Association between social determinants of health and premature atherosclerotic cardiovascular disease and sex differences in US adults: A cross-sectional study
Background: Premature atherosclerotic cardiovascular disease (ASCVD) is a major public health issue, leading to productivity losses and higher healthcare costs. This study examines the association between social determinants of health (SDoH) and premature ASCVD, with a focus on sex differences. Meth...
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| Language: | English |
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Elsevier
2025-02-01
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| Series: | Preventive Medicine Reports |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2211335525000063 |
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| author | Chun Yang Na Zhang Tiankuo Gao Yingxin Zhu Chen Gong Mingyue Xu Cuicui Feng |
| author_facet | Chun Yang Na Zhang Tiankuo Gao Yingxin Zhu Chen Gong Mingyue Xu Cuicui Feng |
| author_sort | Chun Yang |
| collection | DOAJ |
| description | Background: Premature atherosclerotic cardiovascular disease (ASCVD) is a major public health issue, leading to productivity losses and higher healthcare costs. This study examines the association between social determinants of health (SDoH) and premature ASCVD, with a focus on sex differences. Method: Data on self-reported SDoH based on Healthy People 2030 criteria were obtained from U.S. National Health and Nutrition Examination Surveys (2003–2018). Weighted logistic regression models were used to examine the relationship between SDoH (including eight sub-items and the cumulative number of unfavorable SDoH) and premature ASCVD. Analyses were further stratified by sex. Result: A total of 40,536 participants aged ≥18 years (19,548 men and 20,888 women) were included in the analysis. The overall prevalence of premature ASCVD was 1756 cases, with a weighted estimate of 7,625,240. Although women had a lower prevalence of premature ASCVD (3.2 % [n = 784] vs. 4.3 % [n = 972]), they exhibited a higher level of unfavorable SDoH compared to men. Logistic regression indicated a 21 % increase in risk for each additional unfavorable SDoH (AOR = 1.21; 95 % CI, 1.16–1.26), and the cumulative number of unfavorable SDoH were positively associated with the odds of developing premature ASCVD (P for trend <0.01). Notably, the impact of unfavorable SDoH was greater in women, revealing significant sex disparities in susceptibility to premature ASCVD. Conclusion: This study demonstrates that unfavorable SDoH significantly increase the risk of developing premature ASCVD. Furthermore, the cumulative effect of unfavorable SDoH pose a higher risk for women. |
| format | Article |
| id | doaj-art-edc7d9918dae4a81a06e267ac7b795ca |
| institution | Kabale University |
| issn | 2211-3355 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Preventive Medicine Reports |
| spelling | doaj-art-edc7d9918dae4a81a06e267ac7b795ca2025-02-08T05:00:13ZengElsevierPreventive Medicine Reports2211-33552025-02-0150102967Association between social determinants of health and premature atherosclerotic cardiovascular disease and sex differences in US adults: A cross-sectional studyChun Yang0Na Zhang1Tiankuo Gao2Yingxin Zhu3Chen Gong4Mingyue Xu5Cuicui Feng6Beijing Anzhen hospital, Capital Medical University, Beijing 100029, ChinaBeijing Friendship Hospital, Capital Medical University, Beijing 100053, ChinaBeijing Anzhen hospital, Capital Medical University, Beijing 100029, ChinaBeijing Anzhen hospital, Capital Medical University, Beijing 100029, ChinaBeijing Anzhen hospital, Capital Medical University, Beijing 100029, ChinaBeijing Friendship Hospital, Capital Medical University, Beijing 100053, ChinaBeijing Anzhen hospital, Capital Medical University, Beijing 100029, China; Corresponding author.Background: Premature atherosclerotic cardiovascular disease (ASCVD) is a major public health issue, leading to productivity losses and higher healthcare costs. This study examines the association between social determinants of health (SDoH) and premature ASCVD, with a focus on sex differences. Method: Data on self-reported SDoH based on Healthy People 2030 criteria were obtained from U.S. National Health and Nutrition Examination Surveys (2003–2018). Weighted logistic regression models were used to examine the relationship between SDoH (including eight sub-items and the cumulative number of unfavorable SDoH) and premature ASCVD. Analyses were further stratified by sex. Result: A total of 40,536 participants aged ≥18 years (19,548 men and 20,888 women) were included in the analysis. The overall prevalence of premature ASCVD was 1756 cases, with a weighted estimate of 7,625,240. Although women had a lower prevalence of premature ASCVD (3.2 % [n = 784] vs. 4.3 % [n = 972]), they exhibited a higher level of unfavorable SDoH compared to men. Logistic regression indicated a 21 % increase in risk for each additional unfavorable SDoH (AOR = 1.21; 95 % CI, 1.16–1.26), and the cumulative number of unfavorable SDoH were positively associated with the odds of developing premature ASCVD (P for trend <0.01). Notably, the impact of unfavorable SDoH was greater in women, revealing significant sex disparities in susceptibility to premature ASCVD. Conclusion: This study demonstrates that unfavorable SDoH significantly increase the risk of developing premature ASCVD. Furthermore, the cumulative effect of unfavorable SDoH pose a higher risk for women.http://www.sciencedirect.com/science/article/pii/S2211335525000063Atherosclerotic cardiovascular diseasePrematureSex differencesSocial determinants of healthNational Health and nutrition examination surveys |
| spellingShingle | Chun Yang Na Zhang Tiankuo Gao Yingxin Zhu Chen Gong Mingyue Xu Cuicui Feng Association between social determinants of health and premature atherosclerotic cardiovascular disease and sex differences in US adults: A cross-sectional study Preventive Medicine Reports Atherosclerotic cardiovascular disease Premature Sex differences Social determinants of health National Health and nutrition examination surveys |
| title | Association between social determinants of health and premature atherosclerotic cardiovascular disease and sex differences in US adults: A cross-sectional study |
| title_full | Association between social determinants of health and premature atherosclerotic cardiovascular disease and sex differences in US adults: A cross-sectional study |
| title_fullStr | Association between social determinants of health and premature atherosclerotic cardiovascular disease and sex differences in US adults: A cross-sectional study |
| title_full_unstemmed | Association between social determinants of health and premature atherosclerotic cardiovascular disease and sex differences in US adults: A cross-sectional study |
| title_short | Association between social determinants of health and premature atherosclerotic cardiovascular disease and sex differences in US adults: A cross-sectional study |
| title_sort | association between social determinants of health and premature atherosclerotic cardiovascular disease and sex differences in us adults a cross sectional study |
| topic | Atherosclerotic cardiovascular disease Premature Sex differences Social determinants of health National Health and nutrition examination surveys |
| url | http://www.sciencedirect.com/science/article/pii/S2211335525000063 |
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