Synthesis and study of complexes of the novel Russian antiviral drug Camphecene with Plant’s Flavonoids
Traditionally, glycyrrhizic acid has been used to form polydentate complexes. For the first time in the presented paper, the complexation of the Plant’s Flavonoids (Quercetin (Qu) and its glycoside - Rutin (Rut)) with the novel Russian antiviral drug Camphecene (Camph) was investigated. The complexe...
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| Language: | English |
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Ural Federal University
2021-04-01
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| Series: | Chimica Techno Acta |
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| Online Access: | https://chimicatechnoacta.ru/article/view/4978 |
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| author | S. S. Khizrieva E. V. Vetrova S. N. Borisenko E. V. Maksimenko N. I. Borisenko |
| author_facet | S. S. Khizrieva E. V. Vetrova S. N. Borisenko E. V. Maksimenko N. I. Borisenko |
| author_sort | S. S. Khizrieva |
| collection | DOAJ |
| description | Traditionally, glycyrrhizic acid has been used to form polydentate complexes. For the first time in the presented paper, the complexation of the Plant’s Flavonoids (Quercetin (Qu) and its glycoside - Rutin (Rut)) with the novel Russian antiviral drug Camphecene (Camph) was investigated. The complexes obtained at different molar ratios were studied using UV/Vis spectroscopy. Formation of the host: guest complexes were registered: Qu and Rut molecular complexes (Camph+2Qu; Camph+2Rut) with a stability constant K = 3.3·108 M-2. Comparison of the binding constants of the obtained complexes shows that the efficiency of Camphecene complexation with the participation of flavonoids is more efficient than with the participation of triterpenoids. Besides, it was found that the complexes of Camphecene with the quercetin and rutin are soluble in water, in contrast to the complexes with triterpenoids, which makes it possible to increase the bioavailability of both Camphecene and flavonoids. The obtained results demonstrate the high potential of flavonoids Qu and Rut to the development of novel pharmaceutical forms using the example of Camphecene in the form of molecular complexes, as the novel forms of delivery. |
| format | Article |
| id | doaj-art-edb8f0c46cc64c2ba49378fa127cefbb |
| institution | DOAJ |
| issn | 2411-1414 |
| language | English |
| publishDate | 2021-04-01 |
| publisher | Ural Federal University |
| record_format | Article |
| series | Chimica Techno Acta |
| spelling | doaj-art-edb8f0c46cc64c2ba49378fa127cefbb2025-08-20T03:20:43ZengUral Federal UniversityChimica Techno Acta2411-14142021-04-018210.15826/chimtech.2021.8.2.023911Synthesis and study of complexes of the novel Russian antiviral drug Camphecene with Plant’s FlavonoidsS. S. Khizrieva0E. V. Vetrova1S. N. Borisenko2E. V. Maksimenko3N. I. Borisenko4Southern Federal University, Rostov-on-DonSouthern Federal University, Rostov-on-DonSouthern Federal University, Rostov-on-DonSouthern Federal University, Rostov-on-DonSouthern Federal University, Rostov-on-DonTraditionally, glycyrrhizic acid has been used to form polydentate complexes. For the first time in the presented paper, the complexation of the Plant’s Flavonoids (Quercetin (Qu) and its glycoside - Rutin (Rut)) with the novel Russian antiviral drug Camphecene (Camph) was investigated. The complexes obtained at different molar ratios were studied using UV/Vis spectroscopy. Formation of the host: guest complexes were registered: Qu and Rut molecular complexes (Camph+2Qu; Camph+2Rut) with a stability constant K = 3.3·108 M-2. Comparison of the binding constants of the obtained complexes shows that the efficiency of Camphecene complexation with the participation of flavonoids is more efficient than with the participation of triterpenoids. Besides, it was found that the complexes of Camphecene with the quercetin and rutin are soluble in water, in contrast to the complexes with triterpenoids, which makes it possible to increase the bioavailability of both Camphecene and flavonoids. The obtained results demonstrate the high potential of flavonoids Qu and Rut to the development of novel pharmaceutical forms using the example of Camphecene in the form of molecular complexes, as the novel forms of delivery.https://chimicatechnoacta.ru/article/view/4978camphecenequercetinrutinantiviral activitysupramolecular complexes |
| spellingShingle | S. S. Khizrieva E. V. Vetrova S. N. Borisenko E. V. Maksimenko N. I. Borisenko Synthesis and study of complexes of the novel Russian antiviral drug Camphecene with Plant’s Flavonoids Chimica Techno Acta camphecene quercetin rutin antiviral activity supramolecular complexes |
| title | Synthesis and study of complexes of the novel Russian antiviral drug Camphecene with Plant’s Flavonoids |
| title_full | Synthesis and study of complexes of the novel Russian antiviral drug Camphecene with Plant’s Flavonoids |
| title_fullStr | Synthesis and study of complexes of the novel Russian antiviral drug Camphecene with Plant’s Flavonoids |
| title_full_unstemmed | Synthesis and study of complexes of the novel Russian antiviral drug Camphecene with Plant’s Flavonoids |
| title_short | Synthesis and study of complexes of the novel Russian antiviral drug Camphecene with Plant’s Flavonoids |
| title_sort | synthesis and study of complexes of the novel russian antiviral drug camphecene with plant s flavonoids |
| topic | camphecene quercetin rutin antiviral activity supramolecular complexes |
| url | https://chimicatechnoacta.ru/article/view/4978 |
| work_keys_str_mv | AT sskhizrieva synthesisandstudyofcomplexesofthenovelrussianantiviraldrugcamphecenewithplantsflavonoids AT evvetrova synthesisandstudyofcomplexesofthenovelrussianantiviraldrugcamphecenewithplantsflavonoids AT snborisenko synthesisandstudyofcomplexesofthenovelrussianantiviraldrugcamphecenewithplantsflavonoids AT evmaksimenko synthesisandstudyofcomplexesofthenovelrussianantiviraldrugcamphecenewithplantsflavonoids AT niborisenko synthesisandstudyofcomplexesofthenovelrussianantiviraldrugcamphecenewithplantsflavonoids |