Avian interferon regulatory factor (IRF) family reunion: IRF3 and IRF9 found

Avian interferon regulatory factor (IRF) family reunion: IRF3 and IRF9 found

Abstract Background Interferon regulatory factors (IRFs) are a family of transcription factors with important functions in immunity. The genomes of most vertebrates encode ten IRF genes. IRF3 and IRF9 have key roles in interferon (IFN) induction and signaling. Most of our knowledge about the IFN pat...

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Main Authors: Lenka Ungrová, Josef Geryk, Marina Kohn, Dana Kučerová, Veronika Krchlíková, Tomáš Hron, Vladimír Pečenka, Petr Pajer, Eliška Gáliková, Ľubomíra Pecnová, Bernd Kaspers, Jiří Hejnar, Jiří Nehyba, Daniel Elleder
Format: Article
Language:English
Published: BMC 2025-07-01
Series:BMC Biology
Subjects:
Avian genome
Interferon signaling
Interferon regulatory factors
Gene loss
Online Access:https://doi.org/10.1186/s12915-025-02261-4
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