Organochlorine pesticides accumulation and breast cancer: A hospital-based case–control study
The aim of this study is to detect the accumulation status of organochlorine pesticides in breast cancer patients and to explore the relationship between organochlorine pesticides contamination and breast cancer development. We conducted a hospital-based case–control study in 56 patients with breast...
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| Language: | English |
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SAGE Publishing
2017-04-01
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| Series: | Tumor Biology |
| Online Access: | https://doi.org/10.1177/1010428317699114 |
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| author | Ting-Ting He An-Jun Zuo Ji-Gang Wang Peng Zhao |
| author_facet | Ting-Ting He An-Jun Zuo Ji-Gang Wang Peng Zhao |
| author_sort | Ting-Ting He |
| collection | DOAJ |
| description | The aim of this study is to detect the accumulation status of organochlorine pesticides in breast cancer patients and to explore the relationship between organochlorine pesticides contamination and breast cancer development. We conducted a hospital-based case–control study in 56 patients with breast cancer and 46 patients with benign breast disease. We detected the accumulation level of several organochlorine pesticides products (β-hexachlorocyclohexane, γ-hexachlorocyclohexane, polychlorinated biphenyls-28, polychlorinated biphenyls-52, pentachlorothioanisole, and pp′-dichlorodiphenyldichloroethane) in breast adipose tissues of all 102 patients using gas chromatography. Thereafter, we examined the expression status of estrogen receptor, progesterone receptor, human epidermal growth factor receptor-2 (HER2), and Ki-67 in 56 breast cancer cases by immunohistochemistry. In addition, we analyzed the risk of breast cancer in those patients with organochlorine pesticides contamination using a logistic regression model. Our data showed that breast cancer patients suffered high accumulation levels of pp′-dichlorodiphenyldichloroethane and polychlorinated biphenyls-52. However, the concentrations of pp′-dichlorodiphenyldichloroethane and polychlorinated biphenyls-52 were not related to clinicopathologic parameters of breast cancer. Further logistic regression analysis showed polychlorinated biphenyls-52 and pp′-dichlorodiphenyldichloroethane were risk factors for breast cancer. Our results provide new evidence on etiology of breast cancer. |
| format | Article |
| id | doaj-art-eda6b230c59b4f85a8a640f84c6cec83 |
| institution | DOAJ |
| issn | 1423-0380 |
| language | English |
| publishDate | 2017-04-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Tumor Biology |
| spelling | doaj-art-eda6b230c59b4f85a8a640f84c6cec832025-08-20T02:51:48ZengSAGE PublishingTumor Biology1423-03802017-04-013910.1177/1010428317699114Organochlorine pesticides accumulation and breast cancer: A hospital-based case–control studyTing-Ting He0An-Jun Zuo1Ji-Gang Wang2Peng Zhao3Department of Forensic Medicine, School of Basic Medicine, Qingdao University, Qingdao, ChinaDepartment of General Surgery, The Affiliated Hospital of Qingdao University, Qingdao, ChinaDepartment of Pathology, The Affiliated Hospital of Qingdao University, Qingdao, ChinaDepartment of Pathology, The Affiliated Hospital of Qingdao University, Qingdao, ChinaThe aim of this study is to detect the accumulation status of organochlorine pesticides in breast cancer patients and to explore the relationship between organochlorine pesticides contamination and breast cancer development. We conducted a hospital-based case–control study in 56 patients with breast cancer and 46 patients with benign breast disease. We detected the accumulation level of several organochlorine pesticides products (β-hexachlorocyclohexane, γ-hexachlorocyclohexane, polychlorinated biphenyls-28, polychlorinated biphenyls-52, pentachlorothioanisole, and pp′-dichlorodiphenyldichloroethane) in breast adipose tissues of all 102 patients using gas chromatography. Thereafter, we examined the expression status of estrogen receptor, progesterone receptor, human epidermal growth factor receptor-2 (HER2), and Ki-67 in 56 breast cancer cases by immunohistochemistry. In addition, we analyzed the risk of breast cancer in those patients with organochlorine pesticides contamination using a logistic regression model. Our data showed that breast cancer patients suffered high accumulation levels of pp′-dichlorodiphenyldichloroethane and polychlorinated biphenyls-52. However, the concentrations of pp′-dichlorodiphenyldichloroethane and polychlorinated biphenyls-52 were not related to clinicopathologic parameters of breast cancer. Further logistic regression analysis showed polychlorinated biphenyls-52 and pp′-dichlorodiphenyldichloroethane were risk factors for breast cancer. Our results provide new evidence on etiology of breast cancer.https://doi.org/10.1177/1010428317699114 |
| spellingShingle | Ting-Ting He An-Jun Zuo Ji-Gang Wang Peng Zhao Organochlorine pesticides accumulation and breast cancer: A hospital-based case–control study Tumor Biology |
| title | Organochlorine pesticides accumulation and breast cancer: A hospital-based case–control study |
| title_full | Organochlorine pesticides accumulation and breast cancer: A hospital-based case–control study |
| title_fullStr | Organochlorine pesticides accumulation and breast cancer: A hospital-based case–control study |
| title_full_unstemmed | Organochlorine pesticides accumulation and breast cancer: A hospital-based case–control study |
| title_short | Organochlorine pesticides accumulation and breast cancer: A hospital-based case–control study |
| title_sort | organochlorine pesticides accumulation and breast cancer a hospital based case control study |
| url | https://doi.org/10.1177/1010428317699114 |
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