Diagnostic accuracy of MRI-based radiomic features for EGFR mutation status in non-small cell lung cancer patients with brain metastases: a meta-analysis
ObjectiveThis meta-analysis aims to evaluate the diagnostic accuracy of magnetic resonance imaging (MRI) based radiomic features for predicting epidermal growth factor receptor (EGFR) mutation status in non-small cell lung cancer (NSCLC) patients with brain metastases.MethodsWe systematically search...
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2024.1428929/full |
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| author | Yuqin Long Rong Zhao Xianfeng Du |
| author_facet | Yuqin Long Rong Zhao Xianfeng Du |
| author_sort | Yuqin Long |
| collection | DOAJ |
| description | ObjectiveThis meta-analysis aims to evaluate the diagnostic accuracy of magnetic resonance imaging (MRI) based radiomic features for predicting epidermal growth factor receptor (EGFR) mutation status in non-small cell lung cancer (NSCLC) patients with brain metastases.MethodsWe systematically searched PubMed, Embase, Cochrane Library, Web of Science, Scopus, Wanfang, and China National Knowledge Infrastructure (CNKI) for studies published up to April 30, 2024. We included those studies that utilized MRI-based radiomic features to detect EGFR mutations in NSCLC patients with brain metastases. Sensitivity, specificity, positive and negative likelihood ratios (PLR, NLR), and area under the curve (AUC) were calculated to evaluate the accuracy. Quality assessment was performed using the quality assessment of prognostic accuracy studies 2 (QUADAS-2) tool. Meta-analysis was conducted using random-effects models.ResultsA total of 13 studies involving 2,348 patients were included. The pooled sensitivity and specificity of MRI-based radiomic features for detecting EGFR mutations were 0.86 (95% CI: 0.74-0.93) and 0.83 (95% CI: 0.72-0.91), respectively. The PLR and NLR were calculated as 5.14 (3.09, 8.55) and 0.17 (0.10, 0.31), respectively. Substantial heterogeneity was observed, with I² values exceeding 50% for all parameters. The AUC for the receiver operating characteristic analysis was 0.91 (95% CI: 0.88-0.93). Subgroup analysis indicated that deep learning models and studies conducted in Asian showed higher diagnostic accuracy compared to their respective counterparts.ConclusionsMRI-based radiomic features demonstrate a high potential for accurately detecting EGFR mutations in NSCLC patients with brain metastases, particularly when advanced deep learning techniques were employed. However, the variability in diagnostic performance across different studies underscores the need for standardized radiomic protocols to enhance reproducibility and clinical utility.Systematic review registrationhttps://www.crd.york.ac.uk/prospero/, identifier CRD42024544131. |
| format | Article |
| id | doaj-art-ededc7d2bade43a382fcf76feffe0966 |
| institution | DOAJ |
| issn | 2234-943X |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj-art-ededc7d2bade43a382fcf76feffe09662025-08-20T02:43:33ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2025-01-011410.3389/fonc.2024.14289291428929Diagnostic accuracy of MRI-based radiomic features for EGFR mutation status in non-small cell lung cancer patients with brain metastases: a meta-analysisYuqin Long0Rong Zhao1Xianfeng Du2Department of Respiratory and Critical Care Medicine, The Affiliated Dazu’s Hospital of Chongqing Medical University, Chongqing, ChinaDepartment of Radiology, The Affiliated Dazu’s Hospital of Chongqing Medical University, Chongqing, ChinaDepartment of Oncology, The Affiliated Dazu’s Hospital of Chongqing Medical University, Chongqing, ChinaObjectiveThis meta-analysis aims to evaluate the diagnostic accuracy of magnetic resonance imaging (MRI) based radiomic features for predicting epidermal growth factor receptor (EGFR) mutation status in non-small cell lung cancer (NSCLC) patients with brain metastases.MethodsWe systematically searched PubMed, Embase, Cochrane Library, Web of Science, Scopus, Wanfang, and China National Knowledge Infrastructure (CNKI) for studies published up to April 30, 2024. We included those studies that utilized MRI-based radiomic features to detect EGFR mutations in NSCLC patients with brain metastases. Sensitivity, specificity, positive and negative likelihood ratios (PLR, NLR), and area under the curve (AUC) were calculated to evaluate the accuracy. Quality assessment was performed using the quality assessment of prognostic accuracy studies 2 (QUADAS-2) tool. Meta-analysis was conducted using random-effects models.ResultsA total of 13 studies involving 2,348 patients were included. The pooled sensitivity and specificity of MRI-based radiomic features for detecting EGFR mutations were 0.86 (95% CI: 0.74-0.93) and 0.83 (95% CI: 0.72-0.91), respectively. The PLR and NLR were calculated as 5.14 (3.09, 8.55) and 0.17 (0.10, 0.31), respectively. Substantial heterogeneity was observed, with I² values exceeding 50% for all parameters. The AUC for the receiver operating characteristic analysis was 0.91 (95% CI: 0.88-0.93). Subgroup analysis indicated that deep learning models and studies conducted in Asian showed higher diagnostic accuracy compared to their respective counterparts.ConclusionsMRI-based radiomic features demonstrate a high potential for accurately detecting EGFR mutations in NSCLC patients with brain metastases, particularly when advanced deep learning techniques were employed. However, the variability in diagnostic performance across different studies underscores the need for standardized radiomic protocols to enhance reproducibility and clinical utility.Systematic review registrationhttps://www.crd.york.ac.uk/prospero/, identifier CRD42024544131.https://www.frontiersin.org/articles/10.3389/fonc.2024.1428929/fullMRIradiomicsnon-small cell lung cancerbrain metastasesEGFR mutations |
| spellingShingle | Yuqin Long Rong Zhao Xianfeng Du Diagnostic accuracy of MRI-based radiomic features for EGFR mutation status in non-small cell lung cancer patients with brain metastases: a meta-analysis Frontiers in Oncology MRI radiomics non-small cell lung cancer brain metastases EGFR mutations |
| title | Diagnostic accuracy of MRI-based radiomic features for EGFR mutation status in non-small cell lung cancer patients with brain metastases: a meta-analysis |
| title_full | Diagnostic accuracy of MRI-based radiomic features for EGFR mutation status in non-small cell lung cancer patients with brain metastases: a meta-analysis |
| title_fullStr | Diagnostic accuracy of MRI-based radiomic features for EGFR mutation status in non-small cell lung cancer patients with brain metastases: a meta-analysis |
| title_full_unstemmed | Diagnostic accuracy of MRI-based radiomic features for EGFR mutation status in non-small cell lung cancer patients with brain metastases: a meta-analysis |
| title_short | Diagnostic accuracy of MRI-based radiomic features for EGFR mutation status in non-small cell lung cancer patients with brain metastases: a meta-analysis |
| title_sort | diagnostic accuracy of mri based radiomic features for egfr mutation status in non small cell lung cancer patients with brain metastases a meta analysis |
| topic | MRI radiomics non-small cell lung cancer brain metastases EGFR mutations |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2024.1428929/full |
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