Targeting anti-virulence factor strategies of bacterial pathogens
Antibiotic-resistant bacterial pathogens pose substantial biosafety and health hazards, leading to millions of deaths each year. The evolution of bacterial virulence factors is mainly propelled by horizontal gene transfer (HGT). In addition to traditional antibiotics, antimicrobial strategies target...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-02-01
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| Series: | Biosafety and Health |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2590053625000084 |
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| author | Jiashu Li Tianyuan Jia Liang Yang |
| author_facet | Jiashu Li Tianyuan Jia Liang Yang |
| author_sort | Jiashu Li |
| collection | DOAJ |
| description | Antibiotic-resistant bacterial pathogens pose substantial biosafety and health hazards, leading to millions of deaths each year. The evolution of bacterial virulence factors is mainly propelled by horizontal gene transfer (HGT). In addition to traditional antibiotics, antimicrobial strategies targeting biofilm-related virulence factors and quorum sensing (QS)-related virulence factors can effectively restrain drug-resistant bacteria. Future anti-virulence strategies, encompassing natural drugs, antibiotic resistance inhibitors, monoclonal antibodies (mAbs), and vaccines, are in the development pipeline. Consequently, by disrupting virulence factors, these drugs can eliminate the ability of bacterial pathogens to cause disease. In conclusion, this Perspective comprehensively summarizes current anti-bacterial virulence factor strategies and prospects for future cutting-edge approaches, which may address the issues of antibacterial resistance and curtail the spread of pathogens in the future. |
| format | Article |
| id | doaj-art-ee09bd6738b34fb686bce0fee1263981 |
| institution | OA Journals |
| issn | 2590-0536 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Biosafety and Health |
| spelling | doaj-art-ee09bd6738b34fb686bce0fee12639812025-08-20T02:00:32ZengElsevierBiosafety and Health2590-05362025-02-01711410.1016/j.bsheal.2025.01.006Targeting anti-virulence factor strategies of bacterial pathogensJiashu Li0Tianyuan Jia1Liang Yang2Department of Pharmacology, Joint Laboratory of Guangdong-Hong Kong Universities for Vascular Homeostasis and Diseases, School of Medicine, Southern University of Science and Technology, Shenzhen 518000, China; Shenzhen National Clinical Research Center for Infectious Disease, Shenzhen Third People’s Hospital, The Second Affiliated Hospital of Southern University of Science and Technology, Shenzhen 518112, ChinaDepartment of Pharmacology, Joint Laboratory of Guangdong-Hong Kong Universities for Vascular Homeostasis and Diseases, School of Medicine, Southern University of Science and Technology, Shenzhen 518000, China; Shenzhen National Clinical Research Center for Infectious Disease, Shenzhen Third People’s Hospital, The Second Affiliated Hospital of Southern University of Science and Technology, Shenzhen 518112, China; Corresponding authors: Shenzhen National Clinical Research Center for Infectious Disease, Shenzhen Third People’s Hospital, The Second Affiliated Hospital of Southern University of Science and Technology, Shenzhen 518112, China (T. Jia and Y. Liang).Department of Pharmacology, Joint Laboratory of Guangdong-Hong Kong Universities for Vascular Homeostasis and Diseases, School of Medicine, Southern University of Science and Technology, Shenzhen 518000, China; Shenzhen National Clinical Research Center for Infectious Disease, Shenzhen Third People’s Hospital, The Second Affiliated Hospital of Southern University of Science and Technology, Shenzhen 518112, China; Corresponding authors: Shenzhen National Clinical Research Center for Infectious Disease, Shenzhen Third People’s Hospital, The Second Affiliated Hospital of Southern University of Science and Technology, Shenzhen 518112, China (T. Jia and Y. Liang).Antibiotic-resistant bacterial pathogens pose substantial biosafety and health hazards, leading to millions of deaths each year. The evolution of bacterial virulence factors is mainly propelled by horizontal gene transfer (HGT). In addition to traditional antibiotics, antimicrobial strategies targeting biofilm-related virulence factors and quorum sensing (QS)-related virulence factors can effectively restrain drug-resistant bacteria. Future anti-virulence strategies, encompassing natural drugs, antibiotic resistance inhibitors, monoclonal antibodies (mAbs), and vaccines, are in the development pipeline. Consequently, by disrupting virulence factors, these drugs can eliminate the ability of bacterial pathogens to cause disease. In conclusion, this Perspective comprehensively summarizes current anti-bacterial virulence factor strategies and prospects for future cutting-edge approaches, which may address the issues of antibacterial resistance and curtail the spread of pathogens in the future.http://www.sciencedirect.com/science/article/pii/S2590053625000084Irulence factorsHorizontal gene transferAnti-biofilm strategiesQuorum-sensing (QS) |
| spellingShingle | Jiashu Li Tianyuan Jia Liang Yang Targeting anti-virulence factor strategies of bacterial pathogens Biosafety and Health Irulence factors Horizontal gene transfer Anti-biofilm strategies Quorum-sensing (QS) |
| title | Targeting anti-virulence factor strategies of bacterial pathogens |
| title_full | Targeting anti-virulence factor strategies of bacterial pathogens |
| title_fullStr | Targeting anti-virulence factor strategies of bacterial pathogens |
| title_full_unstemmed | Targeting anti-virulence factor strategies of bacterial pathogens |
| title_short | Targeting anti-virulence factor strategies of bacterial pathogens |
| title_sort | targeting anti virulence factor strategies of bacterial pathogens |
| topic | Irulence factors Horizontal gene transfer Anti-biofilm strategies Quorum-sensing (QS) |
| url | http://www.sciencedirect.com/science/article/pii/S2590053625000084 |
| work_keys_str_mv | AT jiashuli targetingantivirulencefactorstrategiesofbacterialpathogens AT tianyuanjia targetingantivirulencefactorstrategiesofbacterialpathogens AT liangyang targetingantivirulencefactorstrategiesofbacterialpathogens |