Inhibiting Pyk2/Src expression by miR-23b-3p suppressed liver cancer stem cell function and hepatic carcinoma progression

Inhibiting Pyk2/Src expression by miR-23b-3p suppressed liver cancer stem cell function and hepatic carcinoma progression

Abstract Background Liver cancer stem cells (LCSCs) are critical drivers of metastasis and chemoresistance in hepatocellular carcinoma (HCC). Proline-rich tyrosine kinase 2 (Pyk2) has been implicated in tumor progression, but its role in LCSC stemness and HCC malignancy remains unclear. This study e...

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Bibliographic Details
Main Authors: Meng Sha, Jiang Zhang, Jin-kai Liu, Xiao-ye Qu, Chuan Shen, Ying Tong, Jie Cao
Format: Article
Language:English
Published: BMC 2025-06-01
Series:Cancer Cell International
Subjects:
Hepatocellular carcinoma
Liver cancer stem cells
Proline-rich tyrosine kinase 2
miR-23b-3p
Src
Online Access:https://doi.org/10.1186/s12935-025-03841-8
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