Germline variation in colorectal risk Loci does not influence treatment effect or survival in metastatic colorectal cancer.
<h4>Background</h4>Colorectal cancer (CRC) risk is partly conferred by common, low-penetrance single nucleotide polymorphisms (SNPs). We hypothesized that these SNPs are associated with outcomes in metastatic CRC.<h4>Methods</h4>Six candidate SNPs from 8q24, 10p14, 15q13, 18q...
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2014-01-01
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| Series: | PLoS ONE |
| Online Access: | https://doi.org/10.1371/journal.pone.0094727 |
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| author | Hanna K Sanoff Lindsay A Renfro Pradeep Poonnen Pratibha Ambadwar Daniel J Sargent Richard M Goldberg Howard McLeod |
| author_facet | Hanna K Sanoff Lindsay A Renfro Pradeep Poonnen Pratibha Ambadwar Daniel J Sargent Richard M Goldberg Howard McLeod |
| author_sort | Hanna K Sanoff |
| collection | DOAJ |
| description | <h4>Background</h4>Colorectal cancer (CRC) risk is partly conferred by common, low-penetrance single nucleotide polymorphisms (SNPs). We hypothesized that these SNPs are associated with outcomes in metastatic CRC.<h4>Methods</h4>Six candidate SNPs from 8q24, 10p14, 15q13, 18q21 were investigated for their association with response rate (RR), time to progression (TTP) and overall survival (OS) among 524 patients treated on a phase III clinical trial of first-line chemotherapy for metastatic CRC.<h4>Results</h4>rs10795668 was weakly associated with TTP (p = 0.02), but not RR or OS. No other SNPs carried statistically significant HRs for any of the primary outcomes (RR, TTP or OS).<h4>Conclusion</h4>Common low-penetrance CRC risk SNPs were not associated with outcomes among patients with metastatic CRC. |
| format | Article |
| id | doaj-art-edd25e9487834610ba60cc4912fd4d3e |
| institution | Kabale University |
| issn | 1932-6203 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj-art-edd25e9487834610ba60cc4912fd4d3e2025-08-20T03:44:38ZengPublic Library of Science (PLoS)PLoS ONE1932-62032014-01-0194e9472710.1371/journal.pone.0094727Germline variation in colorectal risk Loci does not influence treatment effect or survival in metastatic colorectal cancer.Hanna K SanoffLindsay A RenfroPradeep PoonnenPratibha AmbadwarDaniel J SargentRichard M GoldbergHoward McLeod<h4>Background</h4>Colorectal cancer (CRC) risk is partly conferred by common, low-penetrance single nucleotide polymorphisms (SNPs). We hypothesized that these SNPs are associated with outcomes in metastatic CRC.<h4>Methods</h4>Six candidate SNPs from 8q24, 10p14, 15q13, 18q21 were investigated for their association with response rate (RR), time to progression (TTP) and overall survival (OS) among 524 patients treated on a phase III clinical trial of first-line chemotherapy for metastatic CRC.<h4>Results</h4>rs10795668 was weakly associated with TTP (p = 0.02), but not RR or OS. No other SNPs carried statistically significant HRs for any of the primary outcomes (RR, TTP or OS).<h4>Conclusion</h4>Common low-penetrance CRC risk SNPs were not associated with outcomes among patients with metastatic CRC.https://doi.org/10.1371/journal.pone.0094727 |
| spellingShingle | Hanna K Sanoff Lindsay A Renfro Pradeep Poonnen Pratibha Ambadwar Daniel J Sargent Richard M Goldberg Howard McLeod Germline variation in colorectal risk Loci does not influence treatment effect or survival in metastatic colorectal cancer. PLoS ONE |
| title | Germline variation in colorectal risk Loci does not influence treatment effect or survival in metastatic colorectal cancer. |
| title_full | Germline variation in colorectal risk Loci does not influence treatment effect or survival in metastatic colorectal cancer. |
| title_fullStr | Germline variation in colorectal risk Loci does not influence treatment effect or survival in metastatic colorectal cancer. |
| title_full_unstemmed | Germline variation in colorectal risk Loci does not influence treatment effect or survival in metastatic colorectal cancer. |
| title_short | Germline variation in colorectal risk Loci does not influence treatment effect or survival in metastatic colorectal cancer. |
| title_sort | germline variation in colorectal risk loci does not influence treatment effect or survival in metastatic colorectal cancer |
| url | https://doi.org/10.1371/journal.pone.0094727 |
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