Encapsulation of hydrophobic bioactive compounds in yeast cells: mechanisms, challenges, and applications in biotechnology
Encapsulation of hydrophobic bioactive compounds represents a transformative approach in biotechnology for enhancing stability, bioavailability, and controlled release of these molecules. This review explores key aspects of hydrophobic bioactive compounds, including their types, properties, and appl...
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| Format: | Article |
| Language: | English |
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Stepan Gzhytskyi National University of Veterinary Medicine and Biotechnologies Lviv
2024-10-01
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| Series: | Науковий вісник Львівського національного університету ветеринарної медицини та біотехнологій імені С.З. Ґжицького. Серія: Харчові технології |
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| Online Access: | https://nvlvet.com.ua/index.php/food/article/view/5423 |
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| author | A. Sobolieva N. Shemedyuk V. Muzyka O. Rudenko Kh. Malysheva |
| author_facet | A. Sobolieva N. Shemedyuk V. Muzyka O. Rudenko Kh. Malysheva |
| author_sort | A. Sobolieva |
| collection | DOAJ |
| description | Encapsulation of hydrophobic bioactive compounds represents a transformative approach in biotechnology for enhancing stability, bioavailability, and controlled release of these molecules. This review explores key aspects of hydrophobic bioactive compounds, including their types, properties, and applications across diverse fields such as pharmaceuticals, nutraceuticals, and cosmetics. Challenges associated with the stability and bioavailability of hydrophobic compounds, driven by their susceptibility to environmental factors like light, oxygen, and temperature, are critically analyzed. The potential of yeast cells, particularly Saccharomyces cerevisiae, as biocompatible and biodegradable encapsulation platforms is discussed in detail. The robust cell wall structure, composed of β-glucans, mannans, and chitin, provides a natural barrier that protects encapsulated substances from degradation while enabling the gradual release of active ingredients. Advanced encapsulation techniques, such as the use of polysaccharide coatings, microgels, and nanoparticles, are evaluated for their ability to enhance encapsulation efficacy and delivery efficiency. Moreover, the application of biopolymers and auxiliary substances to improve the protective capabilities of encapsulated systems is explored. Finally, cutting-edge analytical methods, including spectrophotometry and high-performance liquid chromatography, are presented for assessing stability, bioavailability, and release profiles of encapsulated compounds. This review underscores the significant potential of yeast cell encapsulation in addressing challenges in biotechnology, offering innovative solutions for sustainable and effective delivery systems. |
| format | Article |
| id | doaj-art-eda7f8d3caec4643b242b53e08286afc |
| institution | DOAJ |
| issn | 2519-268X 2707-5885 |
| language | English |
| publishDate | 2024-10-01 |
| publisher | Stepan Gzhytskyi National University of Veterinary Medicine and Biotechnologies Lviv |
| record_format | Article |
| series | Науковий вісник Львівського національного університету ветеринарної медицини та біотехнологій імені С.З. Ґжицького. Серія: Харчові технології |
| spelling | doaj-art-eda7f8d3caec4643b242b53e08286afc2025-08-20T03:16:14ZengStepan Gzhytskyi National University of Veterinary Medicine and Biotechnologies LvivНауковий вісник Львівського національного університету ветеринарної медицини та біотехнологій імені С.З. Ґжицького. Серія: Харчові технології2519-268X2707-58852024-10-0126102808410.32718/nvlvet-f102125423Encapsulation of hydrophobic bioactive compounds in yeast cells: mechanisms, challenges, and applications in biotechnologyA. Sobolieva0N. Shemedyuk1V. Muzyka2O. Rudenko3Kh. Malysheva4Stepan Gzhytskyi National University of Veterinary Medicine and Biotechnologies Lviv, UkraineStepan Gzhytskyi National University of Veterinary Medicine and Biotechnologies Lviv, UkraineStepan Gzhytskyi National University of Veterinary Medicine and Biotechnologies Lviv, UkraineStepan Gzhytskyi National University of Veterinary Medicine and Biotechnologies Lviv, UkraineStepan Gzhytskyi National University of Veterinary Medicine and Biotechnologies Lviv, UkraineEncapsulation of hydrophobic bioactive compounds represents a transformative approach in biotechnology for enhancing stability, bioavailability, and controlled release of these molecules. This review explores key aspects of hydrophobic bioactive compounds, including their types, properties, and applications across diverse fields such as pharmaceuticals, nutraceuticals, and cosmetics. Challenges associated with the stability and bioavailability of hydrophobic compounds, driven by their susceptibility to environmental factors like light, oxygen, and temperature, are critically analyzed. The potential of yeast cells, particularly Saccharomyces cerevisiae, as biocompatible and biodegradable encapsulation platforms is discussed in detail. The robust cell wall structure, composed of β-glucans, mannans, and chitin, provides a natural barrier that protects encapsulated substances from degradation while enabling the gradual release of active ingredients. Advanced encapsulation techniques, such as the use of polysaccharide coatings, microgels, and nanoparticles, are evaluated for their ability to enhance encapsulation efficacy and delivery efficiency. Moreover, the application of biopolymers and auxiliary substances to improve the protective capabilities of encapsulated systems is explored. Finally, cutting-edge analytical methods, including spectrophotometry and high-performance liquid chromatography, are presented for assessing stability, bioavailability, and release profiles of encapsulated compounds. This review underscores the significant potential of yeast cell encapsulation in addressing challenges in biotechnology, offering innovative solutions for sustainable and effective delivery systems.https://nvlvet.com.ua/index.php/food/article/view/5423hydrophobic bioactive compounds, yeast cell encapsulation, saccharomyces cerevisiae, encapsulation methods, biotechnology applications |
| spellingShingle | A. Sobolieva N. Shemedyuk V. Muzyka O. Rudenko Kh. Malysheva Encapsulation of hydrophobic bioactive compounds in yeast cells: mechanisms, challenges, and applications in biotechnology Науковий вісник Львівського національного університету ветеринарної медицини та біотехнологій імені С.З. Ґжицького. Серія: Харчові технології hydrophobic bioactive compounds, yeast cell encapsulation, saccharomyces cerevisiae, encapsulation methods, biotechnology applications |
| title | Encapsulation of hydrophobic bioactive compounds in yeast cells: mechanisms, challenges, and applications in biotechnology |
| title_full | Encapsulation of hydrophobic bioactive compounds in yeast cells: mechanisms, challenges, and applications in biotechnology |
| title_fullStr | Encapsulation of hydrophobic bioactive compounds in yeast cells: mechanisms, challenges, and applications in biotechnology |
| title_full_unstemmed | Encapsulation of hydrophobic bioactive compounds in yeast cells: mechanisms, challenges, and applications in biotechnology |
| title_short | Encapsulation of hydrophobic bioactive compounds in yeast cells: mechanisms, challenges, and applications in biotechnology |
| title_sort | encapsulation of hydrophobic bioactive compounds in yeast cells mechanisms challenges and applications in biotechnology |
| topic | hydrophobic bioactive compounds, yeast cell encapsulation, saccharomyces cerevisiae, encapsulation methods, biotechnology applications |
| url | https://nvlvet.com.ua/index.php/food/article/view/5423 |
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