Germline variation in colorectal risk Loci does not influence treatment effect or survival in metastatic colorectal cancer.
<h4>Background</h4>Colorectal cancer (CRC) risk is partly conferred by common, low-penetrance single nucleotide polymorphisms (SNPs). We hypothesized that these SNPs are associated with outcomes in metastatic CRC.<h4>Methods</h4>Six candidate SNPs from 8q24, 10p14, 15q13, 18q...
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| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2014-01-01
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| Series: | PLoS ONE |
| Online Access: | https://doi.org/10.1371/journal.pone.0094727 |
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| Summary: | <h4>Background</h4>Colorectal cancer (CRC) risk is partly conferred by common, low-penetrance single nucleotide polymorphisms (SNPs). We hypothesized that these SNPs are associated with outcomes in metastatic CRC.<h4>Methods</h4>Six candidate SNPs from 8q24, 10p14, 15q13, 18q21 were investigated for their association with response rate (RR), time to progression (TTP) and overall survival (OS) among 524 patients treated on a phase III clinical trial of first-line chemotherapy for metastatic CRC.<h4>Results</h4>rs10795668 was weakly associated with TTP (p = 0.02), but not RR or OS. No other SNPs carried statistically significant HRs for any of the primary outcomes (RR, TTP or OS).<h4>Conclusion</h4>Common low-penetrance CRC risk SNPs were not associated with outcomes among patients with metastatic CRC. |
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| ISSN: | 1932-6203 |