Advances in Raman spectroscopy for characterising oral cancer and oral potentially malignant disorders
Oral cancer survival rates have seen little improvement over the past few decades. This is mainly due to late detection and a lack of reliable markers to predict disease progression in oral potentially malignant disorders (OPMDs). There is a need for highly specific and sensitive screening tools to...
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| Format: | Article |
| Language: | English |
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Cambridge University Press
2024-01-01
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| Series: | Expert Reviews in Molecular Medicine |
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| Online Access: | https://www.cambridge.org/core/product/identifier/S1462399424000267/type/journal_article |
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| author | Katie Hanna Anna-Lena Asiedu Thomas Theurer David Muirhead Valerie Speirs Yara Oweis Rasha Abu-Eid |
| author_facet | Katie Hanna Anna-Lena Asiedu Thomas Theurer David Muirhead Valerie Speirs Yara Oweis Rasha Abu-Eid |
| author_sort | Katie Hanna |
| collection | DOAJ |
| description | Oral cancer survival rates have seen little improvement over the past few decades. This is mainly due to late detection and a lack of reliable markers to predict disease progression in oral potentially malignant disorders (OPMDs). There is a need for highly specific and sensitive screening tools to enable early detection of malignant transformation. Biochemical alterations to tissues occur as an early response to pathological processes; manifesting as modifications to molecular structure, concentration or conformation. Raman spectroscopy is a powerful analytical technique that can probe these biochemical changes and can be exploited for the generation of novel disease-specific biomarkers. Therefore, Raman spectroscopy has the potential as an adjunct tool that can assist in the early diagnosis of oral cancer and the detection of disease progression in OPMDs. This review describes the use of Raman spectroscopy for the diagnosis of oral cancer and OPMDs based on ex vivo and liquid biopsies as well as in vivo applications that show the potential of this powerful tool to progress from benchtop to chairside. |
| format | Article |
| id | doaj-art-edceaa19a1a446cb9e285bc8f954073a |
| institution | Kabale University |
| issn | 1462-3994 |
| language | English |
| publishDate | 2024-01-01 |
| publisher | Cambridge University Press |
| record_format | Article |
| series | Expert Reviews in Molecular Medicine |
| spelling | doaj-art-edceaa19a1a446cb9e285bc8f954073a2025-08-20T12:57:31ZengCambridge University PressExpert Reviews in Molecular Medicine1462-39942024-01-012610.1017/erm.2024.26Advances in Raman spectroscopy for characterising oral cancer and oral potentially malignant disordersKatie Hanna0https://orcid.org/0000-0001-8348-2399Anna-Lena Asiedu1Thomas Theurer2https://orcid.org/0000-0002-3508-8116David Muirhead3https://orcid.org/0000-0003-2065-6042Valerie Speirs4https://orcid.org/0000-0002-0602-4666Yara Oweis5https://orcid.org/0000-0003-0836-6309Rasha Abu-Eid6https://orcid.org/0000-0002-6634-0329School of Medicine, Medical Sciences and Nutrition, University of Aberdeen, Scotland, UK Aberdeen Cancer Centre, University of Aberdeen, Scotland, UKSchool of Medicine, Medical Sciences and Nutrition, University of Aberdeen, Scotland, UKSchool of Geoscience, University of Aberdeen, Aberdeen, Scotland, UKSchool of Geoscience, University of Aberdeen, Aberdeen, Scotland, UKSchool of Medicine, Medical Sciences and Nutrition, University of Aberdeen, Scotland, UK Aberdeen Cancer Centre, University of Aberdeen, Scotland, UKSchool of Dentistry, University of Jordan, Amman, JordanSchool of Medicine, Medical Sciences and Nutrition, University of Aberdeen, Scotland, UK Aberdeen Cancer Centre, University of Aberdeen, Scotland, UKOral cancer survival rates have seen little improvement over the past few decades. This is mainly due to late detection and a lack of reliable markers to predict disease progression in oral potentially malignant disorders (OPMDs). There is a need for highly specific and sensitive screening tools to enable early detection of malignant transformation. Biochemical alterations to tissues occur as an early response to pathological processes; manifesting as modifications to molecular structure, concentration or conformation. Raman spectroscopy is a powerful analytical technique that can probe these biochemical changes and can be exploited for the generation of novel disease-specific biomarkers. Therefore, Raman spectroscopy has the potential as an adjunct tool that can assist in the early diagnosis of oral cancer and the detection of disease progression in OPMDs. This review describes the use of Raman spectroscopy for the diagnosis of oral cancer and OPMDs based on ex vivo and liquid biopsies as well as in vivo applications that show the potential of this powerful tool to progress from benchtop to chairside.https://www.cambridge.org/core/product/identifier/S1462399424000267/type/journal_articledetectiondiagnosisoral canceroral potentially malignant disordersRaman spectroscopy |
| spellingShingle | Katie Hanna Anna-Lena Asiedu Thomas Theurer David Muirhead Valerie Speirs Yara Oweis Rasha Abu-Eid Advances in Raman spectroscopy for characterising oral cancer and oral potentially malignant disorders Expert Reviews in Molecular Medicine detection diagnosis oral cancer oral potentially malignant disorders Raman spectroscopy |
| title | Advances in Raman spectroscopy for characterising oral cancer and oral potentially malignant disorders |
| title_full | Advances in Raman spectroscopy for characterising oral cancer and oral potentially malignant disorders |
| title_fullStr | Advances in Raman spectroscopy for characterising oral cancer and oral potentially malignant disorders |
| title_full_unstemmed | Advances in Raman spectroscopy for characterising oral cancer and oral potentially malignant disorders |
| title_short | Advances in Raman spectroscopy for characterising oral cancer and oral potentially malignant disorders |
| title_sort | advances in raman spectroscopy for characterising oral cancer and oral potentially malignant disorders |
| topic | detection diagnosis oral cancer oral potentially malignant disorders Raman spectroscopy |
| url | https://www.cambridge.org/core/product/identifier/S1462399424000267/type/journal_article |
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