Perspectives on Berberine and the Regulation of Gut Microbiota: As an Anti-Inflammatory Agent
Berberine is a promising agent for modulating the intestinal microbiota, playing a crucial role in human health homeostasis. This natural compound promotes the growth of beneficial bacteria such as <i>Bacteroides</i>, <i>Bifidobacterium</i>, and <i>Lactobacillus</i&g...
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MDPI AG
2025-01-01
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| author | Quintero Vargas Jael Teresa de Jesús Juan-Carlos Gálvez-Ruíz Adriana Alejandra Márquez Ibarra Mario-Alberto Leyva-Peralta |
| author_facet | Quintero Vargas Jael Teresa de Jesús Juan-Carlos Gálvez-Ruíz Adriana Alejandra Márquez Ibarra Mario-Alberto Leyva-Peralta |
| author_sort | Quintero Vargas Jael Teresa de Jesús |
| collection | DOAJ |
| description | Berberine is a promising agent for modulating the intestinal microbiota, playing a crucial role in human health homeostasis. This natural compound promotes the growth of beneficial bacteria such as <i>Bacteroides</i>, <i>Bifidobacterium</i>, and <i>Lactobacillus</i> while reducing harmful bacteria such as <i>Escherichia coli</i>. Clinical and preclinical studies demonstrate that Berberine helps regulate T2D and metabolic disorders, improves blood glucose levels during T2D, and reduces lipid profile and chronic inflammation, especially when combined with probiotics. Berberine represents a promising adjuvant therapy for inflammatory diseases, particularly intestinal disorders, due to its multifaceted actions of inhibiting proinflammatory cytokines and pathways during IBS, IBD, and UC and its modulation of gut microbiota and/or enhancement of the integrity of the intestinal epithelial barrier. This review establishes the basis for future treatment protocols with berberine and fully elucidates its mechanisms. |
| format | Article |
| id | doaj-art-edf5e3c939d643fcbbc41b5bc2a87deb |
| institution | OA Journals |
| issn | 1424-8247 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceuticals |
| spelling | doaj-art-edf5e3c939d643fcbbc41b5bc2a87deb2025-08-20T02:03:28ZengMDPI AGPharmaceuticals1424-82472025-01-0118219310.3390/ph18020193Perspectives on Berberine and the Regulation of Gut Microbiota: As an Anti-Inflammatory AgentQuintero Vargas Jael Teresa de Jesús0Juan-Carlos Gálvez-Ruíz1Adriana Alejandra Márquez Ibarra2Mario-Alberto Leyva-Peralta3Department of Health Sciences, University of Sonora, Cd. Obregón 85010, MexicoDepartment of Chemical and Biological Sciences, University of Sonora, Hermosillo 83000, MexicoDepartment of Health Sciences, University of Sonora, Cd. Obregón 85010, MexicoDepartment of Chemical-Biological and Agricultural Sciences, Universidad de Sonora, Unidad Regional Norte, Caborca 83621, MexicoBerberine is a promising agent for modulating the intestinal microbiota, playing a crucial role in human health homeostasis. This natural compound promotes the growth of beneficial bacteria such as <i>Bacteroides</i>, <i>Bifidobacterium</i>, and <i>Lactobacillus</i> while reducing harmful bacteria such as <i>Escherichia coli</i>. Clinical and preclinical studies demonstrate that Berberine helps regulate T2D and metabolic disorders, improves blood glucose levels during T2D, and reduces lipid profile and chronic inflammation, especially when combined with probiotics. Berberine represents a promising adjuvant therapy for inflammatory diseases, particularly intestinal disorders, due to its multifaceted actions of inhibiting proinflammatory cytokines and pathways during IBS, IBD, and UC and its modulation of gut microbiota and/or enhancement of the integrity of the intestinal epithelial barrier. This review establishes the basis for future treatment protocols with berberine and fully elucidates its mechanisms.https://www.mdpi.com/1424-8247/18/2/193berberinegutdysbiosis |
| spellingShingle | Quintero Vargas Jael Teresa de Jesús Juan-Carlos Gálvez-Ruíz Adriana Alejandra Márquez Ibarra Mario-Alberto Leyva-Peralta Perspectives on Berberine and the Regulation of Gut Microbiota: As an Anti-Inflammatory Agent Pharmaceuticals berberine gut dysbiosis |
| title | Perspectives on Berberine and the Regulation of Gut Microbiota: As an Anti-Inflammatory Agent |
| title_full | Perspectives on Berberine and the Regulation of Gut Microbiota: As an Anti-Inflammatory Agent |
| title_fullStr | Perspectives on Berberine and the Regulation of Gut Microbiota: As an Anti-Inflammatory Agent |
| title_full_unstemmed | Perspectives on Berberine and the Regulation of Gut Microbiota: As an Anti-Inflammatory Agent |
| title_short | Perspectives on Berberine and the Regulation of Gut Microbiota: As an Anti-Inflammatory Agent |
| title_sort | perspectives on berberine and the regulation of gut microbiota as an anti inflammatory agent |
| topic | berberine gut dysbiosis |
| url | https://www.mdpi.com/1424-8247/18/2/193 |
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