The NF1 gene mutations and co-mutations in lung adenocarcinomas with brain metastasis

The NF1 gene mutations and co-mutations in lung adenocarcinomas with brain metastasis

Background: The co-occurrence of lung adenocarcinoma and brain metastasis remains a significant cause of morbidity and mortality despite advancements in cancer treatment. The activity of neurofibromin, the product of Neurofibromatosis Type 1 gene (NF1), is crucial in regulating the RAS/MAPK pathway....

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Main Authors: Nesibe Kahraman-Cetin, Dilara Akin, Seda Orenay-Boyacioglu, Olcay Boyacioglu, Ibrahim Halil Erdogdu, Esin Oktay, Ibrahim Meteoglu
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2025-04-01
Series:Indian Journal of Pathology and Microbiology
Subjects:
brain metastasis
comutation
lung adenocarcinoma
neurofibromatosis type 1
nf1 mutations
Online Access:https://journals.lww.com/10.4103/ijpm.ijpm_424_24
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https://journals.lww.com/10.4103/ijpm.ijpm_424_24

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