Plasma levels of C-reactive protein and Interleukin-6 as markers of inflammation in patients with operative treated fractures
Conditions that affect plasma concentrations of acute-phase proteins include infections, trauma, surgical treatment, burns, tissue ischemia (infarctions), various immunological inflammatory conditions and cancer. The cytokine Interleukin-6 (IL-6) is the main stimulator for the production of numero...
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University Ss Cyril and Methodius in Skopje, Faculty of Pharmacy and Macedonian Pharmaceutical Association
2024-10-01
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| Series: | Makedonsko Farmacevtski Bilten |
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| Online Access: | https://bulletin.mfd.org.mk/volumes/Volume%2070_1/70_1_002.pdf |
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| _version_ | 1850193642175594496 |
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| author | Hristijan Kostov Elena Kostova |
| author_facet | Hristijan Kostov Elena Kostova |
| author_sort | Hristijan Kostov |
| collection | DOAJ |
| description | Conditions that affect plasma concentrations of acute-phase proteins include infections, trauma, surgical treatment, burns, tissue
ischemia (infarctions), various immunological inflammatory conditions and cancer. The cytokine Interleukin-6 (IL-6) is the main stimulator
for the production of numerous acute-phase proteins. It has been established that the induction of C-reactive protein (CRP) and production
of serum amyloid A is caused by the cytokines IL-6 and IL-1 or TNF-alpha. Elevated levels of IL-6 during acute injuries or stress are often
used as an indicator of systemic inflammation and are predictors of preoperative morbidity.
We undertook this prospective randomized study in 90 patients undergoing surgery procedure after high-energy trauma, low-energy
trauma and open fracture to define plasma levels of IL-6 and CRP over a 2-week period. We presented our results at seven time points,
namely 6 hours pre-operatively and post-operatively in 2, 4, 5, 7 and 14 days respectively. We have attempted to find out whether IL-6 and
CRP levels returned to baseline during this study period.
In our study, we determined the influence of the examined parameters CRP and IL-6 in plasma on the early detection of surgical
postoperative inflammation in operatively treated fractures. With the obtained results of our examined parameters, we can state that is
provided a place for the routine procedure of CRP and IL-6 as predictors of possible postoperative inflammation. |
| format | Article |
| id | doaj-art-edba2333fec1444aba19f1c1f676f4e9 |
| institution | OA Journals |
| issn | 1857-8969 |
| language | English |
| publishDate | 2024-10-01 |
| publisher | University Ss Cyril and Methodius in Skopje, Faculty of Pharmacy and Macedonian Pharmaceutical Association |
| record_format | Article |
| series | Makedonsko Farmacevtski Bilten |
| spelling | doaj-art-edba2333fec1444aba19f1c1f676f4e92025-08-20T02:14:14ZengUniversity Ss Cyril and Methodius in Skopje, Faculty of Pharmacy and Macedonian Pharmaceutical AssociationMakedonsko Farmacevtski Bilten1857-89692024-10-0170131110.33320/maced.pharm.bull.2024.70.01.001Plasma levels of C-reactive protein and Interleukin-6 as markers of inflammation in patients with operative treated fracturesHristijan Kostov0Elena Kostova1University Clinic for Traumatology, Orthopedics, Anesthesia, Reanimation, and Intensive Care and Emergency Medicine, 50th Divizija, 1000 Skopje, Republic of North MacedoniaDepartment of Preclinical and Clinical Pharmacology with Toxicology, Faculty of Medicine, Ss. Cyril and Methodius University, 50th Divizja, 1000 Skopje, Republic of North MacedoniaConditions that affect plasma concentrations of acute-phase proteins include infections, trauma, surgical treatment, burns, tissue ischemia (infarctions), various immunological inflammatory conditions and cancer. The cytokine Interleukin-6 (IL-6) is the main stimulator for the production of numerous acute-phase proteins. It has been established that the induction of C-reactive protein (CRP) and production of serum amyloid A is caused by the cytokines IL-6 and IL-1 or TNF-alpha. Elevated levels of IL-6 during acute injuries or stress are often used as an indicator of systemic inflammation and are predictors of preoperative morbidity. We undertook this prospective randomized study in 90 patients undergoing surgery procedure after high-energy trauma, low-energy trauma and open fracture to define plasma levels of IL-6 and CRP over a 2-week period. We presented our results at seven time points, namely 6 hours pre-operatively and post-operatively in 2, 4, 5, 7 and 14 days respectively. We have attempted to find out whether IL-6 and CRP levels returned to baseline during this study period. In our study, we determined the influence of the examined parameters CRP and IL-6 in plasma on the early detection of surgical postoperative inflammation in operatively treated fractures. With the obtained results of our examined parameters, we can state that is provided a place for the routine procedure of CRP and IL-6 as predictors of possible postoperative inflammation.https://bulletin.mfd.org.mk/volumes/Volume%2070_1/70_1_002.pdfc-reactive proteininterleukin-6plasmatraumainflammaation |
| spellingShingle | Hristijan Kostov Elena Kostova Plasma levels of C-reactive protein and Interleukin-6 as markers of inflammation in patients with operative treated fractures Makedonsko Farmacevtski Bilten c-reactive protein interleukin-6 plasma trauma inflammaation |
| title | Plasma levels of C-reactive protein and Interleukin-6 as markers of inflammation in patients with operative treated fractures |
| title_full | Plasma levels of C-reactive protein and Interleukin-6 as markers of inflammation in patients with operative treated fractures |
| title_fullStr | Plasma levels of C-reactive protein and Interleukin-6 as markers of inflammation in patients with operative treated fractures |
| title_full_unstemmed | Plasma levels of C-reactive protein and Interleukin-6 as markers of inflammation in patients with operative treated fractures |
| title_short | Plasma levels of C-reactive protein and Interleukin-6 as markers of inflammation in patients with operative treated fractures |
| title_sort | plasma levels of c reactive protein and interleukin 6 as markers of inflammation in patients with operative treated fractures |
| topic | c-reactive protein interleukin-6 plasma trauma inflammaation |
| url | https://bulletin.mfd.org.mk/volumes/Volume%2070_1/70_1_002.pdf |
| work_keys_str_mv | AT hristijankostov plasmalevelsofcreactiveproteinandinterleukin6asmarkersofinflammationinpatientswithoperativetreatedfractures AT elenakostova plasmalevelsofcreactiveproteinandinterleukin6asmarkersofinflammationinpatientswithoperativetreatedfractures |