Unlocking the potential: very-low-energy ketogenic therapy in obesity-related disorders
The Very Low-Energy Ketogenic Therapy (VLEKT) is a structured, multi-phase dietary regimen characterized by a carbohydrate intake of less than 50 g/day and a daily caloric intake of fewer than 800 kcal, which induces ketosis and facilitates significant weight loss. Evidence suggests that this nutrit...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2025-12-01
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| Series: | Food and Agricultural Immunology |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/09540105.2024.2442368 |
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| author | Daniel Simancas-Racines Claudia Reytor-González Ana Karina Zambrano Giuseppe Annunziata Angelo Michele Carella Ludovica Verde Evelyn Frias-Toral Claudia V. Guerra Ricardo Hidalgo |
| author_facet | Daniel Simancas-Racines Claudia Reytor-González Ana Karina Zambrano Giuseppe Annunziata Angelo Michele Carella Ludovica Verde Evelyn Frias-Toral Claudia V. Guerra Ricardo Hidalgo |
| author_sort | Daniel Simancas-Racines |
| collection | DOAJ |
| description | The Very Low-Energy Ketogenic Therapy (VLEKT) is a structured, multi-phase dietary regimen characterized by a carbohydrate intake of less than 50 g/day and a daily caloric intake of fewer than 800 kcal, which induces ketosis and facilitates significant weight loss. Evidence suggests that this nutritional therapy can improve glycemic control, lipid profiles, and blood pressure, making it a promising option for managing type 2 diabetes (T2D) and reducing cardiovascular risk. These benefits are achieved through reductions in triglycerides and low-density lipoprotein cholesterol (LDL-c), alongside increases in high-density lipoprotein cholesterol (HDL-c). However, the effects of the VLEKT on lipid metabolism remain controversial. The review emphasizes the urgent need for further research to validate the long-term safety and efficacy of the VLEKT. It also highlights the critical role of personalized dietary plans, supervised by healthcare professionals, to optimize health outcomes and address individual patient needs. |
| format | Article |
| id | doaj-art-ede740c5c5954965990a5a0ff21e1fef |
| institution | Kabale University |
| issn | 0954-0105 1465-3443 |
| language | English |
| publishDate | 2025-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Food and Agricultural Immunology |
| spelling | doaj-art-ede740c5c5954965990a5a0ff21e1fef2025-01-16T14:51:44ZengTaylor & Francis GroupFood and Agricultural Immunology0954-01051465-34432025-12-0136110.1080/09540105.2024.2442368Unlocking the potential: very-low-energy ketogenic therapy in obesity-related disordersDaniel Simancas-Racines0Claudia Reytor-González1Ana Karina Zambrano2Giuseppe Annunziata3Angelo Michele Carella4Ludovica Verde5Evelyn Frias-Toral6Claudia V. Guerra7Ricardo Hidalgo8Universidad UTE, Facultad de Ciencias de la Salud Eugenio Espejo, Centro de Investigación en Salud Pública y Epidemiología Clínica (CISPEC), Quito, EcuadorUniversidad UTE, Facultad de Ciencias de la Salud Eugenio Espejo, Centro de Investigación en Salud Pública y Epidemiología Clínica (CISPEC), Quito, EcuadorUniversidad UTE, Facultad de Ciencias de la Salud Eugenio Espejo, Centro de Investigación Genética y Genómica, Quito, EcuadorFacoltà di Scienze Umane, della Formazione e dello Sport, Università Telematica Pegaso, Naples, ItalyInternal Medicine Department, “T. Masselli-Mascia” Hospital – San Severo, Foggia, ItalyDepartment of Public Health, University of Naples Federico II, Naples, ItalyUniversidad Espíritu Santo, Samborondón, EcuadorUniversidad UTE, Facultad de Ciencias de la Salud Eugenio Espejo, Centro de Investigación en Salud Pública y Epidemiología Clínica (CISPEC), Quito, EcuadorUniversidad UTE, Facultad de Ciencias de la Salud Eugenio Espejo, Centro de Investigación en Salud Pública y Epidemiología Clínica (CISPEC), Quito, EcuadorThe Very Low-Energy Ketogenic Therapy (VLEKT) is a structured, multi-phase dietary regimen characterized by a carbohydrate intake of less than 50 g/day and a daily caloric intake of fewer than 800 kcal, which induces ketosis and facilitates significant weight loss. Evidence suggests that this nutritional therapy can improve glycemic control, lipid profiles, and blood pressure, making it a promising option for managing type 2 diabetes (T2D) and reducing cardiovascular risk. These benefits are achieved through reductions in triglycerides and low-density lipoprotein cholesterol (LDL-c), alongside increases in high-density lipoprotein cholesterol (HDL-c). However, the effects of the VLEKT on lipid metabolism remain controversial. The review emphasizes the urgent need for further research to validate the long-term safety and efficacy of the VLEKT. It also highlights the critical role of personalized dietary plans, supervised by healthcare professionals, to optimize health outcomes and address individual patient needs.https://www.tandfonline.com/doi/10.1080/09540105.2024.2442368Very-Low-Energy Ketogenic TherapyVLEKTobesity-related disorderscardiovascular diseaseschronic diseasesgood health and well-being |
| spellingShingle | Daniel Simancas-Racines Claudia Reytor-González Ana Karina Zambrano Giuseppe Annunziata Angelo Michele Carella Ludovica Verde Evelyn Frias-Toral Claudia V. Guerra Ricardo Hidalgo Unlocking the potential: very-low-energy ketogenic therapy in obesity-related disorders Food and Agricultural Immunology Very-Low-Energy Ketogenic Therapy VLEKT obesity-related disorders cardiovascular diseases chronic diseases good health and well-being |
| title | Unlocking the potential: very-low-energy ketogenic therapy in obesity-related disorders |
| title_full | Unlocking the potential: very-low-energy ketogenic therapy in obesity-related disorders |
| title_fullStr | Unlocking the potential: very-low-energy ketogenic therapy in obesity-related disorders |
| title_full_unstemmed | Unlocking the potential: very-low-energy ketogenic therapy in obesity-related disorders |
| title_short | Unlocking the potential: very-low-energy ketogenic therapy in obesity-related disorders |
| title_sort | unlocking the potential very low energy ketogenic therapy in obesity related disorders |
| topic | Very-Low-Energy Ketogenic Therapy VLEKT obesity-related disorders cardiovascular diseases chronic diseases good health and well-being |
| url | https://www.tandfonline.com/doi/10.1080/09540105.2024.2442368 |
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