Central Pain in Parkinson’s Disease: Behavioral and Cognitive Characteristics
Introduction. Pain is a major nonmotor symptom of Parkinson’s disease (PD), and central parkinsonian pain is the core feature of the putative Park pain subtype of PD. This study aimed to explore the cognitive and behavioral profile of PD patients with central parkinsonian pain. Material and Methods....
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| Format: | Article |
| Language: | English |
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Wiley
2021-01-01
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| Series: | Parkinson's Disease |
| Online Access: | http://dx.doi.org/10.1155/2021/5553460 |
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| author | N. Vila-Chã S. Cavaco A. Mendes A. Gonçalves I. Moreira J. Fernandes J. Damásio L. F. Azevedo J. M. Castro-Lopes |
| author_facet | N. Vila-Chã S. Cavaco A. Mendes A. Gonçalves I. Moreira J. Fernandes J. Damásio L. F. Azevedo J. M. Castro-Lopes |
| author_sort | N. Vila-Chã |
| collection | DOAJ |
| description | Introduction. Pain is a major nonmotor symptom of Parkinson’s disease (PD), and central parkinsonian pain is the core feature of the putative Park pain subtype of PD. This study aimed to explore the cognitive and behavioral profile of PD patients with central parkinsonian pain. Material and Methods. A structured interview was used to identify and characterize pain in a cohort of 260 consecutive PD patients. The Ford classification of pain was applied. The Dementia Rating Scale-2 (DRS-2) and the Impulse Control Disorders in Parkinson’s Disease Short Form (QUIP-S) were administered, and patients’ smoking habits were recorded. The Unified Parkinson’s Disease Rating Scale (UPDRS) was used to assess motor and nonmotor symptoms in off and on conditions. Results. One hundred and eighty-eight patients (68%) reported pain; and in 41 (22%) of them, the pain was classified as central parkinsonian pain. PD patients with central parkinsonian pain had better cognitive performance in DRS-2 Initiation/Perseveration and Conceptualization subscales but reported more other compulsive behaviors (e.g., hobbyism, punding, and walkabout) and had more current smoking habits than those without pain or with non-central parkinsonian pain. Multiple logistic regression analyses revealed that the DRS-2 Conceptualization subscale, other compulsive behaviors, and smoking habits remained statistically associated with central parkinsonian pain even when other significant covariates were considered. Only patients with pain, regardless of type, had a gambling disorder. Discussion. The study results provide further evidence that pain revealed that patients with central parkinsonian pain are more likely to present compulsive or addictive behaviors, despite having more preserved cognitive performance. Patients with central parkinsonian pain appear to have a distinct phenotype of PD. |
| format | Article |
| id | doaj-art-eddb5673bde74519a9c725f0e3e7ac9b |
| institution | Kabale University |
| issn | 2090-8083 2042-0080 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Parkinson's Disease |
| spelling | doaj-art-eddb5673bde74519a9c725f0e3e7ac9b2025-02-03T05:44:51ZengWileyParkinson's Disease2090-80832042-00802021-01-01202110.1155/2021/55534605553460Central Pain in Parkinson’s Disease: Behavioral and Cognitive CharacteristicsN. Vila-Chã0S. Cavaco1A. Mendes2A. Gonçalves3I. Moreira4J. Fernandes5J. Damásio6L. F. Azevedo7J. M. Castro-Lopes8Department of Neurology, Centro Hospitalar Universitário do Porto, Porto, PortugalDepartment of Neurology, Centro Hospitalar Universitário do Porto, Porto, PortugalDepartment of Neurology, Centro Hospitalar Universitário do Porto, Porto, PortugalDepartment of Neurology, Centro Hospitalar Universitário do Porto, Porto, PortugalDepartment of Neurology, Centro Hospitalar Universitário do Porto, Porto, PortugalLaboratory of Neurobiology of Human Behavior, Centro Hospitalar Universitário do Porto, Porto, PortugalDepartment of Neurology, Centro Hospitalar Universitário do Porto, Porto, PortugalCentre for Health Technology and Services Research (CINTESIS), University of Porto, Porto, PortugalNational Observatory for Pain–NOPain, Faculty of Medicine, University of Porto, Porto, PortugalIntroduction. Pain is a major nonmotor symptom of Parkinson’s disease (PD), and central parkinsonian pain is the core feature of the putative Park pain subtype of PD. This study aimed to explore the cognitive and behavioral profile of PD patients with central parkinsonian pain. Material and Methods. A structured interview was used to identify and characterize pain in a cohort of 260 consecutive PD patients. The Ford classification of pain was applied. The Dementia Rating Scale-2 (DRS-2) and the Impulse Control Disorders in Parkinson’s Disease Short Form (QUIP-S) were administered, and patients’ smoking habits were recorded. The Unified Parkinson’s Disease Rating Scale (UPDRS) was used to assess motor and nonmotor symptoms in off and on conditions. Results. One hundred and eighty-eight patients (68%) reported pain; and in 41 (22%) of them, the pain was classified as central parkinsonian pain. PD patients with central parkinsonian pain had better cognitive performance in DRS-2 Initiation/Perseveration and Conceptualization subscales but reported more other compulsive behaviors (e.g., hobbyism, punding, and walkabout) and had more current smoking habits than those without pain or with non-central parkinsonian pain. Multiple logistic regression analyses revealed that the DRS-2 Conceptualization subscale, other compulsive behaviors, and smoking habits remained statistically associated with central parkinsonian pain even when other significant covariates were considered. Only patients with pain, regardless of type, had a gambling disorder. Discussion. The study results provide further evidence that pain revealed that patients with central parkinsonian pain are more likely to present compulsive or addictive behaviors, despite having more preserved cognitive performance. Patients with central parkinsonian pain appear to have a distinct phenotype of PD.http://dx.doi.org/10.1155/2021/5553460 |
| spellingShingle | N. Vila-Chã S. Cavaco A. Mendes A. Gonçalves I. Moreira J. Fernandes J. Damásio L. F. Azevedo J. M. Castro-Lopes Central Pain in Parkinson’s Disease: Behavioral and Cognitive Characteristics Parkinson's Disease |
| title | Central Pain in Parkinson’s Disease: Behavioral and Cognitive Characteristics |
| title_full | Central Pain in Parkinson’s Disease: Behavioral and Cognitive Characteristics |
| title_fullStr | Central Pain in Parkinson’s Disease: Behavioral and Cognitive Characteristics |
| title_full_unstemmed | Central Pain in Parkinson’s Disease: Behavioral and Cognitive Characteristics |
| title_short | Central Pain in Parkinson’s Disease: Behavioral and Cognitive Characteristics |
| title_sort | central pain in parkinson s disease behavioral and cognitive characteristics |
| url | http://dx.doi.org/10.1155/2021/5553460 |
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