Repeatability of artificial gravity tolerance times
IntroductionExposure to microgravity results in physiological deconditioning, including orthostatic intolerance. Artificial gravity (AG) from short-arm centrifuges is being tested in ground-based studies to counter these effects. Orthostatic tolerance testing with centrifuges before and after these...
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Frontiers Media S.A.
2025-05-01
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| Series: | Frontiers in Physiology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphys.2025.1464028/full |
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| author | T. Stead A. P. Blaber A. P. Blaber D. N. Divsalar D. Xu K. Tavakolian K. Tavakolian J. Evans R. Billette de Villemeur M-P Bareille A. Saloň B. Steuber N. Goswami N. Goswami N. Goswami |
| author_facet | T. Stead A. P. Blaber A. P. Blaber D. N. Divsalar D. Xu K. Tavakolian K. Tavakolian J. Evans R. Billette de Villemeur M-P Bareille A. Saloň B. Steuber N. Goswami N. Goswami N. Goswami |
| author_sort | T. Stead |
| collection | DOAJ |
| description | IntroductionExposure to microgravity results in physiological deconditioning, including orthostatic intolerance. Artificial gravity (AG) from short-arm centrifuges is being tested in ground-based studies to counter these effects. Orthostatic tolerance testing with centrifuges before and after these spaceflight analogs could determine the efficacy of an AG countermeasure to orthostatic tolerance. However, there has not been an investigation on how long before analog testing AG orthostatic tolerance data would remain valid for such a study.MethodsA secondary analysis of two experiments involving AG orthostatic tolerance testing (starting at 0.6 for females and 0.8 Gz for males and increased by 0.1 Gz every 3 minutes until presyncope) conducted 7 months apart at MEDES revealed 4 male and 3 female participants who had taken part in both.ResultsComparisons of participants’ time to presyncope between the two tests using Lin’s concordance correlation coefficient (LCCC) showed a significant relationship in time to presyncope between the two test dates (LCCC = 0.98) for males but not for females (LCCC = −0.64). While the cardiovascular data from one female was unusable, the mean heart rate responses to increasing artificial gravity during the orthostatic tolerance procedure showed a strong linear correlation between the two tests for all other participants (all p < 0.008). The LCCC heart rate changes with centrifuge level varied across male participants from 0.61 to 0.97, suggesting that the high LCCC for time to presyncope was achieved with varied HR baselines between the two test dates.DiscussionThese findings indicate that time-to-presyncope tests may remain valid up to 7 months after the testing date for males. We highly recommend further study with larger numbers of male and female participants. |
| format | Article |
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| institution | Kabale University |
| issn | 1664-042X |
| language | English |
| publishDate | 2025-05-01 |
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| spelling | doaj-art-edcbe651176a46d7a2ffaaa89e92717d2025-08-20T03:52:07ZengFrontiers Media S.A.Frontiers in Physiology1664-042X2025-05-011610.3389/fphys.2025.14640281464028Repeatability of artificial gravity tolerance timesT. Stead0A. P. Blaber1A. P. Blaber2D. N. Divsalar3D. Xu4K. Tavakolian5K. Tavakolian6J. Evans7R. Billette de Villemeur8M-P Bareille9A. Saloň10B. Steuber11N. Goswami12N. Goswami13N. Goswami14Department of Biomedical Physiology and Kinesiology, Simon Fraser University, Burnaby, BC, CanadaDepartment of Biomedical Physiology and Kinesiology, Simon Fraser University, Burnaby, BC, CanadaBiomedical Engineering Program, University of North Dakota, Grand Forks, ND, United StatesDepartment of Biomedical Physiology and Kinesiology, Simon Fraser University, Burnaby, BC, CanadaDepartment of Biomedical Physiology and Kinesiology, Simon Fraser University, Burnaby, BC, CanadaDepartment of Biomedical Physiology and Kinesiology, Simon Fraser University, Burnaby, BC, CanadaBiomedical Engineering Program, University of North Dakota, Grand Forks, ND, United StatesBiomedical Engineering, Retired, University of Kentucky, Lexington, KY, United StatesInstitut de Médecine et de Physiologie Spatiales, Toulouse, FranceInstitut de Médecine et de Physiologie Spatiales, Toulouse, FranceGravitational Physiology and Aging Research Unit, Division of Physiology and Pathophysiology, Otto Löwi Research Center of Vascular Biology, Immunity and Inflammation, Medical University of Graz, Graz, AustriaGravitational Physiology and Aging Research Unit, Division of Physiology and Pathophysiology, Otto Löwi Research Center of Vascular Biology, Immunity and Inflammation, Medical University of Graz, Graz, AustriaGravitational Physiology and Aging Research Unit, Division of Physiology and Pathophysiology, Otto Löwi Research Center of Vascular Biology, Immunity and Inflammation, Medical University of Graz, Graz, AustriaCenter for Space and Aviation Health, Mohammed Bin Rashid University of Medicine and Health Sciences, Dubai, United Arab EmiratesHealth Sciences Division, Innlandet University College, Innlandet, NorwayIntroductionExposure to microgravity results in physiological deconditioning, including orthostatic intolerance. Artificial gravity (AG) from short-arm centrifuges is being tested in ground-based studies to counter these effects. Orthostatic tolerance testing with centrifuges before and after these spaceflight analogs could determine the efficacy of an AG countermeasure to orthostatic tolerance. However, there has not been an investigation on how long before analog testing AG orthostatic tolerance data would remain valid for such a study.MethodsA secondary analysis of two experiments involving AG orthostatic tolerance testing (starting at 0.6 for females and 0.8 Gz for males and increased by 0.1 Gz every 3 minutes until presyncope) conducted 7 months apart at MEDES revealed 4 male and 3 female participants who had taken part in both.ResultsComparisons of participants’ time to presyncope between the two tests using Lin’s concordance correlation coefficient (LCCC) showed a significant relationship in time to presyncope between the two test dates (LCCC = 0.98) for males but not for females (LCCC = −0.64). While the cardiovascular data from one female was unusable, the mean heart rate responses to increasing artificial gravity during the orthostatic tolerance procedure showed a strong linear correlation between the two tests for all other participants (all p < 0.008). The LCCC heart rate changes with centrifuge level varied across male participants from 0.61 to 0.97, suggesting that the high LCCC for time to presyncope was achieved with varied HR baselines between the two test dates.DiscussionThese findings indicate that time-to-presyncope tests may remain valid up to 7 months after the testing date for males. We highly recommend further study with larger numbers of male and female participants.https://www.frontiersin.org/articles/10.3389/fphys.2025.1464028/fullshort-arm human centrifugepresyncopecardiovascularheart rateblood pressure |
| spellingShingle | T. Stead A. P. Blaber A. P. Blaber D. N. Divsalar D. Xu K. Tavakolian K. Tavakolian J. Evans R. Billette de Villemeur M-P Bareille A. Saloň B. Steuber N. Goswami N. Goswami N. Goswami Repeatability of artificial gravity tolerance times Frontiers in Physiology short-arm human centrifuge presyncope cardiovascular heart rate blood pressure |
| title | Repeatability of artificial gravity tolerance times |
| title_full | Repeatability of artificial gravity tolerance times |
| title_fullStr | Repeatability of artificial gravity tolerance times |
| title_full_unstemmed | Repeatability of artificial gravity tolerance times |
| title_short | Repeatability of artificial gravity tolerance times |
| title_sort | repeatability of artificial gravity tolerance times |
| topic | short-arm human centrifuge presyncope cardiovascular heart rate blood pressure |
| url | https://www.frontiersin.org/articles/10.3389/fphys.2025.1464028/full |
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