The adverse effects of metabolic disorder on left ventricular myocardial mechano-energetic efficiency and dysfunction in ischemic cardiomyopathy: insight from a cardiac MRI study
Abstract Purpose Metabolic risk factors (MetF) have emerged as the leading drivers of ischemic cardiomyopathy (ICM) worldwide. However, in patients who have already experienced myocardial ischemia/infarction, whether and in what pattern the MetF act on the heart needs to be further elucidated. This...
Saved in:
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2025-07-01
|
| Series: | Cardiovascular Diabetology |
| Online Access: | https://doi.org/10.1186/s12933-025-02817-2 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849335253876867072 |
|---|---|
| author | Li Jiang Yuan Li Xue-Ming Li Ke Shi Han Fang Wei‑Feng Yan Ying‑Kun Guo Hua‑Yan Xu Zhi-Gang Yang |
| author_facet | Li Jiang Yuan Li Xue-Ming Li Ke Shi Han Fang Wei‑Feng Yan Ying‑Kun Guo Hua‑Yan Xu Zhi-Gang Yang |
| author_sort | Li Jiang |
| collection | DOAJ |
| description | Abstract Purpose Metabolic risk factors (MetF) have emerged as the leading drivers of ischemic cardiomyopathy (ICM) worldwide. However, in patients who have already experienced myocardial ischemia/infarction, whether and in what pattern the MetF act on the heart needs to be further elucidated. This study aims to determine the adverse effects of MetF on left ventricular (LV) indexed myocardial mechano-energetic efficiency (MEEi) and dysfunction in patients with ICM, and further clarify which MetF classification is more clinically significant. Materials and methods This study retrospectively included 201 patients with ICM who underwent cardiac magnetic resonance imaging (MRI) examinations, and further divided them into the following three groups according to the number of coexisting MetF: The groups with no MetF (MetF-0 group, n = 32), with 1–2 MetF (MetF-1, n = 92) and with 3–5 MetF (MetF-2, n = 77). The clinical variables and MRI-derived parameters were measured and compared among the three groups. Multivariate linear regression analysis was performed to determine independent correlation of MetF on LV MEEi and strain in ICM patients. Results LV global circumferential peak strain (PS) gradually decreased from MetF-0 group, through MetF-1 group, to MetF-2 group (− 9.52 ± 2.70% vs. − 7.62 ± 2.73% vs. − 6.50 ± 2.70%, P < 0.001). MetF-1 and MetF-2 groups both showed lower MEEi, lower LV global radial and longitudinal PS than MetF-0 group (Both P < 0.001), while there was no statistically significant difference between MetF-1 and MetF-2 groups (P > 0.05). Multivariate analyses indicated that the coexisting any MetF was independently associated with decreased LV MEEi (β = − 0.093, P = 0.018) and PS (Radial, β = − 0.232, P < 0.001; Circumferential, β = 0.156, P = 0.002; Longitudinal, β = 0.192, P = 0.008), and the increase in the number of coexisting MetF was only related to the reduction of circumferential PS (β = 0.238, P = 0.006). Conclusions Our results revealed whether coexisting any MetF, rather than coexisting a greater number of MetF, is associated with the reduction of LV myocardial mechano-energetic efficiency and dysfunction in patients with ICM, suggesting that clinicians should promptly identify and treat any coexisting MetF in the management of ICM patients. Graphical abstract |
| format | Article |
| id | doaj-art-eddffc932ef8413fbb01f5ba61333617 |
| institution | Kabale University |
| issn | 1475-2840 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | BMC |
| record_format | Article |
| series | Cardiovascular Diabetology |
