Increased DNA methylation of Igf2 in the male hippocampus regulates age-related deficits in synaptic plasticity and memory

Increased DNA methylation of Igf2 in the male hippocampus regulates age-related deficits in synaptic plasticity and memory

The aging process is characterized by a general decline in cognitive abilities, which affects nearly 33 % of U.S. adults over the age of 70 and is a risk factor for the development of dementia and Alzheimer’s disease. Numerous studies have reported increased neuroinflammation and impaired synaptic p...

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Bibliographic Details
Main Authors: Shannon Kincaid, Courtney P. Stickling, Kayla Farrell, Yeeun Bae, Morgan B. Patrick, Gitali Bhanot, Adam Cummings, Jennifer Abraham, Abby Alisesky, Nicole Ferrara, J. Amiel Rosenkranz, Timothy J. Jarome
Format: Article
Language:English
Published: Elsevier 2025-10-01
Series:Brain Research Bulletin
Subjects:
Aging
Memory
Hippocampus
Igf2
DNA methylation
Online Access:http://www.sciencedirect.com/science/article/pii/S0361923025003211
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