Elevated Serum Total Bilirubin Concentrations Are Negatively Associated with Diabetic Retinopathy among the Chinese Northeastern Population
Objective. To evaluate the association between serum total bilirubin concentration (STBC) and diabetic retinopathy (DR) among the Chinese northeastern population. Methods. A cross-sectional study was conducted in Liaoning between January 2015 and May 2017. Results. A total of 742 subjects (419 men a...
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | International Journal of Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2018/6539385 |
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| author | Dan Zhang Wei Zhang Shi Jin Wei Wang Dan Guo Lu Wang |
| author_facet | Dan Zhang Wei Zhang Shi Jin Wei Wang Dan Guo Lu Wang |
| author_sort | Dan Zhang |
| collection | DOAJ |
| description | Objective. To evaluate the association between serum total bilirubin concentration (STBC) and diabetic retinopathy (DR) among the Chinese northeastern population. Methods. A cross-sectional study was conducted in Liaoning between January 2015 and May 2017. Results. A total of 742 subjects (419 men and 323 women) with type 2 diabetes mellitus (DM) who visited an ophthalmic clinic were included in this study. The mean age of the subjects was 59.55 ± 10.63 years, and 43.5% of the subjects were women. The mean of DM duration was 11.01 ± 7.35 years. STBC were negatively correlated with DM duration, urea nitrogen, serum creatinine, uric acid, and urine microalbumin. After adjusting for confounding factors, as a continuous variable, STBC was inversely associated with the risk of DR in total subjects (OR: 0.95, 95% CI: 0.93–0.99). When STBC was used as a tertiary variable, compared with the first tertile, the OR in the third tertile was 0.37 (95% CI: 0.22–0.64) in total subjects. Conclusion. Our results demonstrate that a significant negative association was found between STBC and DR. STBC might be an early clinical marker for predicting the occurrence of DR. |
| format | Article |
| id | doaj-art-eda8c3833fcc490694fc93d5cda18e62 |
| institution | OA Journals |
| issn | 1687-8337 1687-8345 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Endocrinology |
| spelling | doaj-art-eda8c3833fcc490694fc93d5cda18e622025-08-20T02:21:39ZengWileyInternational Journal of Endocrinology1687-83371687-83452018-01-01201810.1155/2018/65393856539385Elevated Serum Total Bilirubin Concentrations Are Negatively Associated with Diabetic Retinopathy among the Chinese Northeastern PopulationDan Zhang0Wei Zhang1Shi Jin2Wei Wang3Dan Guo4Lu Wang5Department of Endocrinology, Fourth Hospital of China Medical University, Shenyang 110032, ChinaDepartment of Endocrinology, Fourth Hospital of China Medical University, Shenyang 110032, ChinaDepartment of Endocrinology, Fourth Hospital of China Medical University, Shenyang 110032, ChinaDepartment of Endocrinology, Fourth Hospital of China Medical University, Shenyang 110032, ChinaDepartment of Endocrinology, Fourth Hospital of China Medical University, Shenyang 110032, ChinaDepartment of Endocrinology, Fourth Hospital of China Medical University, Shenyang 110032, ChinaObjective. To evaluate the association between serum total bilirubin concentration (STBC) and diabetic retinopathy (DR) among the Chinese northeastern population. Methods. A cross-sectional study was conducted in Liaoning between January 2015 and May 2017. Results. A total of 742 subjects (419 men and 323 women) with type 2 diabetes mellitus (DM) who visited an ophthalmic clinic were included in this study. The mean age of the subjects was 59.55 ± 10.63 years, and 43.5% of the subjects were women. The mean of DM duration was 11.01 ± 7.35 years. STBC were negatively correlated with DM duration, urea nitrogen, serum creatinine, uric acid, and urine microalbumin. After adjusting for confounding factors, as a continuous variable, STBC was inversely associated with the risk of DR in total subjects (OR: 0.95, 95% CI: 0.93–0.99). When STBC was used as a tertiary variable, compared with the first tertile, the OR in the third tertile was 0.37 (95% CI: 0.22–0.64) in total subjects. Conclusion. Our results demonstrate that a significant negative association was found between STBC and DR. STBC might be an early clinical marker for predicting the occurrence of DR.http://dx.doi.org/10.1155/2018/6539385 |
| spellingShingle | Dan Zhang Wei Zhang Shi Jin Wei Wang Dan Guo Lu Wang Elevated Serum Total Bilirubin Concentrations Are Negatively Associated with Diabetic Retinopathy among the Chinese Northeastern Population International Journal of Endocrinology |
| title | Elevated Serum Total Bilirubin Concentrations Are Negatively Associated with Diabetic Retinopathy among the Chinese Northeastern Population |
| title_full | Elevated Serum Total Bilirubin Concentrations Are Negatively Associated with Diabetic Retinopathy among the Chinese Northeastern Population |
| title_fullStr | Elevated Serum Total Bilirubin Concentrations Are Negatively Associated with Diabetic Retinopathy among the Chinese Northeastern Population |
| title_full_unstemmed | Elevated Serum Total Bilirubin Concentrations Are Negatively Associated with Diabetic Retinopathy among the Chinese Northeastern Population |
| title_short | Elevated Serum Total Bilirubin Concentrations Are Negatively Associated with Diabetic Retinopathy among the Chinese Northeastern Population |
| title_sort | elevated serum total bilirubin concentrations are negatively associated with diabetic retinopathy among the chinese northeastern population |
| url | http://dx.doi.org/10.1155/2018/6539385 |
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