The association between pulmonary tuberculosis recurrence and exposure to fine particulate matter and residential greenness: A population-based retrospective study
Background and objective: To assess the association of pulmonary tuberculosis (PTB) recurrence with fine particulate matter (PM2.5) and residential greenness using a population-based retrospective study design. Methods: All incident PTB patients, registered in Tuberculosis Information Management Sys...
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Elsevier
2025-06-01
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2352771425000710 |
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| author | Yuanzhi Di Ying Peng Xiaogang Hao Henan Xin Tonglei Guo Jiang Du Xuefang Cao Lingyu Shen Juanjuan Huang Yijun He Boxuan Feng Zihan Li Jianguo Liang Chunfu Fang Ping Zhu Yu Zhang Fei Wang Xiaomeng Wang Bin Chen Bingjun Xu Lei Gao |
| author_facet | Yuanzhi Di Ying Peng Xiaogang Hao Henan Xin Tonglei Guo Jiang Du Xuefang Cao Lingyu Shen Juanjuan Huang Yijun He Boxuan Feng Zihan Li Jianguo Liang Chunfu Fang Ping Zhu Yu Zhang Fei Wang Xiaomeng Wang Bin Chen Bingjun Xu Lei Gao |
| author_sort | Yuanzhi Di |
| collection | DOAJ |
| description | Background and objective: To assess the association of pulmonary tuberculosis (PTB) recurrence with fine particulate matter (PM2.5) and residential greenness using a population-based retrospective study design. Methods: All incident PTB patients, registered in Tuberculosis Information Management System (TBIMS) from 2015 to 2019 in Quzhou City, China, were included. The data on PM2.5 exposure was extracted from the China High Air Pollutants dataset and the level of greenness was estimated using the Normalized Difference Vegetation Index (NDVI) values around the patient's residence. The Cox proportional hazards models were used to quantify the risk of PTB recurrence. Results: 6732 Eligible PTB incident patients were included in the study with a mean age of 56.86 years and a median follow-up time of 750 days. Recurrence was observed in 554 patients (8.2 %). Exposure to NDVI was observed to be negatively associated with PTB recurrence (HR: 0.86, 95 % CI: 0.75–0.98 per 0.1-unit increase). The strength of the association between higher PM2.5 and the risk of PTB recurrence was greater than that of lower PM2.5 concentrations in both low and high NDVI groups (HR:6.62 and 4.35, p-interaction <0.001). Conclusions: Our findings suggest that higher PM2.5 exposure might increase the risk of PTB recurrence, while residential greenness might have a protective effect. Like other chronic respiratory diseases, prevention and control of PTB will also benefit from comprehensive environmental management. |
| format | Article |
| id | doaj-art-ee190bafbbe641d59e896c37948151be |
| institution | OA Journals |
| issn | 2352-7714 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | One Health |
| spelling | doaj-art-ee190bafbbe641d59e896c37948151be2025-08-20T02:08:00ZengElsevierOne Health2352-77142025-06-012010103510.1016/j.onehlt.2025.101035The association between pulmonary tuberculosis recurrence and exposure to fine particulate matter and residential greenness: A population-based retrospective studyYuanzhi Di0Ying Peng1Xiaogang Hao2Henan Xin3Tonglei Guo4Jiang Du5Xuefang Cao6Lingyu Shen7Juanjuan Huang8Yijun He9Boxuan Feng10Zihan Li11Jianguo Liang12Chunfu Fang13Ping Zhu14Yu Zhang15Fei Wang16Xiaomeng Wang17Bin Chen18Bingjun Xu19Lei Gao20NHC Key Laboratory of Systems Biology of Pathogens, National Institute of Pathogen Biology, and Center for Tuberculosis Research, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 102629, PR China; Key Laboratory of Pathogen Infection Prevention and Control (Ministry of Education), National Institute of Pathogen Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 102629, PR ChinaCenter for Diseases Control and Prevention of Quzhou City, 324003, PR ChinaZhejiang Provincial Center for Diseases Control and Prevention, 310009, PR ChinaNHC Key Laboratory of Systems Biology of Pathogens, National Institute of Pathogen Biology, and Center for Tuberculosis Research, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 102629, PR China; Key Laboratory of Pathogen Infection Prevention and Control (Ministry of Education), National Institute of Pathogen Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 102629, PR ChinaNHC