Role of transbronchial lung cryobiopsy in diagnosing pulmonary alveolar proteinosis—a five-case series
Abstract Pulmonary alveolar proteinosis (PAP) is a rare, diffuse lung disease marked by the accumulation of PAS-positive proteinaceous material within distal airspaces. Diagnostic procedures include bronchoalveolar lavage, transbronchial lung biopsy (TBLB), and surgical lung biopsy (SLB). Recently,...
Saved in:
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
SpringerOpen
2025-03-01
|
| Series: | The Egyptian Journal of Bronchology |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s43168-025-00377-3 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849761647673999360 |
|---|---|
| author | Vimal Raj Ramachandran Hsu-Yuan Chen Yu-Chu Kuo Wen-Chien Cheng Biing-Ru Wu Wei-Chih Liao Chia-Hung Chen Chih-Yen Tu |
| author_facet | Vimal Raj Ramachandran Hsu-Yuan Chen Yu-Chu Kuo Wen-Chien Cheng Biing-Ru Wu Wei-Chih Liao Chia-Hung Chen Chih-Yen Tu |
| author_sort | Vimal Raj Ramachandran |
| collection | DOAJ |
| description | Abstract Pulmonary alveolar proteinosis (PAP) is a rare, diffuse lung disease marked by the accumulation of PAS-positive proteinaceous material within distal airspaces. Diagnostic procedures include bronchoalveolar lavage, transbronchial lung biopsy (TBLB), and surgical lung biopsy (SLB). Recently, transbronchial lung cryobiopsy (TBLC) has emerged as a promising technique for diagnosing parenchymal lung diseases. This case series investigates the efficacy of TBLC in diagnosing PAP and compares it to traditional TBLB methods. |
| format | Article |
| id | doaj-art-edb0f7f092f945d892ce95664e80aea0 |
| institution | DOAJ |
| issn | 2314-8551 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | The Egyptian Journal of Bronchology |
| spelling | doaj-art-edb0f7f092f945d892ce95664e80aea02025-08-20T03:05:56ZengSpringerOpenThe Egyptian Journal of Bronchology2314-85512025-03-011911510.1186/s43168-025-00377-3Role of transbronchial lung cryobiopsy in diagnosing pulmonary alveolar proteinosis—a five-case seriesVimal Raj Ramachandran0Hsu-Yuan Chen1Yu-Chu Kuo2Wen-Chien Cheng3Biing-Ru Wu4Wei-Chih Liao5Chia-Hung Chen6Chih-Yen Tu7Department of Respiratory Medicine, Mahatma Gandhi Medical College and Research Institute, Sri Balaji Vidyapeeth (Deemed-to-Be University)Department of Internal Medicine, Division of Pulmonary and Critical Care Medicine, China Medical University HospitalDepartment of Internal Medicine, Division of Pulmonary and Critical Care Medicine, China Medical University HospitalDepartment of Internal Medicine, Division of Pulmonary and Critical Care Medicine, China Medical University HospitalDepartment of Internal Medicine, Division of Pulmonary and Critical Care Medicine, China Medical University HospitalDepartment of Internal Medicine, Division of Pulmonary and Critical Care Medicine, China Medical University HospitalDepartment of Internal Medicine, Division of Pulmonary and Critical Care Medicine, China Medical University HospitalDepartment of Internal Medicine, Division of Pulmonary and Critical Care Medicine, China Medical University HospitalAbstract Pulmonary alveolar proteinosis (PAP) is a rare, diffuse lung disease marked by the accumulation of PAS-positive proteinaceous material within distal airspaces. Diagnostic procedures include bronchoalveolar lavage, transbronchial lung biopsy (TBLB), and surgical lung biopsy (SLB). Recently, transbronchial lung cryobiopsy (TBLC) has emerged as a promising technique for diagnosing parenchymal lung diseases. This case series investigates the efficacy of TBLC in diagnosing PAP and compares it to traditional TBLB methods.https://doi.org/10.1186/s43168-025-00377-3Pulmonary alveolar proteinosisTransbronchial lung cryobiopsyDiffuse parenchymal lung disease |
| spellingShingle | Vimal Raj Ramachandran Hsu-Yuan Chen Yu-Chu Kuo Wen-Chien Cheng Biing-Ru Wu Wei-Chih Liao Chia-Hung Chen Chih-Yen Tu Role of transbronchial lung cryobiopsy in diagnosing pulmonary alveolar proteinosis—a five-case series The Egyptian Journal of Bronchology Pulmonary alveolar proteinosis Transbronchial lung cryobiopsy Diffuse parenchymal lung disease |
| title | Role of transbronchial lung cryobiopsy in diagnosing pulmonary alveolar proteinosis—a five-case series |
| title_full | Role of transbronchial lung cryobiopsy in diagnosing pulmonary alveolar proteinosis—a five-case series |
| title_fullStr | Role of transbronchial lung cryobiopsy in diagnosing pulmonary alveolar proteinosis—a five-case series |
| title_full_unstemmed | Role of transbronchial lung cryobiopsy in diagnosing pulmonary alveolar proteinosis—a five-case series |
| title_short | Role of transbronchial lung cryobiopsy in diagnosing pulmonary alveolar proteinosis—a five-case series |
| title_sort | role of transbronchial lung cryobiopsy in diagnosing pulmonary alveolar proteinosis a five case series |
| topic | Pulmonary alveolar proteinosis Transbronchial lung cryobiopsy Diffuse parenchymal lung disease |
| url | https://doi.org/10.1186/s43168-025-00377-3 |
| work_keys_str_mv | AT vimalrajramachandran roleoftransbronchiallungcryobiopsyindiagnosingpulmonaryalveolarproteinosisafivecaseseries AT hsuyuanchen roleoftransbronchiallungcryobiopsyindiagnosingpulmonaryalveolarproteinosisafivecaseseries AT yuchukuo roleoftransbronchiallungcryobiopsyindiagnosingpulmonaryalveolarproteinosisafivecaseseries AT wenchiencheng roleoftransbronchiallungcryobiopsyindiagnosingpulmonaryalveolarproteinosisafivecaseseries AT biingruwu roleoftransbronchiallungcryobiopsyindiagnosingpulmonaryalveolarproteinosisafivecaseseries AT weichihliao roleoftransbronchiallungcryobiopsyindiagnosingpulmonaryalveolarproteinosisafivecaseseries AT chiahungchen roleoftransbronchiallungcryobiopsyindiagnosingpulmonaryalveolarproteinosisafivecaseseries AT chihyentu roleoftransbronchiallungcryobiopsyindiagnosingpulmonaryalveolarproteinosisafivecaseseries |