Anti-cyclic citrullinated peptide antibodies are not frequently observed in children with type 1 diabetes mellitus: a single-center study
Type 1 diabetes mellitus (DM) and rheumatoid arthritis (RA) have been reported to occur concurrently in some cases. This study aimed to evaluate the presence of anti-cyclic citrullinated peptide (CCP) antibodies, which have been reported to have diagnostic value for RA, in children with type...
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| Format: | Article |
| Language: | English |
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Hacettepe University Institute of Child Health
2016-08-01
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| Series: | The Turkish Journal of Pediatrics |
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| Online Access: | https://turkjpediatr.org/article/view/1131 |
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| author | Melek Yıldız Figen İşleten Korcan Demir Nilüfer Çelik Hüseyin Anıl Korkmaz Birsen Tuğlu Özlem Nalbantoğlu Behzat Özkan |
| author_facet | Melek Yıldız Figen İşleten Korcan Demir Nilüfer Çelik Hüseyin Anıl Korkmaz Birsen Tuğlu Özlem Nalbantoğlu Behzat Özkan |
| author_sort | Melek Yıldız |
| collection | DOAJ |
| description |
Type 1 diabetes mellitus (DM) and rheumatoid arthritis (RA) have been reported to occur concurrently in some cases. This study aimed to evaluate the presence of anti-cyclic citrullinated peptide (CCP) antibodies, which have been reported to have diagnostic value for RA, in children with type 1 DM. The study included 90 children with type 1 DM (Group 1) and 76 control cases (Group 2). The rates of reported family histories of RA and rheumatoid factor positivity did not differ between groups. In group 1, one case (1.1%) was positive for anti-CCP antibodies, whereas none of the controls were positive. The anti-CCP positive patient had no relevant joint complaints. Anti-CCP antibodies were rarely found in cases of pediatric type 1 DM. Thus, relevant screening in the follow-up of pediatric patients does not appear to be rational in the absence of any signs or symptoms of arthritis. The single case exhibiting a high anti-CCP level needs to be followed up for RA, although this positive result might be nonspecific and transient.
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| format | Article |
| id | doaj-art-edee55d12cc44515bf08b86e40bc540d |
| institution | DOAJ |
| issn | 0041-4301 2791-6421 |
| language | English |
| publishDate | 2016-08-01 |
| publisher | Hacettepe University Institute of Child Health |
| record_format | Article |
| series | The Turkish Journal of Pediatrics |
| spelling | doaj-art-edee55d12cc44515bf08b86e40bc540d2025-08-20T03:00:53ZengHacettepe University Institute of Child HealthThe Turkish Journal of Pediatrics0041-43012791-64212016-08-0158410.24953/turkjped.2016.04.008Anti-cyclic citrullinated peptide antibodies are not frequently observed in children with type 1 diabetes mellitus: a single-center studyMelek Yıldız0Figen İşleten1Korcan Demir2Nilüfer Çelik3Hüseyin Anıl Korkmaz4Birsen Tuğlu5Özlem Nalbantoğlu6Behzat Özkan7Divisions of Pediatric Endocrinology, Dr. Behçet Uz Children's Hospital, Izmir, Turkey.Divisions of Biochemistry, Dr. Behçet Uz Children's Hospital, Izmir, Turkey.Divisions of Pediatric Endocrinology, Dr. Behçet Uz Children's Hospital, Izmir, Turkey.Divisions of Biochemistry, Dr. Behçet Uz Children's Hospital, Izmir, Turkey.Divisions of Pediatric Endocrinology, Dr. Behçet Uz Children's Hospital, Izmir, Turkey.Divisions of Biochemistry, Dr. Behçet Uz Children's Hospital, Izmir, Turkey.Divisions of Pediatric Endocrinology, Dr. Behçet Uz Children's Hospital, Izmir, Turkey.Divisions of Pediatric Endocrinology, Dr. Behçet Uz Children's Hospital, Izmir, Turkey. Type 1 diabetes mellitus (DM) and rheumatoid arthritis (RA) have been reported to occur concurrently in some cases. This study aimed to evaluate the presence of anti-cyclic citrullinated peptide (CCP) antibodies, which have been reported to have diagnostic value for RA, in children with type 1 DM. The study included 90 children with type 1 DM (Group 1) and 76 control cases (Group 2). The rates of reported family histories of RA and rheumatoid factor positivity did not differ between groups. In group 1, one case (1.1%) was positive for anti-CCP antibodies, whereas none of the controls were positive. The anti-CCP positive patient had no relevant joint complaints. Anti-CCP antibodies were rarely found in cases of pediatric type 1 DM. Thus, relevant screening in the follow-up of pediatric patients does not appear to be rational in the absence of any signs or symptoms of arthritis. The single case exhibiting a high anti-CCP level needs to be followed up for RA, although this positive result might be nonspecific and transient. https://turkjpediatr.org/article/view/1131anti-cyclic citrullinated peptide antibodiesrheumatoid arthritistype 1 diabetes mellitus |
| spellingShingle | Melek Yıldız Figen İşleten Korcan Demir Nilüfer Çelik Hüseyin Anıl Korkmaz Birsen Tuğlu Özlem Nalbantoğlu Behzat Özkan Anti-cyclic citrullinated peptide antibodies are not frequently observed in children with type 1 diabetes mellitus: a single-center study The Turkish Journal of Pediatrics anti-cyclic citrullinated peptide antibodies rheumatoid arthritis type 1 diabetes mellitus |
| title | Anti-cyclic citrullinated peptide antibodies are not frequently observed in children with type 1 diabetes mellitus: a single-center study |
| title_full | Anti-cyclic citrullinated peptide antibodies are not frequently observed in children with type 1 diabetes mellitus: a single-center study |
| title_fullStr | Anti-cyclic citrullinated peptide antibodies are not frequently observed in children with type 1 diabetes mellitus: a single-center study |
| title_full_unstemmed | Anti-cyclic citrullinated peptide antibodies are not frequently observed in children with type 1 diabetes mellitus: a single-center study |
| title_short | Anti-cyclic citrullinated peptide antibodies are not frequently observed in children with type 1 diabetes mellitus: a single-center study |
| title_sort | anti cyclic citrullinated peptide antibodies are not frequently observed in children with type 1 diabetes mellitus a single center study |
| topic | anti-cyclic citrullinated peptide antibodies rheumatoid arthritis type 1 diabetes mellitus |
| url | https://turkjpediatr.org/article/view/1131 |
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