| spelling | doaj-art-eddffc932ef8413fbb01f5ba613336172025-08-20T03:45:22ZengBMCCardiovascular Diabetology1475-28402025-07-0124111310.1186/s12933-025-02817-2The adverse effects of metabolic disorder on left ventricular myocardial mechano-energetic efficiency and dysfunction in ischemic cardiomyopathy: insight from a cardiac MRI studyLi Jiang0Yuan Li1Xue-Ming Li2Ke Shi3Han Fang4Wei‑Feng Yan5Ying‑Kun Guo6Hua‑Yan Xu7Zhi-Gang Yang8Department of Radiology, West China Hospital, Sichuan UniversityDepartment of Radiology, West China Hospital, Sichuan UniversityDepartment of Radiology, West China Hospital, Sichuan UniversityDepartment of Radiology, West China Hospital, Sichuan UniversityDepartment of Radiology, West China Hospital, Sichuan UniversityDepartment of Radiology, West China Hospital, Sichuan UniversityDepartment of Radiology, Key Laboratory of Birth Defects and Related Diseases of Women and Children of Ministry of Education, West China Second University Hospital, Sichuan UniversityDepartment of Radiology, Key Laboratory of Birth Defects and Related Diseases of Women and Children of Ministry of Education, West China Second University Hospital, Sichuan UniversityDepartment of Radiology, West China Hospital, Sichuan UniversityAbstract Purpose Metabolic risk factors (MetF) have emerged as the leading drivers of ischemic cardiomyopathy (ICM) worldwide. However, in patients who have already experienced myocardial ischemia/infarction, whether and in what pattern the MetF act on the heart needs to be further elucidated. This study aims to determine the adverse effects of MetF on left ventricular (LV) indexed myocardial mechano-energetic efficiency (MEEi) and dysfunction in patients with ICM, and further clarify which MetF classification is more clinically significant. Materials and methods This study retrospectively included 201 patients with ICM who underwent cardiac magnetic resonance imaging (MRI) examinations, and further divided them into the following three groups according to the number of coexisting MetF: The groups with no MetF (MetF-0 group, n = 32), with 1–2 MetF (MetF-1, n = 92) and with 3–5 MetF (MetF-2, n = 77). The clinical variables and MRI-derived parameters were measured and compared among the three groups. Multivariate linear regression analysis was performed to determine independent correlation of MetF on LV MEEi and strain in ICM patients. Results LV global circumferential peak strain (PS) gradually decreased from MetF-0 group, through MetF-1 group, to MetF-2 group (− 9.52 ± 2.70% vs. − 7.62 ± 2.73% vs. − 6.50 ± 2.70%, P < 0.001). MetF-1 and MetF-2 groups both showed lower MEEi, lower LV global radial and longitudinal PS than MetF-0 group (Both P < 0.001), while there was no statistically significant difference between MetF-1 and MetF-2 groups (P > 0.05). Multivariate analyses indicated that the coexisting any MetF was independently associated with decreased LV MEEi (β = − 0.093, P = 0.018) and PS (Radial, β = − 0.232, P < 0.001; Circumferential, β = 0.156, P = 0.002; Longitudinal, β = 0.192, P = 0.008), and the increase in the number of coexisting MetF was only related to the reduction of circumferential PS (β = 0.238, P = 0.006). Conclusions Our results revealed whether coexisting any MetF, rather than coexisting a greater number of MetF, is associated with the reduction of LV myocardial mechano-energetic efficiency and dysfunction in patients with ICM, suggesting that clinicians should promptly identify and treat any coexisting MetF in the management of ICM patients. Graphical abstracthttps://doi.org/10.1186/s12933-025-02817-2 |
| spellingShingle | Li Jiang Yuan Li Xue-Ming Li Ke Shi Han Fang Wei‑Feng Yan Ying‑Kun Guo Hua‑Yan Xu Zhi-Gang Yang The adverse effects of metabolic disorder on left ventricular myocardial mechano-energetic efficiency and dysfunction in ischemic cardiomyopathy: insight from a cardiac MRI study Cardiovascular Diabetology |
| title | The adverse effects of metabolic disorder on left ventricular myocardial mechano-energetic efficiency and dysfunction in ischemic cardiomyopathy: insight from a cardiac MRI study |
| title_full | The adverse effects of metabolic disorder on left ventricular myocardial mechano-energetic efficiency and dysfunction in ischemic cardiomyopathy: insight from a cardiac MRI study |