Key Laboratory of Systems Biology of Pathogens, National Institute of Pathogen Biology, and Center for Tuberculosis Research, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 102629, PR China; Key Laboratory of Pathogen Infection Prevention and Control (Ministry of Education), National Institute of Pathogen Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 102629, PR China; Center for Diseases Control and Prevention of Quzhou City, 324003, PR China; Zhejiang Provincial Center for Diseases Control and Prevention, 310009, PR China; Department of Neonatology, Shanghai Children’s Medical Center GuiZhou Hospital, Shanghai Jiao Tong University School of Medicine, No.166, Jinzhu East Road, Guanshanhu District, Guiyang 550081, PR China; Department of Neonatology, Guizhou Provincial People’s Hospital, No.83, Zhongshan East Road, Nanming District, Guiyang 550002, PR ChinaNHC Key Laboratory of Systems Biology of Pathogens, National Institute of Pathogen Biology, and Center for Tuberculosis Research, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 102629, PR China; Key Laboratory of Pathogen Infection Prevention and Control (Ministry of Education), National Institute of Pathogen Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 102629, PR ChinaNHC Key Laboratory of Systems Biology of Pathogens, National Institute of Pathogen Biology, and Center for Tuberculosis Research, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 102629, PR China; Key Laboratory of Pathogen Infection Prevention and Control (Ministry of Education), National Institute of Pathogen Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 102629, PR ChinaNHC Key Laboratory of Systems Biology of Pathogens, National Institute of Pathogen Biology, and Center for Tuberculosis Research, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 102629, PR China; Key Laboratory of Pathogen Infection Prevention and Control (Ministry of Education), National Institute of Pathogen Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 102629, PR ChinaNHC Key Laboratory of Systems Biology of Pathogens, National Institute of Pathogen Biology, and Center for Tuberculosis Research, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 102629, PR China; Key Laboratory of Pathogen Infection Prevention and Control (Ministry of Education), National Institute of Pathogen Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 102629, PR ChinaNHC Key Laboratory of Systems Biology of Pathogens, National Institute of Pathogen Biology, and Center for Tuberculosis Research, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 102629, PR China; Key Laboratory of Pathogen Infection Prevention and Control (Ministry of Education), National Institute of Pathogen Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 102629, PR ChinaNHC Key Laboratory of Systems Biology of Pathogens, National Institute of Pathogen Biology, and Center for Tuberculosis Research, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 102629, PR China; Key Laboratory of Pathogen Infection Prevention and Control (Ministry of Education), National Institute of Pathogen Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 102629, PR ChinaNHC Key Laboratory of Systems Biology of Pathogens, National Institute of Pathogen Biology, and Center for Tuberculosis Research, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 102629, PR China; Key Laboratory of Pathogen Infection Prevention and Control (Ministry of Education), National Institute of Pathogen Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 102629, PR ChinaNHC Key Laboratory of Systems Biology of Pathogens, National Institute of Pathogen Biology, and Center for Tuberculosis Research, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 102629, PR China; Key Laboratory of Pathogen Infection Prevention and Control (Ministry of Education), National Institute of Pathogen Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 102629, PR ChinaCenter for Diseases Control and Prevention of Quzhou City, 324003, PR ChinaCenter for Diseases Control and Prevention of Quzhou City, 324003, PR ChinaZhejiang Provincial Center for Diseases Control and Prevention, 310009, PR ChinaZhejiang Provincial Center for Diseases Control and Prevention, 310009, PR ChinaZhejiang Provincial Center for Diseases Control and Prevention, 310009, PR ChinaZhejiang Provincial Center for Diseases Control