The identity of implant materials governs the antimicrobial efficacy of SET-M33
Abstract The physical and chemical properties of implanted materials play a key role in their interaction with synthetic peptides that exert antimicrobial activity. In this study, we explored the diffusion properties and efficacy of the SET-M33 antimicrobial peptide in combination with artificial su...
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| Format: | Article |
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Nature Portfolio
2025-05-01
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| Series: | Scientific Reports |
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| Online Access: | https://doi.org/10.1038/s41598-025-99808-w |
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| author | Alessia Maranesi Sajad Mohammadi Ismael Castañon Felipe Gama-Franceschi Chiara Falciani Alessandro Pini Laura Mezzanotte Wendy Unger Aldo Ferrari |
| author_facet | Alessia Maranesi Sajad Mohammadi Ismael Castañon Felipe Gama-Franceschi Chiara Falciani Alessandro Pini Laura Mezzanotte Wendy Unger Aldo Ferrari |
| author_sort | Alessia Maranesi |
| collection | DOAJ |
| description | Abstract The physical and chemical properties of implanted materials play a key role in their interaction with synthetic peptides that exert antimicrobial activity. In this study, we explored the diffusion properties and efficacy of the SET-M33 antimicrobial peptide in combination with artificial substrates, comprising cardiac implantable electronic devices (CIEDs) or porous protective envelopes. We found that porous materials, such as biosynthesized cellulose, polymeric meshes, and electrospun membranes, were conducive to SET-M33 diffusion. The diffusion dynamics was controlled by the intrinsic fibrous architecture of the materials. Biosynthesized cellulose supported the peptide’s antimicrobial activity against E. coli and S. aureus. The efficacy of SET-M33 was instead reduced when combined with the other tested porous membranes and non-porous CIED interfaces, such as titanium and silicone. On the other hand, the low porosity of biosynthesized cellulose membranes, while effective in retaining the drug, diminished diffusion and thus peptide availability. In light of these findings, the implications for the use of antimicrobial peptides in the prevention of CIED surgical pocket infections are discussed. |
| format | Article |
| id | doaj-art-ee1770c8c53a4e0cb60cb5798bbbb1e7 |
| institution | DOAJ |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj-art-ee1770c8c53a4e0cb60cb5798bbbb1e72025-08-20T03:09:35ZengNature PortfolioScientific Reports2045-23222025-05-0115111410.1038/s41598-025-99808-wThe identity of implant materials governs the antimicrobial efficacy of SET-M33Alessia Maranesi0Sajad Mohammadi1Ismael Castañon2Felipe Gama-Franceschi3Chiara Falciani4Alessandro Pini5Laura Mezzanotte6Wendy Unger7Aldo Ferrari8Department of Material Science and Engineering, Universitat Politècnica de CatalunyaDepartment of Pediatrics, Laboratory of Pediatrics, Erasmus MC - Sophia Children’s Hospital, Erasmus University Medical CentreDepartment of Medical Biotechnologies, University of SienaDepartment of Radiology & Nuclear Medicine, Erasmus MC, Erasmus University Medical CentreDepartment of Medical Biotechnologies, University of SienaDepartment of Medical Biotechnologies, University of SienaDepartment of Molecular Genetics, Erasmus MC, Erasmus University Medical CentreDepartment of Pediatrics, Laboratory of Pediatrics, Erasmus MC - Sophia Children’s Hospital, Erasmus University Medical CentreHylomorph AG, TechnoparkAbstract The physical and chemical properties of implanted materials play a key role in their interaction with synthetic peptides that exert antimicrobial activity. In this study, we explored the diffusion properties and efficacy of the SET-M33 antimicrobial peptide in combination with artificial substrates, comprising cardiac implantable electronic devices (CIEDs) or porous protective envelopes. We found that porous materials, such as biosynthesized cellulose, polymeric meshes, and electrospun membranes, were conducive to SET-M33 diffusion. The diffusion dynamics was controlled by the intrinsic fibrous architecture of the materials. Biosynthesized cellulose supported the peptide’s antimicrobial activity against E. coli and S. aureus. The efficacy of SET-M33 was instead reduced when combined with the other tested porous membranes and non-porous CIED interfaces, such as titanium and silicone. On the other hand, the low porosity of biosynthesized cellulose membranes, while effective in retaining the drug, diminished diffusion and thus peptide availability. In light of these findings, the implications for the use of antimicrobial peptides in the prevention of CIED surgical pocket infections are discussed.https://doi.org/10.1038/s41598-025-99808-wImplant materialsSurgical pocket infectionAntimicrobial peptidesResistant bacteriaProtective envelopes |
| spellingShingle | Alessia Maranesi Sajad Mohammadi Ismael Castañon Felipe Gama-Franceschi Chiara Falciani Alessandro Pini Laura Mezzanotte Wendy Unger Aldo Ferrari The identity of implant materials governs the antimicrobial efficacy of SET-M33 Scientific Reports Implant materials Surgical pocket infection Antimicrobial peptides Resistant bacteria Protective envelopes |
| title | The identity of implant materials governs the antimicrobial efficacy of SET-M33 |
| title_full | The identity of implant materials governs the antimicrobial efficacy of SET-M33 |
| title_fullStr | The identity of implant materials governs the antimicrobial efficacy of SET-M33 |
| title_full_unstemmed | The identity of implant materials governs the antimicrobial efficacy of SET-M33 |
| title_short | The identity of implant materials governs the antimicrobial efficacy of SET-M33 |
| title_sort | identity of implant materials governs the antimicrobial efficacy of set m33 |
| topic | Implant materials Surgical pocket infection Antimicrobial peptides Resistant bacteria Protective envelopes |
| url | https://doi.org/10.1038/s41598-025-99808-w |
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