Immunological Barriers to Stem Cell Therapy in the Central Nervous System
The central nervous system is vulnerable to many neurodegenerative disorders such as Alzheimer’s disease that result in the extensive loss of neuronal cells. Stem cells have the ability to differentiate into many types of cells, which make them ideal for treating such disorders. Although stem cell t...
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| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2014-01-01
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| Series: | Stem Cells International |
| Online Access: | http://dx.doi.org/10.1155/2014/507905 |
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| _version_ | 1850165657071517696 |
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| author | Gregory E. Tullis Kathleen Spears Mark D. Kirk |
| author_facet | Gregory E. Tullis Kathleen Spears Mark D. Kirk |
| author_sort | Gregory E. Tullis |
| collection | DOAJ |
| description | The central nervous system is vulnerable to many neurodegenerative disorders such as Alzheimer’s disease that result in the extensive loss of neuronal cells. Stem cells have the ability to differentiate into many types of cells, which make them ideal for treating such disorders. Although stem cell therapy has shown some promising results in animal models for many brain disorders it has yet to translate into the clinic. A major hurdle to the translation of stem cell therapy into the clinic is the immune response faced by stem cell transplants. Here, we focus on immunological and related hurdles to stem cell therapies for central nervous system disorders. |
| format | Article |
| id | doaj-art-edd78b2ef7124a92ac2c8695f445bcb3 |
| institution | OA Journals |
| issn | 1687-966X 1687-9678 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Stem Cells International |
| spelling | doaj-art-edd78b2ef7124a92ac2c8695f445bcb32025-08-20T02:21:41ZengWileyStem Cells International1687-966X1687-96782014-01-01201410.1155/2014/507905507905Immunological Barriers to Stem Cell Therapy in the Central Nervous SystemGregory E. Tullis0Kathleen Spears1Mark D. Kirk2Division of Biological Sciences, University of Missouri, 102 LeFevre Hall, Columbia, MO 65211, USADepartment of Natural Sciences, Northwest Missouri State University, Maryville, MO 64468, USADivision of Biological Sciences, University of Missouri, 102 LeFevre Hall, Columbia, MO 65211, USAThe central nervous system is vulnerable to many neurodegenerative disorders such as Alzheimer’s disease that result in the extensive loss of neuronal cells. Stem cells have the ability to differentiate into many types of cells, which make them ideal for treating such disorders. Although stem cell therapy has shown some promising results in animal models for many brain disorders it has yet to translate into the clinic. A major hurdle to the translation of stem cell therapy into the clinic is the immune response faced by stem cell transplants. Here, we focus on immunological and related hurdles to stem cell therapies for central nervous system disorders.http://dx.doi.org/10.1155/2014/507905 |
| spellingShingle | Gregory E. Tullis Kathleen Spears Mark D. Kirk Immunological Barriers to Stem Cell Therapy in the Central Nervous System Stem Cells International |
| title | Immunological Barriers to Stem Cell Therapy in the Central Nervous System |
| title_full | Immunological Barriers to Stem Cell Therapy in the Central Nervous System |
| title_fullStr | Immunological Barriers to Stem Cell Therapy in the Central Nervous System |
| title_full_unstemmed | Immunological Barriers to Stem Cell Therapy in the Central Nervous System |
| title_short | Immunological Barriers to Stem Cell Therapy in the Central Nervous System |
| title_sort | immunological barriers to stem cell therapy in the central nervous system |
| url | http://dx.doi.org/10.1155/2014/507905 |
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