Effects of natural products on macrophage immunometabolism: A new frontier in the treatment of metabolic diseases
Immunometabolic variations in macrophages critically influence their differentiation into pro-inflammatory or anti-inflammatory phenotypes, thereby contributing to immune homeostasis, defense against infection, and tissue repair. Dysregulation of macrophage immunometabolism has been closely implicat...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-03-01
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| Series: | Pharmacological Research |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1043661825000593 |
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| author | Jiani Li Chen Guo Xiaofei Yang Weinan Xie Wenjing Mi Chenglong Hua Cheng Tang Han Wang |
| author_facet | Jiani Li Chen Guo Xiaofei Yang Weinan Xie Wenjing Mi Chenglong Hua Cheng Tang Han Wang |
| author_sort | Jiani Li |
| collection | DOAJ |
| description | Immunometabolic variations in macrophages critically influence their differentiation into pro-inflammatory or anti-inflammatory phenotypes, thereby contributing to immune homeostasis, defense against infection, and tissue repair. Dysregulation of macrophage immunometabolism has been closely implicated in several metabolic diseases, including obesity, type 2 diabetes mellitus (T2DM), non-alcoholic fatty liver disease (NAFLD), hypertension, atherosclerosis, and gout, which positions macrophages as potential therapeutic targets. Recently, several natural products that target macrophage metabolic pathways have shown significant efficacy in managing metabolic diseases; however, a systematic review of these findings has yet to be conducted. This study consolidates natural products with immunoregulatory properties, including flavonoids, phenols, terpenoids, and naphthoquinones, which can alleviate chronic inflammation associated with metabolic disorders by modulating macrophage metabolic pathways, such as aerobic glycolysis, oxidative phosphorylation (OXPHOS), and fatty acid oxidation (FAO). This review aims to elucidate the metabolic regulation of the immune system, analyze metabolic alterations in macrophage associated with metabolic diseases, and summarize the beneficial roles of natural products in immunometabolism, providing novel insights for the prevention and therapeutic management of metabolic diseases. |
| format | Article |
| id | doaj-art-eddce0e3bb784240954dbfaef9d41282 |
| institution | Kabale University |
| issn | 1096-1186 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Pharmacological Research |
| spelling | doaj-art-eddce0e3bb784240954dbfaef9d412822025-02-03T04:16:29ZengElsevierPharmacological Research1096-11862025-03-01213107634Effects of natural products on macrophage immunometabolism: A new frontier in the treatment of metabolic diseasesJiani Li0Chen Guo1Xiaofei Yang2Weinan Xie3Wenjing Mi4Chenglong Hua5Cheng Tang6Han Wang7Beijing Academy of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing 100029, ChinaBeijing Academy of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing 100029, ChinaBeijing University of Chinese Medicine, Beijing 100029, ChinaBeijing University of Chinese Medicine, Beijing 100029, ChinaGuang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing 100053, ChinaSchool of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, ChinaBeijing Academy of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing 100029, China; Corresponding authors.School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 100029, China; Corresponding authors.Immunometabolic variations in macrophages critically influence their differentiation into pro-inflammatory or anti-inflammatory phenotypes, thereby contributing to immune homeostasis, defense against infection, and tissue repair. Dysregulation of macrophage immunometabolism has been closely implicated in several metabolic diseases, including obesity, type 2 diabetes mellitus (T2DM), non-alcoholic fatty liver disease (NAFLD), hypertension, atherosclerosis, and gout, which positions macrophages as potential therapeutic targets. Recently, several natural products that target macrophage metabolic pathways have shown significant efficacy in managing metabolic diseases; however, a systematic review of these findings has yet to be conducted. This study consolidates natural products with immunoregulatory properties, including flavonoids, phenols, terpenoids, and naphthoquinones, which can alleviate chronic inflammation associated with metabolic disorders by modulating macrophage metabolic pathways, such as aerobic glycolysis, oxidative phosphorylation (OXPHOS), and fatty acid oxidation (FAO). This review aims to elucidate the metabolic regulation of the immune system, analyze metabolic alterations in macrophage associated with metabolic diseases, and summarize the beneficial roles of natural products in immunometabolism, providing novel insights for the prevention and therapeutic management of metabolic diseases.http://www.sciencedirect.com/science/article/pii/S1043661825000593Natural productsImmunometabolismMacrophagesMetabolic diseasesMetabolic pathways |
| spellingShingle | Jiani Li Chen Guo Xiaofei Yang Weinan Xie Wenjing Mi Chenglong Hua Cheng Tang Han Wang Effects of natural products on macrophage immunometabolism: A new frontier in the treatment of metabolic diseases Pharmacological Research Natural products Immunometabolism Macrophages Metabolic diseases Metabolic pathways |
| title | Effects of natural products on macrophage immunometabolism: A new frontier in the treatment of metabolic diseases |
| title_full | Effects of natural products on macrophage immunometabolism: A new frontier in the treatment of metabolic diseases |
| title_fullStr | Effects of natural products on macrophage immunometabolism: A new frontier in the treatment of metabolic diseases |
| title_full_unstemmed | Effects of natural products on macrophage immunometabolism: A new frontier in the treatment of metabolic diseases |
| title_short | Effects of natural products on macrophage immunometabolism: A new frontier in the treatment of metabolic diseases |
| title_sort | effects of natural products on macrophage immunometabolism a new frontier in the treatment of metabolic diseases |
| topic | Natural products Immunometabolism Macrophages Metabolic diseases Metabolic pathways |
| url | http://www.sciencedirect.com/science/article/pii/S1043661825000593 |
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