Antihyperlipidemic and Antiinflammatory Activity of Crude Oil Anguilla Marmorata [Q.] Gaimard in White Rats (Rattus Norvegicus)
Fish oil has omega-3 and omega-6 fatty acids, which provide health benefits such as prevention of an increase in total cholesterol, triglycerides, and a decrease in blood HDL, as well as being anti-inflammatory agents in humans. The present study was conducted to determine the antihyperlipidemic and...
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Pusat Pengembangan Teknologi Informasi Dan Jurnal Universitas Muhammadiyah Palu
2024-03-01
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| Series: | Journal of Public Health and Pharmacy |
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| Online Access: | https://jurnal.unismuhpalu.ac.id/index.php/jphp/article/view/4817 |
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| author | Jamaluddin Jamaluddin Khildah Khaerati Ihwan Ihwan Yusriadi Yusriadi Andi Ratihsekarningrum Siradje Apriyana Soputra Novita Christiana Ponganan Klerensia Defneir Titing Novianti Batti Andi Mustika Andi Alfianto Moh. Rifki Janes Krisly Finta Amalinda |
| author_facet | Jamaluddin Jamaluddin Khildah Khaerati Ihwan Ihwan Yusriadi Yusriadi Andi Ratihsekarningrum Siradje Apriyana Soputra Novita Christiana Ponganan Klerensia Defneir Titing Novianti Batti Andi Mustika Andi Alfianto Moh. Rifki Janes Krisly Finta Amalinda |
| author_sort | Jamaluddin Jamaluddin |
| collection | DOAJ |
| description | Fish oil has omega-3 and omega-6 fatty acids, which provide health benefits such as prevention of an increase in total cholesterol, triglycerides, and a decrease in blood HDL, as well as being anti-inflammatory agents in humans. The present study was conducted to determine the antihyperlipidemic and anti-inflammatory activities of eel fish (Anguilla marmorata [Q.] Gaimard) oil extracts on white rats (Rattus norvegicus). To test hyperlipidemia, 25 rats were divided into 5 groups and treated with; 1.5 % PEG 400 (negative control), 20 mg simvastatin (positive control), test doses of 18, 36, and 72 mg/kg. The treatments were carried out for 39 days. In investigating the anti-inflammatory activity, 25 white rats were divided into 5 groups; negative control, positive control, three-dose treatments of 22, 44, and 88 mg/200 g. Blood cholesterol levels were measured and percent inflammation was determined. The results showed that the eel oil extracts led to a decreased of total cholesterol levels 49.60 %, triglycerides 31.15 %, and HDL 14.3 %. The percentage of inflammation values ranged from 31.73 to 54.48 %. The findings indicated that the most effective doses for the antihyperlipidemic effect were 72 mg/ kg, while 22 mg/200 g for the anti-inflammatory activity. |
| format | Article |
| id | doaj-art-ee0dc0038c1c41d9bb7e8f1cb9451114 |
| institution | Kabale University |
| issn | 2775-4952 |
| language | English |
| publishDate | 2024-03-01 |
| publisher | Pusat Pengembangan Teknologi Informasi Dan Jurnal Universitas Muhammadiyah Palu |
| record_format | Article |
| series | Journal of Public Health and Pharmacy |
| spelling | doaj-art-ee0dc0038c1c41d9bb7e8f1cb94511142025-02-11T01:53:44ZengPusat Pengembangan Teknologi Informasi Dan Jurnal Universitas Muhammadiyah PaluJournal of Public Health and Pharmacy2775-49522024-03-0141647910.56338/jphp.v4i1.48174817Antihyperlipidemic and Antiinflammatory Activity of Crude Oil Anguilla Marmorata [Q.] Gaimard in White Rats (Rattus Norvegicus)Jamaluddin Jamaluddin0Khildah Khaerati1Ihwan Ihwan2Yusriadi Yusriadi3Andi Ratihsekarningrum Siradje4Apriyana Soputra5Novita Christiana Ponganan6Klerensia Defneir Titing7Novianti Batti8Andi Mustika9Andi Alfianto10Moh. Rifki11Janes Krisly12Finta Amalinda13Department of Pharmacy, Mathematics and Natural Science of Faculty, Tadulako University Palu, Central Sulawesi, Indonesia Department of Pharmacy, Mathematics and Natural Science of Faculty, Tadulako University Palu, Central Sulawesi, Indonesia Department of Pharmacy, Mathematics and Natural Science of Faculty, Tadulako University Palu, Central Sulawesi, Indonesia Department of Pharmacy, Mathematics and Natural Science of Faculty, Tadulako University Palu, Central