Synthesis, characterization, In silico, and In vitro studies of CuS–ZnO nanocomposite using mushroom extract
The study aimed to evaluate the antimicrobial and cytotoxicity properties of CuS–ZnO nanocomposite via green synthesis method using mushroom extract as a reducing agent. These biological activities relationship of experimental data's were evaluated through the novel computational tool of In Sil...
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| Language: | English |
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Elsevier
2025-03-01
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| Series: | Hybrid Advances |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2773207X25000144 |
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| author | S. Anbazhagi A. Murugesan M. Paramanantham K. Chinnaiah Karthik Kannan Nadezhda Palko K. Gurushankar |
| author_facet | S. Anbazhagi A. Murugesan M. Paramanantham K. Chinnaiah Karthik Kannan Nadezhda Palko K. Gurushankar |
| author_sort | S. Anbazhagi |
| collection | DOAJ |
| description | The study aimed to evaluate the antimicrobial and cytotoxicity properties of CuS–ZnO nanocomposite via green synthesis method using mushroom extract as a reducing agent. These biological activities relationship of experimental data's were evaluated through the novel computational tool of In Silico approach. It is essential to identify thread of emerging diseases. The absorbance peak value of 251 nm in UV–Vis, and crystal planes (101), and (101) in XRD pattern was identified in the nanocomposite of CuS–ZnO. Metal oxide, metal sulfide and the reducing ability of biomolecules in the mushroom extract were analysed using FTIR spectroscopy. The spherical morphology was identified in SEM and HR-TEM analyses. Elemental composition in the EDAX analysis supported the resulted as a nanocomposite. The CuS–ZnO nanocomposite significantly exhibited antimicrobial activity against the pathogens of S. aureus (21 mm-zone of inhibition) and E.coli (25 mm-zone of inhibition). The cytotoxicity analysis shows a CuS–ZnO Nanoparticles have more cytotoxic effect in U87 cell lines. Clavilactone D could be more effective against fungal infections. Hence, this study explores the antimicrobial and Vitro studies green-synthesized CuS–ZnO nanocomposite and examined the responsible major biocompound for activity through the theoretical study. Hence, this work becomes potential for nanomedicine applications. |
| format | Article |
| id | doaj-art-edb2de619d5f4e32a4662998203d6e91 |
| institution | Kabale University |
| issn | 2773-207X |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Hybrid Advances |
| spelling | doaj-art-edb2de619d5f4e32a4662998203d6e912025-01-28T04:15:01ZengElsevierHybrid Advances2773-207X2025-03-018100390Synthesis, characterization, In silico, and In vitro studies of CuS–ZnO nanocomposite using mushroom extractS. Anbazhagi0A. Murugesan1M. Paramanantham2K. Chinnaiah3Karthik Kannan4Nadezhda Palko5K. Gurushankar6PG & Research Department of Chemistry, Government Arts College (Affiliated to Bharathidasan University), Ariyalur, Tamil Nadu, 621713, IndiaPG & Research Department of Chemistry, Government Arts College (Affiliated to Bharathidasan University), Ariyalur, Tamil Nadu, 621713, India; Corresponding author. PG & Research Department of Chemistry, Government Arts College (Affiliated to Bharathidasan University), Ariyalur, Tamil Nadu, 621713, IndiaDepartment of Chemistry, V.S.S Government Arts College, Pulankurichi, Tamil Nadu, 630405, IndiaDepartment of Physics, School of Advanced Sciences, Kalasalingam Academy of Research and Education (Deemed to be University), Krishnankoil, 626126, Tamil Nadu, IndiaDepartment of Mechanical Engineering, Advanced Institute of Manufacturing with High-Tech Innovations, National Chung Cheng University, Chia-Yi, 621301, TaiwanLaboratory of Computational Modelling Drugs, Higher Medical and Biological School, South Ural State University, Chelyabinsk, 454 080, RussiaDepartment of Physics, School of Advanced Sciences, Kalasalingam Academy of Research and Education (Deemed to be University), Krishnankoil, 626126, Tamil Nadu, India; Laboratory of Computational Modelling Drugs, Higher Medical and Biological School, South Ural State University, Chelyabinsk, 454 080, Russia; Corresponding author. Department of Physics, School of Advanced Sciences, Kalasalingam Academy of Research and Education (Deemed to be University), Krishnankoil, 626126, Tamil Nadu, India.The study aimed to evaluate the antimicrobial and cytotoxicity properties of CuS–ZnO nanocomposite via green synthesis method using mushroom extract as a reducing agent. These biological activities relationship of experimental data's were evaluated through the novel computational tool of In Silico approach. It is essential to identify thread of emerging diseases. The absorbance peak value of 251 nm in UV–Vis, and crystal planes (101), and (101) in XRD pattern was identified in the nanocomposite of CuS–ZnO. Metal oxide, metal sulfide and the reducing ability of biomolecules in the mushroom extract were analysed using FTIR spectroscopy. The spherical morphology was identified in SEM and HR-TEM analyses. Elemental composition in the EDAX analysis supported the resulted as a nanocomposite. The CuS–ZnO nanocomposite significantly exhibited antimicrobial activity against the pathogens of S. aureus (21 mm-zone of inhibition) and E.coli (25 mm-zone of inhibition). The cytotoxicity analysis shows a CuS–ZnO Nanoparticles have more cytotoxic effect in U87 cell lines. Clavilactone D could be more effective against fungal infections. Hence, this study explores the antimicrobial and Vitro studies green-synthesized CuS–ZnO nanocomposite and examined the responsible major biocompound for activity through the theoretical study. Hence, this work becomes potential for nanomedicine applications.http://www.sciencedirect.com/science/article/pii/S2773207X25000144CuS–ZnO nanocompositeGreen synthesisMushroom extractAntimicrobial activityCytotoxicityApoptosis assays |
| spellingShingle | S. Anbazhagi A. Murugesan M. Paramanantham K. Chinnaiah Karthik Kannan Nadezhda Palko K. Gurushankar Synthesis, characterization, In silico, and In vitro studies of CuS–ZnO nanocomposite using mushroom extract Hybrid Advances CuS–ZnO nanocomposite Green synthesis Mushroom extract Antimicrobial activity Cytotoxicity Apoptosis assays |
| title | Synthesis, characterization, In silico, and In vitro studies of CuS–ZnO nanocomposite using mushroom extract |
| title_full | Synthesis, characterization, In silico, and In vitro studies of CuS–ZnO nanocomposite using mushroom extract |
| title_fullStr | Synthesis, characterization, In silico, and In vitro studies of CuS–ZnO nanocomposite using mushroom extract |
| title_full_unstemmed | Synthesis, characterization, In silico, and In vitro studies of CuS–ZnO nanocomposite using mushroom extract |
| title_short | Synthesis, characterization, In silico, and In vitro studies of CuS–ZnO nanocomposite using mushroom extract |
| title_sort | synthesis characterization in silico and in vitro studies of cus zno nanocomposite using mushroom extract |
| topic | CuS–ZnO nanocomposite Green synthesis Mushroom extract Antimicrobial activity Cytotoxicity Apoptosis assays |
| url | http://www.sciencedirect.com/science/article/pii/S2773207X25000144 |
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