Germline variation in colorectal risk Loci does not influence treatment effect or survival in metastatic colorectal cancer.

Germline variation in colorectal risk Loci does not influence treatment effect or survival in metastatic colorectal cancer.

<h4>Background</h4>Colorectal cancer (CRC) risk is partly conferred by common, low-penetrance single nucleotide polymorphisms (SNPs). We hypothesized that these SNPs are associated with outcomes in metastatic CRC.<h4>Methods</h4>Six candidate SNPs from 8q24, 10p14, 15q13, 18q...

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Main Authors: Hanna K Sanoff, Lindsay A Renfro, Pradeep Poonnen, Pratibha Ambadwar, Daniel J Sargent, Richard M Goldberg, Howard McLeod
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0094727
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