Hypercalcemia, Acute Kidney Injury, and Metabolic Alkalosis
Calcium regulation is tightly controlled in the body. Multiple causes of hypercalcemia have been studied including primary hyperparathyroidism, hypercalcemia of malignancy, and chronic granulomatous disorders. Among the less studied causes is calcium-alkali syndrome. Here, we discuss a case of hyper...
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| Format: | Article |
| Language: | English |
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Wiley
2022-01-01
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| Series: | Case Reports in Nephrology |
| Online Access: | http://dx.doi.org/10.1155/2022/1320259 |
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| _version_ | 1832545959360331776 |
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| author | Faten Aqeel Jennifer Del Castillo Bernard G. Jaar Mohamad Hanouneh |
| author_facet | Faten Aqeel Jennifer Del Castillo Bernard G. Jaar Mohamad Hanouneh |
| author_sort | Faten Aqeel |
| collection | DOAJ |
| description | Calcium regulation is tightly controlled in the body. Multiple causes of hypercalcemia have been studied including primary hyperparathyroidism, hypercalcemia of malignancy, and chronic granulomatous disorders. Among the less studied causes is calcium-alkali syndrome. Here, we discuss a case of hypercalcemia secondary to calcium-alkali syndrome, presenting with hypercalcemia, metabolic alkalosis, and acute kidney injury as a result of ingestion of a large amount of calcium supplements. Hypercalcemia can result in impaired collecting duct system sensitivity to antidiuretic hormone, afferent arteriole constriction, and activation of calcium sensor receptors in multiple tissues. The net effect is an increase in calcium reabsorption with a salt and water diuresis which leads to volume depletion, acute kidney injury, and metabolic alkalosis. |
| format | Article |
| id | doaj-art-edb8902fad994db8959422c3f21fcfcb |
| institution | Kabale University |
| issn | 2090-665X |
| language | English |
| publishDate | 2022-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Nephrology |
| spelling | doaj-art-edb8902fad994db8959422c3f21fcfcb2025-02-03T07:24:17ZengWileyCase Reports in Nephrology2090-665X2022-01-01202210.1155/2022/1320259Hypercalcemia, Acute Kidney Injury, and Metabolic AlkalosisFaten Aqeel0Jennifer Del Castillo1Bernard G. Jaar2Mohamad Hanouneh3Johns Hopkins University School of MedicineDepartment of Internal MedicineJohns Hopkins University School of MedicineJohns Hopkins University School of MedicineCalcium regulation is tightly controlled in the body. Multiple causes of hypercalcemia have been studied including primary hyperparathyroidism, hypercalcemia of malignancy, and chronic granulomatous disorders. Among the less studied causes is calcium-alkali syndrome. Here, we discuss a case of hypercalcemia secondary to calcium-alkali syndrome, presenting with hypercalcemia, metabolic alkalosis, and acute kidney injury as a result of ingestion of a large amount of calcium supplements. Hypercalcemia can result in impaired collecting duct system sensitivity to antidiuretic hormone, afferent arteriole constriction, and activation of calcium sensor receptors in multiple tissues. The net effect is an increase in calcium reabsorption with a salt and water diuresis which leads to volume depletion, acute kidney injury, and metabolic alkalosis.http://dx.doi.org/10.1155/2022/1320259 |
| spellingShingle | Faten Aqeel Jennifer Del Castillo Bernard G. Jaar Mohamad Hanouneh Hypercalcemia, Acute Kidney Injury, and Metabolic Alkalosis Case Reports in Nephrology |
| title | Hypercalcemia, Acute Kidney Injury, and Metabolic Alkalosis |
| title_full | Hypercalcemia, Acute Kidney Injury, and Metabolic Alkalosis |
| title_fullStr | Hypercalcemia, Acute Kidney Injury, and Metabolic Alkalosis |
| title_full_unstemmed | Hypercalcemia, Acute Kidney Injury, and Metabolic Alkalosis |
| title_short | Hypercalcemia, Acute Kidney Injury, and Metabolic Alkalosis |
| title_sort | hypercalcemia acute kidney injury and metabolic alkalosis |
| url | http://dx.doi.org/10.1155/2022/1320259 |
| work_keys_str_mv | AT fatenaqeel hypercalcemiaacutekidneyinjuryandmetabolicalkalosis AT jenniferdelcastillo hypercalcemiaacutekidneyinjuryandmetabolicalkalosis AT bernardgjaar hypercalcemiaacutekidneyinjuryandmetabolicalkalosis AT mohamadhanouneh hypercalcemiaacutekidneyinjuryandmetabolicalkalosis |