Estrogen receptor activation remodels TEAD1 gene expression to alleviate hepatic steatosis

Estrogen receptor activation remodels TEAD1 gene expression to alleviate hepatic steatosis

Abstract Sex-based differences in obesity-related hepatic malignancies suggest the protective roles of estrogen. Using a preclinical model, we dissected estrogen receptor (ER) isoform-driven molecular responses in high-fat diet (HFD)-induced liver diseases of male and female mice treated with or wit...

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Main Authors: Christian Sommerauer, Carlos J Gallardo-Dodd, Christina Savva, Linnea Hases, Madeleine Birgersson, Rajitha Indukuri, Joanne X Shen, Pablo Carravilla, Keyi Geng, Jonas Nørskov Søndergaard, Clàudia Ferrer-Aumatell, Grégoire Mercier, Erdinc Sezgin, Marion Korach-André, Carl Petersson, Hannes Hagström, Volker M Lauschke, Amena Archer, Cecilia Williams, Claudia Kutter
Format: Article
Language:English
Published: Springer Nature 2024-03-01
Series:Molecular Systems Biology
Subjects:
MASLD
Estrogen Receptor
Multi-omics
Enhancer–Promoter Interaction
TEAD1
Online Access:https://doi.org/10.1038/s44320-024-00024-x
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