and Prevention, 310009, PR China; Correspondence to: B. Chen, Zhejiang Provincial Center for Diseases Control and Prevention, 3399 Binsheng Road, Binjiang District, Hangzhou 310009, PR China.Center for Diseases Control and Prevention of Quzhou City, 324003, PR China; Correspondence to: B. Xu, Center for Diseases Control and Prevention of Quzhou City, 154 Xi 'an Road, Quzhou City 324003, PR China.NHC Key Laboratory of Systems Biology of Pathogens, National Institute of Pathogen Biology, and Center for Tuberculosis Research, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 102629, PR China; Key Laboratory of Pathogen Infection Prevention and Control (Ministry of Education), National Institute of Pathogen Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 102629, PR China; Correspondence to: L. Gao, NHC Key Laboratory of Systems Biology of Pathogens, National Institute of Pathogen Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, 16 Tianrong Street, Daxing district, Beijing 102629, PR China.Background and objective: To assess the association of pulmonary tuberculosis (PTB) recurrence with fine particulate matter (PM2.5) and residential greenness using a population-based retrospective study design. Methods: All incident PTB patients, registered in Tuberculosis Information Management System (TBIMS) from 2015 to 2019 in Quzhou City, China, were included. The data on PM2.5 exposure was extracted from the China High Air Pollutants dataset and the level of greenness was estimated using the Normalized Difference Vegetation Index (NDVI) values around the patient's residence. The Cox proportional hazards models were used to quantify the risk of PTB recurrence. Results: 6732 Eligible PTB incident patients were included in the study with a mean age of 56.86 years and a median follow-up time of 750 days. Recurrence was observed in 554 patients (8.2 %). Exposure to NDVI was observed to be negatively associated with PTB recurrence (HR: 0.86, 95 % CI: 0.75–0.98 per 0.1-unit increase). The strength of the association between higher PM2.5 and the risk of PTB recurrence was greater than that of lower PM2.5 concentrations in both low and high NDVI groups (HR:6.62 and 4.35, p-interaction <0.001). Conclusions: Our findings suggest that higher PM2.5 exposure might increase the risk of PTB recurrence, while residential greenness might have a protective effect. Like other chronic respiratory diseases, prevention and control of PTB will also benefit from comprehensive environmental management.http://www.sciencedirect.com/science/article/pii/S2352771425000710Air pollutionGreennessPM2.5RecurrenceTuberculosis |
| spellingShingle | Yuanzhi Di Ying Peng Xiaogang Hao Henan Xin Tonglei Guo Jiang Du Xuefang Cao Lingyu Shen Juanjuan Huang Yijun He Boxuan Feng Zihan Li Jianguo Liang Chunfu Fang Ping Zhu Yu Zhang Fei Wang Xiaomeng Wang Bin Chen Bingjun Xu Lei Gao The association between pulmonary tuberculosis recurrence and exposure to fine particulate matter and residential greenness: A population-based retrospective study One Health Air pollution Greenness PM2.5 Recurrence Tuberculosis |
| title | The association between pulmonary tuberculosis recurrence and exposure to fine particulate matter and residential greenness: A population-based retrospective study |
| title_full | The association between pulmonary tuberculosis recurrence and exposure to fine particulate matter and residential greenness: A population-based retrospective study |
| title_fullStr | The association between pulmonary tuberculosis recurrence and exposure to fine particulate matter and residential greenness: A population-based retrospective study |
| title_full_unstemmed | The association between pulmonary tuberculosis recurrence and exposure to fine particulate matter and residential greenness: A population-based retrospective study |
| title_short | The association between pulmonary tuberculosis recurrence and exposure to fine particulate matter and residential greenness: A population-based retrospective study |
| title_sort | association between pulmonary tuberculosis recurrence and exposure to fine particulate matter and residential greenness a population based retrospective study |
| topic | Air pollution Greenness PM2.5 Recurrence Tuberculosis |
| url | http://www.sciencedirect.com/science/article/pii/S2352771425000710 |
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