Polymeric Micelles in Targeted Breast Cancer Therapy：Recent Advances and Future Trends
Breast cancer (BC) is the foremost cause of death among women worldwide. Traditional chemotherapy often faces challenges such as drug resistance, off-target effects leading to severe side effects, and the poor solubility and bioavailability of cytotoxic agents; however, advancements in nanoformulati...
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| Format: | Article |
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Tsinghua University Press
2025-06-01
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| Series: | Nano Biomedicine and Engineering |
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| Online Access: | https://www.sciopen.com/article/10.26599/NBE.2025.9290122 |
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| author | Anshu Soni Vishakha Jaiswal |
| author_facet | Anshu Soni Vishakha Jaiswal |
| author_sort | Anshu Soni |
| collection | DOAJ |
| description | Breast cancer (BC) is the foremost cause of death among women worldwide. Traditional chemotherapy often faces challenges such as drug resistance, off-target effects leading to severe side effects, and the poor solubility and bioavailability of cytotoxic agents; however, advancements in nanoformulations offer promising solutions to these issues. Polymeric micelles (PMs) composed of amphiphilic block copolymers have gained significant attention due to their ability to encapsulate hydrophobic drugs and target specific sites through active and passive mechanisms. In this review, we discuss the unique properties of PMs compared to other formulations, outlining their advantages and disadvantages. We also explore various formulation methods and investigate stimuli-responsive PMs (pH, enzyme, redox, and temperature) for treating BC, alongside passive (via enhanced permeability and retention effect) and active targeting strategies. In preclinical and clinical settings, PMs have shown potential to improve drug delivery efficiency, target precision, and minimize systemic toxicity. Future studies should focus on improving these aspects to advance BC therapy. |
| format | Article |
| id | doaj-art-ee0a1b4bbcc548d58bf0c3bb18b9a5fb |
| institution | DOAJ |
| issn | 2097-3837 2150-5578 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Tsinghua University Press |
| record_format | Article |
| series | Nano Biomedicine and Engineering |
| spelling | doaj-art-ee0a1b4bbcc548d58bf0c3bb18b9a5fb2025-08-20T03:16:07ZengTsinghua University PressNano Biomedicine and Engineering2097-38372150-55782025-06-0117221223110.26599/NBE.2025.9290122Polymeric Micelles in Targeted Breast Cancer Therapy：Recent Advances and Future TrendsAnshu Soni0Vishakha Jaiswal1Amity Institute of Pharmacy, Amity University Uttar Pradesh, Lucknow Campus, Uttar Pradesh 226028, IndiaAmity Institute of Pharmacy, Amity University Uttar Pradesh, Lucknow Campus, Uttar Pradesh 226028, IndiaBreast cancer (BC) is the foremost cause of death among women worldwide. Traditional chemotherapy often faces challenges such as drug resistance, off-target effects leading to severe side effects, and the poor solubility and bioavailability of cytotoxic agents; however, advancements in nanoformulations offer promising solutions to these issues. Polymeric micelles (PMs) composed of amphiphilic block copolymers have gained significant attention due to their ability to encapsulate hydrophobic drugs and target specific sites through active and passive mechanisms. In this review, we discuss the unique properties of PMs compared to other formulations, outlining their advantages and disadvantages. We also explore various formulation methods and investigate stimuli-responsive PMs (pH, enzyme, redox, and temperature) for treating BC, alongside passive (via enhanced permeability and retention effect) and active targeting strategies. In preclinical and clinical settings, PMs have shown potential to improve drug delivery efficiency, target precision, and minimize systemic toxicity. Future studies should focus on improving these aspects to advance BC therapy.https://www.sciopen.com/article/10.26599/NBE.2025.9290122polymeric micellesbreast cancerblock copolymersactive targetingpassive targeting |
| spellingShingle | Anshu Soni Vishakha Jaiswal Polymeric Micelles in Targeted Breast Cancer Therapy：Recent Advances and Future Trends Nano Biomedicine and Engineering polymeric micelles breast cancer block copolymers active targeting passive targeting |
| title | Polymeric Micelles in Targeted Breast Cancer Therapy：Recent Advances and Future Trends |
| title_full | Polymeric Micelles in Targeted Breast Cancer Therapy：Recent Advances and Future Trends |
| title_fullStr | Polymeric Micelles in Targeted Breast Cancer Therapy：Recent Advances and Future Trends |
| title_full_unstemmed | Polymeric Micelles in Targeted Breast Cancer Therapy：Recent Advances and Future Trends |
| title_short | Polymeric Micelles in Targeted Breast Cancer Therapy：Recent Advances and Future Trends |
| title_sort | polymeric micelles in targeted breast cancer therapy recent advances and future trends |
| topic | polymeric micelles breast cancer block copolymers active targeting passive targeting |
| url | https://www.sciopen.com/article/10.26599/NBE.2025.9290122 |
| work_keys_str_mv | AT anshusoni polymericmicellesintargetedbreastcancertherapyrecentadvancesandfuturetrends AT vishakhajaiswal polymericmicellesintargetedbreastcancertherapyrecentadvancesandfuturetrends |