Sulawesi, Indonesia Department of Pharmacy, Mathematics and Natural Science of Faculty, Tadulako University Palu, Central Sulawesi, IndonesiaDepartment of Pharmacy, Mathematics and Natural Science of Faculty, Tadulako University Palu, Central Sulawesi, IndonesiaDepartment of Pharmacy, Mathematics and Natural Science of Faculty, Tadulako University Palu, Central Sulawesi, Indonesia Department of Pharmacy, Mathematics and Natural Science of Faculty, Tadulako University Palu, Central Sulawesi, Indonesia Department of Pharmacy, Mathematics and Natural Science of Faculty, Tadulako University Palu, Central Sulawesi, Indonesia Department of Pharmacy, Mathematics and Natural Science of Faculty, Tadulako University Palu, Central Sulawesi, Indonesia Department of Pharmacy, Mathematics and Natural Science of Faculty, Tadulako University Palu, Central Sulawesi, Indonesia Department of Pharmacy, Mathematics and Natural Science of Faculty, Tadulako University Palu, Central Sulawesi, Indonesia Department of Pharmacy, Mathematics and Natural Science of Faculty, Tadulako University Palu, Central Sulawesi, Indonesia Public Health Study Program, Faculty of Public Health, Muhammadiyah University Palu, Central Sulawesi, IndonesiaFish oil has omega-3 and omega-6 fatty acids, which provide health benefits such as prevention of an increase in total cholesterol, triglycerides, and a decrease in blood HDL, as well as being anti-inflammatory agents in humans. The present study was conducted to determine the antihyperlipidemic and anti-inflammatory activities of eel fish (Anguilla marmorata [Q.] Gaimard) oil extracts on white rats (Rattus norvegicus). To test hyperlipidemia, 25 rats were divided into 5 groups and treated with; 1.5 % PEG 400 (negative control), 20 mg simvastatin (positive control), test doses of 18, 36, and 72 mg/kg. The treatments were carried out for 39 days. In investigating the anti-inflammatory activity, 25 white rats were divided into 5 groups; negative control, positive control, three-dose treatments of 22, 44, and 88 mg/200 g. Blood cholesterol levels were measured and percent inflammation was determined. The results showed that the eel oil extracts led to a decreased of total cholesterol levels 49.60 %, triglycerides 31.15 %, and HDL 14.3 %. The percentage of inflammation values ranged from 31.73 to 54.48 %. The findings indicated that the most effective doses for the antihyperlipidemic effect were 72 mg/ kg, while 22 mg/200 g for the anti-inflammatory activity.https://jurnal.unismuhpalu.ac.id/index.php/jphp/article/view/4817antihyperlipidemiaanti-inflammatorycholesteroleel fishcrude oil |
| spellingShingle | Jamaluddin Jamaluddin Khildah Khaerati Ihwan Ihwan Yusriadi Yusriadi Andi Ratihsekarningrum Siradje Apriyana Soputra Novita Christiana Ponganan Klerensia Defneir Titing Novianti Batti Andi Mustika Andi Alfianto Moh. Rifki Janes Krisly Finta Amalinda Antihyperlipidemic and Antiinflammatory Activity of Crude Oil Anguilla Marmorata [Q.] Gaimard in White Rats (Rattus Norvegicus) Journal of Public Health and Pharmacy antihyperlipidemia anti-inflammatory cholesterol eel fish crude oil |
| title | Antihyperlipidemic and Antiinflammatory Activity of Crude Oil Anguilla Marmorata [Q.] Gaimard in White Rats (Rattus Norvegicus) |
| title_full | Antihyperlipidemic and Antiinflammatory Activity of Crude Oil Anguilla Marmorata [Q.] Gaimard in White Rats (Rattus Norvegicus) |
| title_fullStr | Antihyperlipidemic and Antiinflammatory Activity of Crude Oil Anguilla Marmorata [Q.] Gaimard in White Rats (Rattus Norvegicus) |
| title_full_unstemmed | Antihyperlipidemic and Antiinflammatory Activity of Crude Oil Anguilla Marmorata [Q.] Gaimard in White Rats (Rattus Norvegicus) |
| title_short | Antihyperlipidemic and Antiinflammatory Activity of Crude Oil Anguilla Marmorata [Q.] Gaimard in White Rats (Rattus Norvegicus) |
| title_sort | antihyperlipidemic and antiinflammatory activity of crude oil anguilla marmorata q gaimard in white rats rattus norvegicus |
| topic | antihyperlipidemia anti-inflammatory cholesterol eel fish crude oil |
| url | https://jurnal.unismuhpalu.ac.id/index.php/jphp/article/view/4817 |
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