Systemic immune-inflammation index in critically ill patients with renal failure: a retrospective cohort study from Medical Information Mart for Intensive Care IV (MIMIC-IV) database
Objectives Systemic immune-inflammation index (SII) is a biomarker of inflammatory conditions; however, no scoring system has been evaluated for predicting mortality in patients with renal failure in intensive care unit (ICU). This study aimed to determine associations between SII level and mortalit...
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BMJ Publishing Group
2025-06-01
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| Series: | BMJ Open |
| Online Access: | https://bmjopen.bmj.com/content/15/6/e094203.full |
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| author | Yu-Cheng Chang Chia-Ying Hsiao Min-I Su Ying-Hsiang Lee Po-Lin Lin Wei-Ru Chiou Pi-Yi Chang |
| author_facet | Yu-Cheng Chang Chia-Ying Hsiao Min-I Su Ying-Hsiang Lee Po-Lin Lin Wei-Ru Chiou Pi-Yi Chang |
| author_sort | Yu-Cheng Chang |
| collection | DOAJ |
| description | Objectives Systemic immune-inflammation index (SII) is a biomarker of inflammatory conditions; however, no scoring system has been evaluated for predicting mortality in patients with renal failure in intensive care unit (ICU). This study aimed to determine associations between SII level and mortality in patients with renal failure.Design Using the Medical Information Mart for Intensive Care IV (V.2.0) database (USA), this retrospective study included 837 patients who were admitted to ICU with end-stage renal disease (ESRD), between 2008 and 2019.Primary and secondary outcome measures Cox proportional-hazards models were used to evaluate correlations between SII and outcomes, expressing results as hazard ratios (HRs) with 95% confidence intervals (95% CIs). Regression analysis was used to determine associations between variables and SII.Results In total, 837 adult patients from a total of 76 943 patients admitted to ICU were included, comprising 59.60% males with mean age 62.27±14.9 years and mean BMI 28.36±7.43 Kg/m2. Using median SII (1628 X 109 /L) as cut-off value, high (≥ 1628X109 /L) SII was also associated with an increased risk of ICU mortality (HR 1.97 (95% CI 1.15 to 3.35), p=0.034), in-hospital mortality (HR 1.95 (95% CI 1.23 to 3.09), p=0.017) and total mortality (HR 1.30 (95% CI 1.07 to 1.58), p=0.024).Conclusions SII may predict mortality in critically ill patients admitted to ICU with ESRD. SII ≥ 1628×109 /L correlates significantly with increased ICU mortality, in-hospital mortality and total mortality. |
| format | Article |
| id | doaj-art-edb7a2f7ec294543be01eb5975b17b9d |
| institution | OA Journals |
| issn | 2044-6055 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | BMJ Open |
| spelling | doaj-art-edb7a2f7ec294543be01eb5975b17b9d2025-08-20T02:31:13ZengBMJ Publishing GroupBMJ Open2044-60552025-06-0115610.1136/bmjopen-2024-094203Systemic immune-inflammation index in critically ill patients with renal failure: a retrospective cohort study from Medical Information Mart for Intensive Care IV (MIMIC-IV) databaseYu-Cheng Chang0Chia-Ying Hsiao1Min-I Su2Ying-Hsiang Lee3Po-Lin Lin4Wei-Ru Chiou5Pi-Yi Chang6Department of Cardiology, Asia University Hospital, Taichung, TaiwanDepartment of Medicine, MacKay Medical College, New Taipei, TaiwanDivision of Cardiology, Department of Internal Medicine, Taitung MacKay Memorial Hospital, Taitung, TaiwanDepartment of Artificial Intelligence and Medical Application, MacKay Junior College of Medicine, Nursing, and Management, Taipei, TaiwanDivision of Cardiology, Department of Internal Medicine, Hsinchu MacKay Memorial Hospital, Hsinchu, TaiwanDivision of Cardiology, Department of Internal Medicine, Taitung MacKay Memorial Hospital, Taitung, TaiwanDepartment of Medical Imaging, Taichung Veterans General Hospital, Taichung, TaiwanObjectives Systemic immune-inflammation index (SII) is a biomarker of inflammatory conditions; however, no scoring system has been evaluated for predicting mortality in patients with renal failure in intensive care unit (ICU). This study aimed to determine associations between SII level and mortality in patients with renal failure.Design Using the Medical Information Mart for Intensive Care IV (V.2.0) database (USA), this retrospective study included 837 patients who were admitted to ICU with end-stage renal disease (ESRD), between 2008 and 2019.Primary and secondary outcome measures Cox proportional-hazards models were used to evaluate correlations between SII and outcomes, expressing results as hazard ratios (HRs) with 95% confidence intervals (95% CIs). Regression analysis was used to determine associations between variables and SII.Results In total, 837 adult patients from a total of 76 943 patients admitted to ICU were included, comprising 59.60% males with mean age 62.27±14.9 years and mean BMI 28.36±7.43 Kg/m2. Using median SII (1628 X 109 /L) as cut-off value, high (≥ 1628X109 /L) SII was also associated with an increased risk of ICU mortality (HR 1.97 (95% CI 1.15 to 3.35), p=0.034), in-hospital mortality (HR 1.95 (95% CI 1.23 to 3.09), p=0.017) and total mortality (HR 1.30 (95% CI 1.07 to 1.58), p=0.024).Conclusions SII may predict mortality in critically ill patients admitted to ICU with ESRD. SII ≥ 1628×109 /L correlates significantly with increased ICU mortality, in-hospital mortality and total mortality.https://bmjopen.bmj.com/content/15/6/e094203.full |
| spellingShingle | Yu-Cheng Chang Chia-Ying Hsiao Min-I Su Ying-Hsiang Lee Po-Lin Lin Wei-Ru Chiou Pi-Yi Chang Systemic immune-inflammation index in critically ill patients with renal failure: a retrospective cohort study from Medical Information Mart for Intensive Care IV (MIMIC-IV) database BMJ Open |
| title | Systemic immune-inflammation index in critically ill patients with renal failure: a retrospective cohort study from Medical Information Mart for Intensive Care IV (MIMIC-IV) database |
| title_full | Systemic immune-inflammation index in critically ill patients with renal failure: a retrospective cohort study from Medical Information Mart for Intensive Care IV (MIMIC-IV) database |
| title_fullStr | Systemic immune-inflammation index in critically ill patients with renal failure: a retrospective cohort study from Medical Information Mart for Intensive Care IV (MIMIC-IV) database |
| title_full_unstemmed | Systemic immune-inflammation index in critically ill patients with renal failure: a retrospective cohort study from Medical Information Mart for Intensive Care IV (MIMIC-IV) database |
| title_short | Systemic immune-inflammation index in critically ill patients with renal failure: a retrospective cohort study from Medical Information Mart for Intensive Care IV (MIMIC-IV) database |
| title_sort | systemic immune inflammation index in critically ill patients with renal failure a retrospective cohort study from medical information mart for intensive care iv mimic iv database |
| url | https://bmjopen.bmj.com/content/15/6/e094203.full |
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