Nucleolar organizer regions indicators hepatocytes in experimental thyrotoxicosis
On laboratory animals receded experimental model of hyperthyroidism. Work carded out on 46 white male rats of Wistar weighing 250-300 g. Laboratory animals administered daily L-thyroxine in a dose of 1,6 mg per 1 kg of body weight. Rats were taken out of the experience through 7, 14, 21, 28, 45, 60...
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| Language: | Russian |
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Ministry of Healthcare of the Russian Federation. “Kuban State Medical University”
2014-08-01
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| Series: | Кубанский научный медицинский вестник |
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| Online Access: | https://ksma.elpub.ru/jour/article/view/171 |
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| author | V. S. Botasheva N. A. Stadnyk |
| author_facet | V. S. Botasheva N. A. Stadnyk |
| author_sort | V. S. Botasheva |
| collection | DOAJ |
| description | On laboratory animals receded experimental model of hyperthyroidism. Work carded out on 46 white male rats of Wistar weighing 250-300 g. Laboratory animals administered daily L-thyroxine in a dose of 1,6 mg per 1 kg of body weight. Rats were taken out of the experience through 7, 14, 21, 28, 45, 60 and 90 days. To determine the level of thyroid hormone blood sampling was carried out from tail vein. Conducted macroscopic and microscopic examination of the liver. The experimental results showed that the daily administration of L-thyroxine observed increase in the level of thyroid hormones (T4, T3) in the blood and a decrease in thyroid stimulating hormone (TSH). Histological examination of the liver revealed diffuse hydropic and ballooning degeneration of hepatocytes, colliquative necrosis areas with the formation of cavities, diffuse perisinusoidal edema, lymphocytic infiltration. When stained with nitro acid silver identified nucleolar organizers. Marked increase in the number of nucleolar organizer regions in experimental thyrotoxicosis on the 28th day and the gradual reduction of the end of the experiment. |
| format | Article |
| id | doaj-art-eddc654892e24f718f9cea71b69d096f |
| institution | Kabale University |
| issn | 1608-6228 2541-9544 |
| language | Russian |
| publishDate | 2014-08-01 |
| publisher | Ministry of Healthcare of the Russian Federation. “Kuban State Medical University” |
| record_format | Article |
| series | Кубанский научный медицинский вестник |
| spelling | doaj-art-eddc654892e24f718f9cea71b69d096f2025-08-20T03:57:21ZrusMinistry of Healthcare of the Russian Federation. “Kuban State Medical University”Кубанский научный медицинский вестник1608-62282541-95442014-08-0142430171Nucleolar organizer regions indicators hepatocytes in experimental thyrotoxicosisV. S. Botasheva0N. A. Stadnyk1ГБОУ ВПО «Ставропольский государственный медицинский университет» Минздрава РоссииГБОУ ВПО «Ставропольский государственный медицинский университет» Минздрава РоссииOn laboratory animals receded experimental model of hyperthyroidism. Work carded out on 46 white male rats of Wistar weighing 250-300 g. Laboratory animals administered daily L-thyroxine in a dose of 1,6 mg per 1 kg of body weight. Rats were taken out of the experience through 7, 14, 21, 28, 45, 60 and 90 days. To determine the level of thyroid hormone blood sampling was carried out from tail vein. Conducted macroscopic and microscopic examination of the liver. The experimental results showed that the daily administration of L-thyroxine observed increase in the level of thyroid hormones (T4, T3) in the blood and a decrease in thyroid stimulating hormone (TSH). Histological examination of the liver revealed diffuse hydropic and ballooning degeneration of hepatocytes, colliquative necrosis areas with the formation of cavities, diffuse perisinusoidal edema, lymphocytic infiltration. When stained with nitro acid silver identified nucleolar organizers. Marked increase in the number of nucleolar organizer regions in experimental thyrotoxicosis on the 28th day and the gradual reduction of the end of the experiment.https://ksma.elpub.ru/jour/article/view/171щитовидная железатиреотоксикозпеченьгидропическая дистрофияперисинусоидальный отекобласти ядрышковых организаторов гепатоцитовthyroidhyperthyroidismliverhydropic degenerationperisinusoidal edemanucleolar organizer region of hepatocytes |
| spellingShingle | V. S. Botasheva N. A. Stadnyk Nucleolar organizer regions indicators hepatocytes in experimental thyrotoxicosis Кубанский научный медицинский вестник щитовидная железа тиреотоксикоз печень гидропическая дистрофия перисинусоидальный отек области ядрышковых организаторов гепатоцитов thyroid hyperthyroidism liver hydropic degeneration perisinusoidal edema nucleolar organizer region of hepatocytes |
| title | Nucleolar organizer regions indicators hepatocytes in experimental thyrotoxicosis |
| title_full | Nucleolar organizer regions indicators hepatocytes in experimental thyrotoxicosis |
| title_fullStr | Nucleolar organizer regions indicators hepatocytes in experimental thyrotoxicosis |
| title_full_unstemmed | Nucleolar organizer regions indicators hepatocytes in experimental thyrotoxicosis |
| title_short | Nucleolar organizer regions indicators hepatocytes in experimental thyrotoxicosis |
| title_sort | nucleolar organizer regions indicators hepatocytes in experimental thyrotoxicosis |
| topic | щитовидная железа тиреотоксикоз печень гидропическая дистрофия перисинусоидальный отек области ядрышковых организаторов гепатоцитов thyroid hyperthyroidism liver hydropic degeneration perisinusoidal edema nucleolar organizer region of hepatocytes |
| url | https://ksma.elpub.ru/jour/article/view/171 |
| work_keys_str_mv | AT vsbotasheva nucleolarorganizerregionsindicatorshepatocytesinexperimentalthyrotoxicosis AT nastadnyk nucleolarorganizerregionsindicatorshepatocytesinexperimentalthyrotoxicosis |