Diagnostic Efficacy of Bone SPECT Techniques in Differentiating Unilateral and Bilateral Condylar Hyperplasia
<b>Objectives:</b> This analytical cross-sectional study evaluates diagnostic approaches for active condylar hyperplasia using bone SPECT techniques. <b>Methods</b>: it was compared the effectiveness of relative activity assessments between condyles and quantitative analysis...
Saved in:
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2024-11-01
|
| Series: | Diagnostics |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2075-4418/14/22/2548 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850267481905561600 |
|---|---|
| author | Luz Kelly Anzola Natalia Venegas Maria Clara Jaramillo Sergio Moreno Mauricio Hinojosa Enrique Amador Martin Orozco Fernando Mut |
| author_facet | Luz Kelly Anzola Natalia Venegas Maria Clara Jaramillo Sergio Moreno Mauricio Hinojosa Enrique Amador Martin Orozco Fernando Mut |
| author_sort | Luz Kelly Anzola |
| collection | DOAJ |
| description | <b>Objectives:</b> This analytical cross-sectional study evaluates diagnostic approaches for active condylar hyperplasia using bone SPECT techniques. <b>Methods</b>: it was compared the effectiveness of relative activity assessments between condyles and quantitative analysis using the condyle/clivus ratio. <b>Results</b>: This study’s findings reveal that the condyle/clivus ratio method significantly outperforms the relative uptake method, achieving a sensitivity of 90.1% (95% CI: 84.1–94) compared to 40.7% (95% CI: 33.5–48.2), and a specificity of 77.1% (95% CI: 67.4–85) versus 72.9% (95% CI: 62.9–81.5). The condyle/clivus ratio also showed a more favorable negative likelihood ratio of 0.13 compared to 0.82 for relative uptake, and a higher area under the curve (AUC) of 0.8360 versus 0.5679. Statistically significant differences were noted (<i>p</i> = 0.0001). The condyle/clivus ratio method effectively identifies affected condyles in unilateral and bilateral condylar hyperplasia cases. <b>Conclusions:</b> This study emphasizes the importance of incorporating comprehensive clinical evaluations and imaging modalities for assessing condylar growth activity, underscoring the need for tailored reference values in different populations to ensure reliable diagnostic interpretations. |
| format | Article |
| id | doaj-art-edbb0d9b8ee2403a98c789c249bfd180 |
| institution | OA Journals |
| issn | 2075-4418 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Diagnostics |
| spelling | doaj-art-edbb0d9b8ee2403a98c789c249bfd1802025-08-20T01:53:45ZengMDPI AGDiagnostics2075-44182024-11-011422254810.3390/diagnostics14222548Diagnostic Efficacy of Bone SPECT Techniques in Differentiating Unilateral and Bilateral Condylar HyperplasiaLuz Kelly Anzola0Natalia Venegas1Maria Clara Jaramillo2Sergio Moreno3Mauricio Hinojosa4Enrique Amador5Martin Orozco6Fernando Mut7Nuclear Medicine Unit, Clinica Reina Sofia, Bogota 110131, ColombiaNuclear Medicine Postgraduate Program, Fundación Universitaria Sanitas, Bogota 110931, ColombiaMaxillofacial Surgery Clinica Reina Sofia, Bogota 110131, ColombiaClinical Epidemiologist, Universidad Nacional de Colombia, Bogota 111311, ColombiaMedicina Nuclear Sanitas Palermo, Bogota 111311, ColombiaMaxillofacial Surgery Clinica Reina Sofia, Bogota 110131, ColombiaMaxillofacial Department, Clinica Universitaria Colombia, Bogota 110911, ColombiaNuclear Medicine Unit, Hospital Italiano, Montevideo 11600, Uruguay<b>Objectives:</b> This analytical cross-sectional study evaluates diagnostic approaches for active condylar hyperplasia using bone SPECT