The regulation of neuroinflammatory response after stroke by intestinal flora microorganisms
Ischemic stroke (IS) is a severe central nervous system disorder characterized by high incidence, disability, mortality, and recurrence rates, along with numerous complications. The microbiota-gut-brain axis (MGBA) represents a bidirectional communication pathway between the brain and the gut, which...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-06-01
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| Series: | Frontiers in Cellular and Infection Microbiology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcimb.2025.1594834/full |
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| author | Wanying Xie Xue Yan Xu Yang Haitao Sun Weimin Zhang Weimin Zhang |
| author_facet | Wanying Xie Xue Yan Xu Yang Haitao Sun Weimin Zhang Weimin Zhang |
| author_sort | Wanying Xie |
| collection | DOAJ |
| description | Ischemic stroke (IS) is a severe central nervous system disorder characterized by high incidence, disability, mortality, and recurrence rates, along with numerous complications. The microbiota-gut-brain axis (MGBA) represents a bidirectional communication pathway between the brain and the gut, which can influence the onset and progression of IS through neural, immunoregulatory, and gut metabolite pathways. Recent preclinical and clinical evidence supports the use of fecal microbiota transplantation (FMT), probiotics and prebiotics, dietary interventions, and antibiotics as strategies to suppress neuroinflammation in IS, protect the blood-brain barrier, modulate immune responses, and improve stroke outcomes. In this review, we summarize the manifestations of innate inflammation and adaptive immunity following the onset of IS, highlight the interactions between the MGBA and post-stroke neuroinflammation, and discuss current therapeutic measures, thus providing insights for the development of novel treatment strategies in the future. |
| format | Article |
| id | doaj-art-edd866a1b74742a0a7d930f7994089f2 |
| institution | DOAJ |
| issn | 2235-2988 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cellular and Infection Microbiology |
| spelling | doaj-art-edd866a1b74742a0a7d930f7994089f22025-08-20T03:22:39ZengFrontiers Media S.A.Frontiers in Cellular and Infection Microbiology2235-29882025-06-011510.3389/fcimb.2025.15948341594834The regulation of neuroinflammatory response after stroke by intestinal flora microorganismsWanying Xie0Xue Yan1Xu Yang2Haitao Sun3Weimin Zhang4Weimin Zhang5College of Integrated Traditional Chinese and Western Medicine, Changchun University of Chinese Medicine, Changchun, ChinaThe Department of Encephalopathy, The Third Clinical Hospital Affiliated to Changchun University of Traditional Chinese Medicine, Changchun, ChinaThe Department of Encephalopathy, The Third Clinical Hospital Affiliated to Changchun University of Traditional Chinese Medicine, Changchun, ChinaCollege of Integrated Traditional Chinese and Western Medicine, Changchun University of Chinese Medicine, Changchun, ChinaCollege of Integrated Traditional Chinese and Western Medicine, Changchun University of Chinese Medicine, Changchun, ChinaThe Department of Encephalopathy, The Third Clinical Hospital Affiliated to Changchun University of Traditional Chinese Medicine, Changchun, ChinaIschemic stroke (IS) is a severe central nervous system disorder characterized by high incidence, disability, mortality, and recurrence rates, along with numerous complications. The microbiota-gut-brain axis (MGBA) represents a bidirectional communication pathway between the brain and the gut, which can influence the onset and progression of IS through neural, immunoregulatory, and gut metabolite pathways. Recent preclinical and clinical evidence supports the use of fecal microbiota transplantation (FMT), probiotics and prebiotics, dietary interventions, and antibiotics as strategies to suppress neuroinflammation in IS, protect the blood-brain barrier, modulate immune responses, and improve stroke outcomes. In this review, we summarize the manifestations of innate inflammation and adaptive immunity following the onset of IS, highlight the interactions between the MGBA and post-stroke neuroinflammation, and discuss current therapeutic measures, thus providing insights for the development of novel treatment strategies in the future.https://www.frontiersin.org/articles/10.3389/fcimb.2025.1594834/fulldysbiosisgut microbiotaischemic strokemicrobiota-gut-brain axisneuroinflammation |
| spellingShingle | Wanying Xie Xue Yan Xu Yang Haitao Sun Weimin Zhang Weimin Zhang The regulation of neuroinflammatory response after stroke by intestinal flora microorganisms Frontiers in Cellular and Infection Microbiology dysbiosis gut microbiota ischemic stroke microbiota-gut-brain axis neuroinflammation |
| title | The regulation of neuroinflammatory response after stroke by intestinal flora microorganisms |
| title_full | The regulation of neuroinflammatory response after stroke by intestinal flora microorganisms |
| title_fullStr | The regulation of neuroinflammatory response after stroke by intestinal flora microorganisms |
| title_full_unstemmed | The regulation of neuroinflammatory response after stroke by intestinal flora microorganisms |
| title_short | The regulation of neuroinflammatory response after stroke by intestinal flora microorganisms |
| title_sort | regulation of neuroinflammatory response after stroke by intestinal flora microorganisms |
| topic | dysbiosis gut microbiota ischemic stroke microbiota-gut-brain axis neuroinflammation |
| url | https://www.frontiersin.org/articles/10.3389/fcimb.2025.1594834/full |
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