| title_fullStr | The adverse effects of metabolic disorder on left ventricular myocardial mechano-energetic efficiency and dysfunction in ischemic cardiomyopathy: insight from a cardiac MRI study |
| title_full_unstemmed | The adverse effects of metabolic disorder on left ventricular myocardial mechano-energetic efficiency and dysfunction in ischemic cardiomyopathy: insight from a cardiac MRI study |
| title_short | The adverse effects of metabolic disorder on left ventricular myocardial mechano-energetic efficiency and dysfunction in ischemic cardiomyopathy: insight from a cardiac MRI study |
| title_sort | adverse effects of metabolic disorder on left ventricular myocardial mechano energetic efficiency and dysfunction in ischemic cardiomyopathy insight from a cardiac mri study |
| url | https://doi.org/10.1186/s12933-025-02817-2 |
| work_keys_str_mv | AT lijiang theadverseeffectsofmetabolicdisorderonleftventricularmyocardialmechanoenergeticefficiencyanddysfunctioninischemiccardiomyopathyinsightfromacardiacmristudy AT yuanli theadverseeffectsofmetabolicdisorderonleftventricularmyocardialmechanoenergeticefficiencyanddysfunctioninischemiccardiomyopathyinsightfromacardiacmristudy AT xuemingli theadverseeffectsofmetabolicdisorderonleftventricularmyocardialmechanoenergeticefficiencyanddysfunctioninischemiccardiomyopathyinsightfromacardiacmristudy AT keshi theadverseeffectsofmetabolicdisorderonleftventricularmyocardialmechanoenergeticefficiencyanddysfunctioninischemiccardiomyopathyinsightfromacardiacmristudy AT hanfang theadverseeffectsofmetabolicdisorderonleftventricularmyocardialmechanoenergeticefficiencyanddysfunctioninischemiccardiomyopathyinsightfromacardiacmristudy AT weifengyan theadverseeffectsofmetabolicdisorderonleftventricularmyocardialmechanoenergeticefficiencyanddysfunctioninischemiccardiomyopathyinsightfromacardiacmristudy AT yingkunguo theadverseeffectsofmetabolicdisorderonleftventricularmyocardialmechanoenergeticefficiencyanddysfunctioninischemiccardiomyopathyinsightfromacardiacmristudy AT huayanxu theadverseeffectsofmetabolicdisorderonleftventricularmyocardialmechanoenergeticefficiencyanddysfunctioninischemiccardiomyopathyinsightfromacardiacmristudy AT zhigangyang theadverseeffectsofmetabolicdisorderonleftventricularmyocardialmechanoenergeticefficiencyanddysfunctioninischemiccardiomyopathyinsightfromacardiacmristudy AT lijiang adverseeffectsofmetabolicdisorderonleftventricularmyocardialmechanoenergeticefficiencyanddysfunctioninischemiccardiomyopathyinsightfromacardiacmristudy AT yuanli adverseeffectsofmetabolicdisorderonleftventricularmyocardialmechanoenergeticefficiencyanddysfunctioninischemiccardiomyopathyinsightfromacardiacmristudy AT xuemingli adverseeffectsofmetabolicdisorderonleftventricularmyocardialmechanoenergeticefficiencyanddysfunctioninischemiccardiomyopathyinsightfromacardiacmristudy AT keshi adverseeffectsofmetabolicdisorderonleftventricularmyocardialmechanoenergeticefficiencyanddysfunctioninischemiccardiomyopathyinsightfromacardiacmristudy AT hanfang adverseeffectsofmetabolicdisorderonleftventricularmyocardialmechanoenergeticefficiencyanddysfunctioninischemiccardiomyopathyinsightfromacardiacmristudy AT weifengyan adverseeffectsofmetabolicdisorderonleftventricularmyocardialmechanoenergeticefficiencyanddysfunctioninischemiccardiomyopathyinsightfromacardiacmristudy AT yingkunguo adverseeffectsofmetabolicdisorderonleftventricularmyocardialmechanoenergeticefficiencyanddysfunctioninischemiccardiomyopathyinsightfromacardiacmristudy AT huayanxu adverseeffectsofmetabolicdisorderonleftventricularmyocardialmechanoenergeticefficiencyanddysfunctioninischemiccardiomyopathyinsightfromacardiacmristudy AT zhigangyang adverseeffectsofmetabolicdisorderonleftventricularmyocardialmechanoenergeticefficiencyanddysfunctioninischemiccardiomyopathyinsightfromacardiacmristudy |