High-salt diet decreases FOLFOX efficacy via gut bacterial tryptophan metabolism in colorectal cancer

High-salt diet decreases FOLFOX efficacy via gut bacterial tryptophan metabolism in colorectal cancer

Abstract Background FOLFOX is the recommended chemotherapy regimen for colorectal cancer (CRC), but its response rate remains low. Our previous studies have established a close relationship between gut microbiota and the anti-CRC effect of FOLFOX, though the underlying mechanisms remain unclear. Die...

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Main Authors: Yufei Deng, Xiaoying Hou, Qian Fang, Haiping Wang, Xiaoxuan Li, Zhiyong Hu, Zhaolu Liu, Limei Fan, Yunyi Liu, Zhengqi Fu, Xiji Shu, Binlian Sun, Lijun Huang, Yuchen Liu
Format: Article
Language:English
Published: BMC 2025-02-01
Series:Molecular Medicine
Subjects:
CRC
FOLFOX
High-salt diet
Tryptophan metabolism
Immune regulation
Online Access:https://doi.org/10.1186/s10020-025-01122-8
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