceptional capabilities in processing large-scale data, feature extraction, and model optimization, leading to their increasing application in the screening of antimicrobial substances. This paper reviews commonly used machine learning models, such as random forests, support vector machines, and deep learning, in antimicrobial activity screening. It provides an in-depth exploration of machine learning applications in the discovery of antimicrobial peptides, essential oils, and polyphenols, aiming to offer valuable insights into the application of machine learning techniques for identifying antimicrobial compounds.https://www.spkx.net.cn/fileup/1002-6630/PDF/2025-46-14-039.pdfmachine learning; antimicrobial substances; screening
spellingShingle HOU Jiangxia, JIANG Jinhui, WANG Chenxin, WANG Lan, SHI Liu, WU Wenjin, GUO Xiaojia, CHEN Sheng, CHEN Lang, CAO Feng, SUN Li, ZHOU Zhi
Research Progress in the Screening of Antimicrobial Substances Based on Machine Learning
Shipin Kexue
machine learning; antimicrobial substances; screening
title Research Progress in the Screening of Antimicrobial Substances Based on Machine Learning
title_full Research Progress in the Screening of Antimicrobial Substances Based on Machine Learning
title_fullStr Research Progress in the Screening of Antimicrobial Substances Based on Machine Learning
title_full_unstemmed Research Progress in the Screening of Antimicrobial Substances Based on Machine Learning
title_short Research Progress in the Screening of Antimicrobial Substances Based on Machine Learning
title_sort research progress in the screening of antimicrobial substances based on machine learning
topic machine learning; antimicrobial substances; screening
url https://www.spkx.net.cn/fileup/1002-6630/PDF/2025-46-14-039.pdf
work_keys_str_mv AT houjiangxiajiangjinhuiwangchenxinwanglanshiliuwuwenjinguoxiaojiachenshengchenlangcaofengsunlizhouzhi researchprogressinthescreeningofantimicrobialsubstancesbasedonmachinelearning