The Role of Post-Translational Modifications in Necroptosis
Necroptosis, a distinct form of regulated necrosis implicated in various human pathologies, is orchestrated through sophisticated signaling pathways. During this process, cells undergoing necroptosis exhibit characteristic necrotic morphology and provoke substantial inflammatory responses. Post-tran...
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| Language: | English |
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MDPI AG
2025-04-01
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| Series: | Biomolecules |
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| Online Access: | https://www.mdpi.com/2218-273X/15/4/549 |
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| author | Hao Xiao Zeping Han Min Xu Xukang Gao Shuangjian Qiu Ning Ren Yong Yi Chenhao Zhou |
| author_facet | Hao Xiao Zeping Han Min Xu Xukang Gao Shuangjian Qiu Ning Ren Yong Yi Chenhao Zhou |
| author_sort | Hao Xiao |
| collection | DOAJ |
| description | Necroptosis, a distinct form of regulated necrosis implicated in various human pathologies, is orchestrated through sophisticated signaling pathways. During this process, cells undergoing necroptosis exhibit characteristic necrotic morphology and provoke substantial inflammatory responses. Post-translational modifications (PTMs)—chemical alterations occurring after protein synthesis that critically regulate protein functionality—constitute essential regulatory components within these complex signaling cascades. This intricate crosstalk between necroptotic pathways and PTM networks presents promising therapeutic opportunities. Our comprehensive review systematically analyzes the molecular mechanisms underlying necroptosis, with particular emphasis on the regulatory roles of PTMs in signal transduction. Through systematic evaluation of key modifications including ubiquitination, phosphorylation, glycosylation, methylation, acetylation, disulfide bond formation, caspase cleavage, nitrosylation, and SUMOylation, we examine potential therapeutic applications targeting necroptosis in disease pathogenesis. Furthermore, we synthesize current pharmacological strategies for manipulating PTM-regulated necroptosis, offering novel perspectives on clinical target development and therapeutic intervention. |
| format | Article |
| id | doaj-art-edd3113644e24f1e86cd8fdc56e87921 |
| institution | OA Journals |
| issn | 2218-273X |
| language | English |
| publishDate | 2025-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomolecules |
| spelling | doaj-art-edd3113644e24f1e86cd8fdc56e879212025-08-20T02:24:42ZengMDPI AGBiomolecules2218-273X2025-04-0115454910.3390/biom15040549The Role of Post-Translational Modifications in NecroptosisHao Xiao0Zeping Han1Min Xu2Xukang Gao3Shuangjian Qiu4Ning Ren5Yong Yi6Chenhao Zhou7Department of Liver Surgery and Transplantation, Zhongshan Hospital, Fudan University, Shanghai 200032, ChinaDepartment of Liver Surgery and Transplantation, Zhongshan Hospital, Fudan University, Shanghai 200032, ChinaDepartment of Liver Surgery and Transplantation, Zhongshan Hospital, Fudan University, Shanghai 200032, ChinaDepartment of Liver Surgery and Transplantation, Zhongshan Hospital, Fudan University, Shanghai 200032, ChinaDepartment of Liver Surgery and Transplantation, Zhongshan Hospital, Fudan University, Shanghai 200032, ChinaDepartment of Liver Surgery and Transplantation, Zhongshan Hospital, Fudan University, Shanghai 200032, ChinaDepartment of Liver Surgery and Transplantation, Zhongshan Hospital, Fudan University, Shanghai 200032, ChinaDepartment of Liver Surgery and Transplantation, Zhongshan Hospital, Fudan University, Shanghai 200032, ChinaNecroptosis, a distinct form of regulated necrosis implicated in various human pathologies, is orchestrated through sophisticated signaling pathways. During this process, cells undergoing necroptosis exhibit characteristic necrotic morphology and provoke substantial inflammatory responses. Post-translational modifications (PTMs)—chemical alterations occurring after protein synthesis that critically regulate protein functionality—constitute essential regulatory components within these complex signaling cascades. This intricate crosstalk between necroptotic pathways and PTM networks presents promising therapeutic opportunities. Our comprehensive review systematically analyzes the molecular mechanisms underlying necroptosis, with particular emphasis on the regulatory roles of PTMs in signal transduction. Through systematic evaluation of key modifications including ubiquitination, phosphorylation, glycosylation, methylation, acetylation, disulfide bond formation, caspase cleavage, nitrosylation, and SUMOylation, we examine potential therapeutic applications targeting necroptosis in disease pathogenesis. Furthermore, we synthesize current pharmacological strategies for manipulating PTM-regulated necroptosis, offering novel perspectives on clinical target development and therapeutic intervention.https://www.mdpi.com/2218-273X/15/4/549necroptosispost-translational modifications (PTMs)targeted therapymechanism |
| spellingShingle | Hao Xiao Zeping Han Min Xu Xukang Gao Shuangjian Qiu Ning Ren Yong Yi Chenhao Zhou The Role of Post-Translational Modifications in Necroptosis Biomolecules necroptosis post-translational modifications (PTMs) targeted therapy mechanism |
| title | The Role of Post-Translational Modifications in Necroptosis |
| title_full | The Role of Post-Translational Modifications in Necroptosis |
| title_fullStr | The Role of Post-Translational Modifications in Necroptosis |
| title_full_unstemmed | The Role of Post-Translational Modifications in Necroptosis |
| title_short | The Role of Post-Translational Modifications in Necroptosis |
| title_sort | role of post translational modifications in necroptosis |
| topic | necroptosis post-translational modifications (PTMs) targeted therapy mechanism |
| url | https://www.mdpi.com/2218-273X/15/4/549 |
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