Health-related quality of life after 12 months post discharge in patients hospitalised with COVID-19-related severe acute respiratory infection (SARI): a prospective analysis of SF-36 data and correlation with retrospective admission data on age, disease severity, and frailty
Objective To assess the impact of HRQoL in patients hospitalised with COVID-19-related SARI at 1 year post discharge, focusing on the potential impact of age, frailty, and disease severity.Method Routinely collected outcome data on 1207 patients admitted with confirmed COVID-19 related SARI across a...
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BMJ Publishing Group
2024-03-01
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| Series: | BMJ Open |
| Online Access: | https://bmjopen.bmj.com/content/14/3/e076797.full |
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| author | Jufen Zhang Gouri Koduri Gavin Wright Mohiuddin Khan Zakiuddin Mohammed Jiawei Huang Keerthi Senthil Amir Zadeh-Kochek Jonathan Heung-san Au Ravi Saripalli Omar Ghauri San Kim Carol Alves |
| author_facet | Jufen Zhang Gouri Koduri Gavin Wright Mohiuddin Khan Zakiuddin Mohammed Jiawei Huang Keerthi Senthil Amir Zadeh-Kochek Jonathan Heung-san Au Ravi Saripalli Omar Ghauri San Kim Carol Alves |
| author_sort | Jufen Zhang |
| collection | DOAJ |
| description | Objective To assess the impact of HRQoL in patients hospitalised with COVID-19-related SARI at 1 year post discharge, focusing on the potential impact of age, frailty, and disease severity.Method Routinely collected outcome data on 1207 patients admitted with confirmed COVID-19 related SARI across all three secondary care sites in our NHS trust over 3 months were assessed in this retrospective cohort study. Of those surviving 1 year, we prospectively collected 36-item short form (SF-36) HRQoL questionnaires, comparing three age groups (<49, 49–69, and the over 69-year-olds), the relative impact of frailty (using the Clinical Frailty Score; CFS), and disease severity (using National Early Warning Score; NEWS) on HRQoL domains.Results Overall mortality was 46.5% in admitted patients. In our SF-36 cohort (n=169), there was a significant reduction in all HRQoL domains versus normative data; the most significant reductions were in the physical component (p<0.001) across all ages and the emotional component (p<0.01) in the 49–69 year age group, with age having no additional impact on HRQoL. However, there was a significant correlation between physical well-being versus CFS (the correlation coefficient=−0.37, p<0.05), though not NEWS, with no gender difference observed.Conclusion There was a significant reduction in all SF-36 domains at 1 year. Poor CFS at admission was associated with a significant and prolonged impact on physical parameters at 1 year. Age had little impact on the severity of HRQoL, except in the domains of physical functioning and the overall physical component. |
| format | Article |
| id | doaj-art-edb0b9f0fc0f4c0e9ee112f59e596211 |
| institution | DOAJ |
| issn | 2044-6055 |
| language | English |
| publishDate | 2024-03-01 |
| publisher | BMJ Publishing Group |
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| series | BMJ Open |
| spelling | doaj-art-edb0b9f0fc0f4c0e9ee112f59e5962112025-08-20T03:12:39ZengBMJ Publishing GroupBMJ Open2044-60552024-03-0114310.1136/bmjopen-2023-076797Health-related quality of life after 12 months post discharge in patients hospitalised with COVID-19-related severe acute respiratory infection (SARI): a prospective analysis of SF-36 data and correlation with retrospective admission data on age, disease severity, and frailtyJufen Zhang0Gouri Koduri1Gavin Wright2Mohiuddin Khan3Zakiuddin Mohammed4Jiawei Huang5Keerthi Senthil6Amir Zadeh-Kochek7Jonathan Heung-san Au8Ravi Saripalli9Omar Ghauri10San Kim11Carol Alves12Anglia Ruskin University, Chelmsford, Essex, UKAnglia Ruskin University, Chelmsford, Essex, UKGastroenterology, Mid and South Essex NHS Foundation Trust, Essex, UKMedicine, Mid and South Essex NHS Foundation Trust, Essex, UKMedicine, Mid and South Essex NHS Foundation Trust, Essex, UKMedicine, Mid and South Essex NHS Foundation Trust, Essex, UKMedicine, Mid and South Essex NHS Foundation Trust, Essex, UKMedicine, Mid and South Essex NHS Foundation Trust, Essex, UKSouthend University Hospital, Mid