techniques. <b>Methods</b>: it was compared the effectiveness of relative activity assessments between condyles and quantitative analysis using the condyle/clivus ratio. <b>Results</b>: This study’s findings reveal that the condyle/clivus ratio method significantly outperforms the relative uptake method, achieving a sensitivity of 90.1% (95% CI: 84.1–94) compared to 40.7% (95% CI: 33.5–48.2), and a specificity of 77.1% (95% CI: 67.4–85) versus 72.9% (95% CI: 62.9–81.5). The condyle/clivus ratio also showed a more favorable negative likelihood ratio of 0.13 compared to 0.82 for relative uptake, and a higher area under the curve (AUC) of 0.8360 versus 0.5679. Statistically significant differences were noted (<i>p</i> = 0.0001). The condyle/clivus ratio method effectively identifies affected condyles in unilateral and bilateral condylar hyperplasia cases. <b>Conclusions:</b> This study emphasizes the importance of incorporating comprehensive clinical evaluations and imaging modalities for assessing condylar growth activity, underscoring the need for tailored reference values in different populations to ensure reliable diagnostic interpretations.https://www.mdpi.com/2075-4418/14/22/2548mandibular condyletemporomandibular jointsingle-photon emission computed tomographyscintigraphyradioisotope diagnostic |
| spellingShingle | Luz Kelly Anzola Natalia Venegas Maria Clara Jaramillo Sergio Moreno Mauricio Hinojosa Enrique Amador Martin Orozco Fernando Mut Diagnostic Efficacy of Bone SPECT Techniques in Differentiating Unilateral and Bilateral Condylar Hyperplasia Diagnostics mandibular condyle temporomandibular joint single-photon emission computed tomography scintigraphy radioisotope diagnostic |
| title | Diagnostic Efficacy of Bone SPECT Techniques in Differentiating Unilateral and Bilateral Condylar Hyperplasia |
| title_full | Diagnostic Efficacy of Bone SPECT Techniques in Differentiating Unilateral and Bilateral Condylar Hyperplasia |
| title_fullStr | Diagnostic Efficacy of Bone SPECT Techniques in Differentiating Unilateral and Bilateral Condylar Hyperplasia |
| title_full_unstemmed | Diagnostic Efficacy of Bone SPECT Techniques in Differentiating Unilateral and Bilateral Condylar Hyperplasia |
| title_short | Diagnostic Efficacy of Bone SPECT Techniques in Differentiating Unilateral and Bilateral Condylar Hyperplasia |
| title_sort | diagnostic efficacy of bone spect techniques in differentiating unilateral and bilateral condylar hyperplasia |
| topic | mandibular condyle temporomandibular joint single-photon emission computed tomography scintigraphy radioisotope diagnostic |
| url | https://www.mdpi.com/2075-4418/14/22/2548 |
| work_keys_str_mv | AT luzkellyanzola diagnosticefficacyofbonespecttechniquesindifferentiatingunilateralandbilateralcondylarhyperplasia AT nataliavenegas diagnosticefficacyofbonespecttechniquesindifferentiatingunilateralandbilateralcondylarhyperplasia AT mariaclarajaramillo diagnosticefficacyofbonespecttechniquesindifferentiatingunilateralandbilateralcondylarhyperplasia AT sergiomoreno diagnosticefficacyofbonespecttechniquesindifferentiatingunilateralandbilateralcondylarhyperplasia AT mauriciohinojosa diagnosticefficacyofbonespecttechniquesindifferentiatingunilateralandbilateralcondylarhyperplasia AT enriqueamador diagnosticefficacyofbonespecttechniquesindifferentiatingunilateralandbilateralcondylarhyperplasia AT martinorozco diagnosticefficacyofbonespecttechniquesindifferentiatingunilateralandbilateralcondylarhyperplasia AT fernandomut diagnosticefficacyofbonespecttechniquesindifferentiatingunilateralandbilateralcondylarhyperplasia |