and South Essex NHS Foundation Trust, Westcliff-on-Sea, UKMedicine, Mid and South Essex NHS Foundation Trust, Essex, UKMedicine, Mid and South Essex NHS Foundation Trust, Essex, UKMedicine, Mid and South Essex NHS Foundation Trust, Essex, UKResearch and Development, Mid and South Essex NHS Foundation Trust, Essex, UKObjective To assess the impact of HRQoL in patients hospitalised with COVID-19-related SARI at 1 year post discharge, focusing on the potential impact of age, frailty, and disease severity.Method Routinely collected outcome data on 1207 patients admitted with confirmed COVID-19 related SARI across all three secondary care sites in our NHS trust over 3 months were assessed in this retrospective cohort study. Of those surviving 1 year, we prospectively collected 36-item short form (SF-36) HRQoL questionnaires, comparing three age groups (<49, 49–69, and the over 69-year-olds), the relative impact of frailty (using the Clinical Frailty Score; CFS), and disease severity (using National Early Warning Score; NEWS) on HRQoL domains.Results Overall mortality was 46.5% in admitted patients. In our SF-36 cohort (n=169), there was a significant reduction in all HRQoL domains versus normative data; the most significant reductions were in the physical component (p<0.001) across all ages and the emotional component (p<0.01) in the 49–69 year age group, with age having no additional impact on HRQoL. However, there was a significant correlation between physical well-being versus CFS (the correlation coefficient=−0.37, p<0.05), though not NEWS, with no gender difference observed.Conclusion There was a significant reduction in all SF-36 domains at 1 year. Poor CFS at admission was associated with a significant and prolonged impact on physical parameters at 1 year. Age had little impact on the severity of HRQoL, except in the domains of physical functioning and the overall physical component.https://bmjopen.bmj.com/content/14/3/e076797.full |
| spellingShingle | Jufen Zhang Gouri Koduri Gavin Wright Mohiuddin Khan Zakiuddin Mohammed Jiawei Huang Keerthi Senthil Amir Zadeh-Kochek Jonathan Heung-san Au Ravi Saripalli Omar Ghauri San Kim Carol Alves Health-related quality of life after 12 months post discharge in patients hospitalised with COVID-19-related severe acute respiratory infection (SARI): a prospective analysis of SF-36 data and correlation with retrospective admission data on age, disease severity, and frailty BMJ Open |
| title | Health-related quality of life after 12 months post discharge in patients hospitalised with COVID-19-related severe acute respiratory infection (SARI): a prospective analysis of SF-36 data and correlation with retrospective admission data on age, disease severity, and frailty |
| title_full | Health-related quality of life after 12 months post discharge in patients hospitalised with COVID-19-related severe acute respiratory infection (SARI): a prospective analysis of SF-36 data and correlation with retrospective admission data on age, disease severity, and frailty |
| title_fullStr | Health-related quality of life after 12 months post discharge in patients hospitalised with COVID-19-related severe acute respiratory infection (SARI): a prospective analysis of SF-36 data and correlation with retrospective admission data on age, disease severity, and frailty |
| title_full_unstemmed | Health-related quality of life after 12 months post discharge in patients hospitalised with COVID-19-related severe acute respiratory infection (SARI): a prospective analysis of SF-36 data and correlation with retrospective admission data on age, disease severity, and frailty |
| title_short | Health-related quality of life after 12 months post discharge in patients hospitalised with COVID-19-related severe acute respiratory infection (SARI): a prospective analysis of SF-36 data and correlation with retrospective admission data on age, disease severity, and frailty |
| title_sort | health related quality of life after 12 months post discharge in patients hospitalised with covid 19 related severe acute respiratory infection sari a prospective analysis of sf 36 data and correlation with retrospective admission data on age disease severity and frailty |
| url | https://bmjopen.bmj.com/content/14/3/e076797.full |
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